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The Mets head to Busch Stadium on Monday night with a 2-1 record after dropping the series finale in Pittsburgh, while the Cardinals also sit at 2-1 after losing 11-7 to Tampa Bay on Sunday. First pitch is set for 7:45 p.m. local time in St. Louis, and the probable starters are Clay Holmes for New York and Kyle Leahy for St. Louis. The market has the Mets as a moderate road favorite, with the total mostly sitting between 8.5 and 9.0. This is an interesting early-season matchup because both teams have shown enough offense to matter, but they have gotten there in different ways. New York has looked steadier overall, with a more balanced profile through the first series,

Boston heads to Houston on Monday night trying to stop a two-game skid after dropping the final two games in Cincinnati. The Red Sox are 1-2 and still looking for some lineup stability without Triston Casas, while the Astros come in 2-2 after taking the final two games of their opening series against the Angels. First pitch is set for 8:10 p.m. ET at Daikin Park, with Ranger Suárez making his Boston debut against Lance McCullers Jr. in his first regular-season start since 2021. This is a pretty interesting early spot because both teams have clear strengths and obvious risk points. Boston’s pitching has looked sharper than Houston’s through the first few games, but the Astros have the more dangerous

The Yankees head into Seattle on Monday night at 3-0 after sweeping the Giants and allowing almost nothing on the mound in that opening series. New York has looked sharp early, especially from a pitching standpoint, and now gets its first real road test at T-Mobile Park against a Mariners club that split its first four games and just handled Cleveland 8-0 on Sunday. First pitch is set for 9:40 p.m. ET, with Ryan Weathers making his Yankees debut against Luis Castillo. This is a pretty interesting early-season matchup because both teams can make a case through pitching. The Yankees have opened the year with dominant run prevention, while Seattle has already shown enough swing-and-miss stuff to make life difficult

San Francisco heads into Petco Park on Monday night still searching for its first win after an ugly opening sweep against the Yankees. The Giants scored only one run in three games and now open an NL West series against a Padres club that went 1-2 against Detroit but at least showed some life on the mound. First pitch is set for 6:40 p.m. local time in San Diego, with Landen Roupp lined up against Walker Buehler in his Padres debut. This matchup matters early because both teams already feel some pressure, just in different ways. The Giants need offense, badly, while the Padres are trying to prove their rotation can hold together behind Dylan Cease’s departure and injuries elsewhere