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Cleveland Guardians vs Houston Astros Picks and Predictions April 22nd 2026
Houston heads into Progressive Field for Wednesday’s series finale trying to salvage a split after Tuesday’s 8-5 loss. The Astros are 9-16, last in the AL West, and just 2-10 on the road. Cleveland is 14-11, first in the AL Central, and 8-4 at home. First pitch is set for 1:10 p.m. ET, and the conditions look mild for an April afternoon in Cleveland, with temperatures around 60 degrees and only a light breeze. The game state matters here. Cleveland stole Tuesday’s win with a six-run eighth inning after trailing late, while Houston’s bullpen issues showed up again in a series where the Astros have already asked too much from the relief group. Even so, this is not a simple
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Kansas City Royals vs Baltimore Orioles Picks and Predictions April 22nd 2026
The Orioles and Royals wrap up their three-game set Wednesday afternoon at Kauffman Stadium, with first pitch scheduled for 2:10 p.m. ET. Baltimore comes in at 11-13, third in the AL East, while Kansas City is 8-16 and fifth in the AL Central. The series is tied 1-1 after the Royals stole Tuesday’s game 6-5 on a walk-off wild pitch, and that matters because both teams badly need a clean finish to the series after uneven starts. The recent form is not especially flattering for either side. The Orioles have lost six of their last eight and are 4-6 over their last 10, while the Royals just snapped an eight-game skid and are 2-8 over that same stretch. The weather
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Los Angeles Angels vs Toronto Blue Jays Picks and Predictions April 22nd 2026
The Blue Jays and Angels close out their series Wednesday afternoon at Angel Stadium, with first pitch set for 3:07 p.m. ET. Toronto comes in at 10-13, fourth in the AL East, and has a chance to finish a three-game sweep after taking the first two games 5-2 and 4-2. Los Angeles is 11-14, third in the AL West, and trying to stop a four-game slide. The stream is listed on MLB.TV, and the weather setup in Anaheim looks mild, with intervals of clouds and sun and temperatures in the low 70s. This is an interesting market because the Angels are still favored even though Toronto has won three straight overall and already handled this matchup twice in Anaheim. The
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Seattle Mariners vs Athletics Picks and Predictions April 22nd 2026
The Athletics head into Wednesday’s series finale at T-Mobile Park with a 13-11 record, first place in the AL West, and wins in the first two games of this set. Seattle is 10-15, fourth in the division, and trying to avoid a home sweep after dropping games by 6-4 and 5-2. First pitch is set for 4:10 p.m. ET, with the game listed on MLB.TV. This is a better spot than it might look at first glance for Oakland. The Athletics are 6-4 in their last 10 and 8-6 on the road, while Seattle is 4-6 in its last 10 even though it has played much better at home than away. The Mariners are 9-7 at T-Mobile Park, but their
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Detroit Tigers vs Milwaukee Brewers Picks and Predictions April 22nd 2026
The Brewers and Tigers meet Wednesday night at Comerica Park, with first pitch set for 6:40 p.m. ET in Detroit. Milwaukee comes in at 13-9, fourth in the NL Central, while Detroit is 12-12 and third in the AL Central. The Brewers snapped back with a 12-4 win in Tuesday’s opener, while the Tigers are trying to stop a two-game skid after what was easily one of their sloppier bullpen games of the young season. TV coverage is listed as Brewers.TV and Detroit SportsNet, and the current market has Detroit as a modest home favorite with a low total of 7.5. This is a pretty interesting spot because the records are close, but the game shape is a little different

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Purdue Boilermakers vs. Ohio State Buckeyes Pick & Prediction OCTOBER 10th 2023

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Ohio State wants its third trip to the state of Indiana this season to be as successful as the first two when … more

Duke Blue Devils quarterback runs with the football against NC State Wolfpack defense during NCAA game on October 10, 2023.

Duke Blue Devils vs. NC State Wolfpack Pick & Prediction OCTOBER 10th 2023

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The quarterback topic is running hot when it comes to Saturday night’s Atlantic Coast Conference game between visiting North Carolina State and … more

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Pittsburgh Panthers vs. Louisville Cardinals Pick & Prediction OCTOBER 10th 2023

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Minutes after Louisville finished a 33-20 upset of then-No. 10 Notre Dame last weekend, first-year Cardinals coach Jeff Brohm sounded a warning. … more

A football player in an Arkansas Razorbacks red jersey pressures the opposing quarterback as the ball is released.

Notre Dame Fighting Irish vs. Southern California Trojans Pick & Prediction OCTOBER 10th 2023

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Although Notre Dame has played seven consecutive weeks, coach Marcus Freeman insists his team isn’t tired. It’s starting to look that way, … more

Virginia Tech Hokies vs. Wake Forest Demon Deacons Pick & Prediction OCTOBER 10th 2023

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Wake Forest and Virginia Tech have piled up problems over the past few weeks that need addressing. But both teams also are … more