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The Friday night ACC spotlight shines on two programs heading in different directions as the Louisville Cardinals host the Clemson Tigers in a matchup that once carried College Football Playoff potential. Louisville enters at 7-2 after a stunning overtime loss to Cal — the Cardinals’ second home OT defeat in a month — while Clemson arrives at 4-5 trying to salvage bowl hopes and avoid a second straight losing season. Louisville’s defense has been one of the ACC’s most reliable units, ranking inside the national top 15 in total defense, but it allowed a season-worst 427 yards to Cal. Clemson’s Cade Klubnik presents a significant challenge, and the Tigers’ defense remains one of the league’s most athletic despite inconsistent results.

The Kentucky Wildcats (2-1) host the Eastern Illinois Panthers (1-2) on Friday, November 14 at 7:00 PM ET in Lexington, Ky. This follows Kentucky’s disappointing 96-88 loss to Louisville, as coach Mark Pope admitted his team fell below its standard. The Panthers meanwhile lost 78-58 at Notre Dame and remain under-the-radar. You can read more in our full NCAA Odds The opening spread and total have not been broadly posted, but Kentucky is expected to be a heavy favourite based on projected power ratings and early offshore openers.Current trends: Kentucky outlook: After a loss exposing defensive flaws and turnover issues, Kentucky needs to set the tone. Denzel Aberdeen leads the Wildcats at 16.0 PPG and 3.7 APG. Kentucky should control

The College Football Playoff picture tightens as the Indiana Hoosiers return home for the final time this season, hosting a struggling but rejuvenated Wisconsin Badgers squad on Saturday. Indiana enters unbeaten at 10-0 with a firm grip on a top-two CFP ranking, while Wisconsin arrives at 3-6 but fresh off its first conference win in more than a year. Indiana survived its closest call of the season last week, edging Penn State 27-24 thanks to a spectacular late touchdown. The Hoosiers remain on track to meet Ohio State for the Big Ten championship and a first-round CFP bye. But coach Curt Cignetti emphasized that the target on Indiana grows each week, and the team must handle every opponent’s best shot.

Duke brings a versatile, efficient attack into Friday’s home meeting with Indiana State. The Blue Devils handled Army 114-59 in West Point, a sharp two-way effort on a night celebrating Mike Krzyzewski. Duke is 3-0 and continues to flash elite defensive numbers. Freshman Cameron Boozer leads the team in scoring and rebounding. Dame Sarr broke out with 19 points and three steals. Duke has held all three opponents to 60 or fewer. You can review recent team form on the Duke team page from the NCAAB previews hub Indiana State enters 2-1 with a deep rotation. Ian Scott has opened strong with a double-double average. Interim coach Mark Slessinger continues to guide the Sycamores while Matthew Graves recovers from heart