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The Tennessee Titans are set to open the 2025 season on the road against the Denver Broncos, ushering in the Cam Ward era. Selected with the No. 1 overall pick, Ward is expected to bring hope to a franchise coming off a 3-14 campaign. Head coach Brian Callahan has emphasized patience, saying the Titans need Ward to simply play good football and rely on his teammates rather than shoulder the entire burden. Ward completed 10 of 19 passes for 145 yards during preseason action, highlighted by a 13-play touchdown drive in the team’s win over Minnesota on Aug. 22. With Will Levis sidelined for the season due to a lingering shoulder injury, Ward takes the reins with veterans Brandon Allen

The Seattle Seahawks are known for their hostile home-field environment, but that advantage faded last season. Seattle went just 3-6 at Lumen Field, losing six of its final seven home games, and missed the playoffs by one game in Mike Macdonald’s first year as head coach. Veteran defensive lineman Jarran Reed emphasized the importance of defending their turf: “We have to win at home — point blank, period. This is our sanctuary, this is where we play, and we have to use that to our advantage.” The Seahawks begin their 2025 campaign Sunday against NFC West rival San Francisco. Fans can find full breakdowns of upcoming matchups in the latest NFL previews The Seahawks overhauled their offense in the offseason.

The Houston Texans enter 2025 with one clear priority: keep quarterback C.J. Stroud upright. After a second season marred by heavy pressure and inconsistent line play, Houston spent the offseason revamping its offensive front. The test of whether those changes worked arrives immediately when the Texans travel west to face the Los Angeles Rams in Week 1. For more early matchups and analysis, check the full slate of NFL previews Only right tackle Tytus Howard returns as a starter from last year’s offensive line. Four new pieces will step in, including rookie left tackle Aireontae Ersery, who replaces longtime anchor Laremy Tunsil after his move to Washington. The pressure is immense on Ersery to protect Stroud’s blindside and help stabilize

The NFC North opener on Sunday between the Green Bay Packers and defending division champion Detroit Lions is filled with intrigue, highlighted by the potential debut of star edge rusher Micah Parsons in a Packers uniform. Parsons was acquired in a blockbuster trade with the Dallas Cowboys but has been managing a back injury in the days leading up to kickoff. Fans and bettors alike are watching closely as both teams enter the season with lofty expectations. For more breakdowns on the Week 1 slate, check out the full NFL previews Green Bay paid a steep price for Parsons, giving up two first-round picks and defensive lineman Kenny Clark. Now the question is whether their new defensive centerpiece will be