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The St. Louis Cardinals visit the San Francisco Giants at Oracle Park on Monday, September 22, 2025, in a critical series opener. Both clubs are hanging on to slim NL wild‑card hopes; a win here could swing momentum. Probable starters: Michael McGreevy (Cardinals) vs. Justin Verlander (Giants). Opening Odds: Giants ML ~ –150 | Cardinals ML ~ +125 | Over/Under around 8.0 runs Pick: Giants MoneylineProjected Final Score: Giants 5, Cardinals 3Total Lean: Over 8.0 The Giants are slightly more likely to pull this out, given home field, Verlander’s better recent performance, and the Cardinals’ inconsistent offense without Arenado. Expect the Giants to jump on St. Louis early and take advantage of any slippage in the bullpen. Also lean toward

The San Diego Padres return home to PETCO Park on Monday, September 22, 2025, as they open a three‑game series against the Milwaukee Brewers. The big news: veteran shortstop Xander Bogaerts is expected to return from a fractured left foot. San Diego (85‑71) is edging toward a postseason berth, while Milwaukee (95‑61) already clinched the NL Central and is jockeying for home‑field advantage. Opening Odds: Padres ML −128 | Brewers ML +109 | Total (O/U) 7.0 Pick: Padres MoneylineProjected Final Score: Padres 5, Brewers 3Total Lean: Over 7.0 San Diego gets a major boost with Bogaerts back, and Peralta—while excellent—faces a lineup now more complete and motivated. The Padres need this stretch run, and home field off a return could

The Washington Nationals visit the Atlanta Braves at Truist Park on Monday, September 22, 2025, as Atlanta looks for its ninth straight victory. The Braves (73‑83) have been eliminated from playoff contention for the first time since 2017 but are finishing strong, while the Nationals (64‑92) are aiming to avoid a last-place NL East finish. Opening Odds: Braves ML -247 | Nationals ML +205 | Runline ATL -1.5 (-109) | Total 7.0 (O -109 / U -111) Atlanta recently swept Detroit to close their final road trip, while Washington took two of three from the Mets. The Braves also swept the Nationals last week in a four-game set. For more on how these teams have fared lately, check the full

The New York Yankees continue their postseason push when they wrap up a four-game series against the Baltimore Orioles on Sunday at Camden Yards. New York (87-68) is riding momentum after a 6-1 win on Saturday, powered by home runs from Aaron Judge and Giancarlo Stanton, who reached his 450th career long ball. The Yankees remain just two games behind Toronto in the AL East with a little over a week left in the season. Baltimore (73-82) has been inconsistent, alternating wins and losses over their last six games. While they’ve been eliminated from postseason contention, the Orioles can play spoiler while evaluating young talent like Coby Mayo, who had two hits and drove in the lone run on Saturday.