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Cleveland Guardians vs Houston Astros Picks and Predictions April 22nd 2026
Houston heads into Progressive Field for Wednesday’s series finale trying to salvage a split after Tuesday’s 8-5 loss. The Astros are 9-16, last in the AL West, and just 2-10 on the road. Cleveland is 14-11, first in the AL Central, and 8-4 at home. First pitch is set for 1:10 p.m. ET, and the conditions look mild for an April afternoon in Cleveland, with temperatures around 60 degrees and only a light breeze. The game state matters here. Cleveland stole Tuesday’s win with a six-run eighth inning after trailing late, while Houston’s bullpen issues showed up again in a series where the Astros have already asked too much from the relief group. Even so, this is not a simple
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Kansas City Royals vs Baltimore Orioles Picks and Predictions April 22nd 2026
The Orioles and Royals wrap up their three-game set Wednesday afternoon at Kauffman Stadium, with first pitch scheduled for 2:10 p.m. ET. Baltimore comes in at 11-13, third in the AL East, while Kansas City is 8-16 and fifth in the AL Central. The series is tied 1-1 after the Royals stole Tuesday’s game 6-5 on a walk-off wild pitch, and that matters because both teams badly need a clean finish to the series after uneven starts. The recent form is not especially flattering for either side. The Orioles have lost six of their last eight and are 4-6 over their last 10, while the Royals just snapped an eight-game skid and are 2-8 over that same stretch. The weather
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Los Angeles Angels vs Toronto Blue Jays Picks and Predictions April 22nd 2026
The Blue Jays and Angels close out their series Wednesday afternoon at Angel Stadium, with first pitch set for 3:07 p.m. ET. Toronto comes in at 10-13, fourth in the AL East, and has a chance to finish a three-game sweep after taking the first two games 5-2 and 4-2. Los Angeles is 11-14, third in the AL West, and trying to stop a four-game slide. The stream is listed on MLB.TV, and the weather setup in Anaheim looks mild, with intervals of clouds and sun and temperatures in the low 70s. This is an interesting market because the Angels are still favored even though Toronto has won three straight overall and already handled this matchup twice in Anaheim. The
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Seattle Mariners vs Athletics Picks and Predictions April 22nd 2026
The Athletics head into Wednesday’s series finale at T-Mobile Park with a 13-11 record, first place in the AL West, and wins in the first two games of this set. Seattle is 10-15, fourth in the division, and trying to avoid a home sweep after dropping games by 6-4 and 5-2. First pitch is set for 4:10 p.m. ET, with the game listed on MLB.TV. This is a better spot than it might look at first glance for Oakland. The Athletics are 6-4 in their last 10 and 8-6 on the road, while Seattle is 4-6 in its last 10 even though it has played much better at home than away. The Mariners are 9-7 at T-Mobile Park, but their
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Detroit Tigers vs Milwaukee Brewers Picks and Predictions April 22nd 2026
The Brewers and Tigers meet Wednesday night at Comerica Park, with first pitch set for 6:40 p.m. ET in Detroit. Milwaukee comes in at 13-9, fourth in the NL Central, while Detroit is 12-12 and third in the AL Central. The Brewers snapped back with a 12-4 win in Tuesday’s opener, while the Tigers are trying to stop a two-game skid after what was easily one of their sloppier bullpen games of the young season. TV coverage is listed as Brewers.TV and Detroit SportsNet, and the current market has Detroit as a modest home favorite with a low total of 7.5. This is a pretty interesting spot because the records are close, but the game shape is a little different

Tennessee Volunteers vs South Carolina Gamecocks Picks and Predictions March 3rd 2026

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The Tennessee Volunteers head to Colonial Life Arena in Columbia, SC to face the South Carolina Gamecocks on Tuesday, March 3rd 2026 … more

George Mason Patriots vs VCU Rams Picks and Predictions – Tuesday, March 3, 2026

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George Mason Patriots vs VCU Rams Game Preview George Mason heads to Richmond for a Tuesday night Atlantic 10 matchup against VCU … more

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Dayton Flyers vs Richmond Spiders Picks and Predictions – Tuesday, March 3, 2026

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Dayton Flyers vs Richmond Spiders Game Preview Dayton heads to the Robins Center on Tuesday night for a 7:00 PM ET tip … more

Holy Cross Crusaders vs Lafayette Leopards Picks and Predictions – Tuesday, March 3, 2026

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Holy Cross Crusaders vs Lafayette Leopards Game Preview Holy Cross heads to Easton for a Tuesday night Patriot League matchup against Lafayette … more

Army Black Knights vs Bucknell Bison Picks and Predictions – Tuesday, March 3, 2026

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Army Black Knights vs Bucknell Bison Game Preview Army heads to Lewisburg for a Tuesday night Patriot League matchup against Bucknell at … more