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Detroit and Arizona close out this early interleague set on Wednesday afternoon at Chase Field, with first pitch scheduled for 3:40 p.m. ET. The Tigers are 2-3 after dropping a 7-5 game on Tuesday night, while the Diamondbacks have climbed to 2-3 and are trying to salvage some momentum after a slow start. Tarik Skubal gets the ball for Detroit against Zac Gallen for Arizona, and that pitching matchup is the main reason the Tigers opened as a fairly clear road favorite. This is one of those afternoon spots where the market really is asking a simple question: do you trust Skubal to be the best arm on the field by enough margin to outweigh Arizona’s home edge? I think

The Yankees head into Seattle for a late-afternoon matchup at T-Mobile Park on Wednesday, trying to bounce back after a 2-1 loss in the last meeting. New York is 3-1 and sitting second in the AL East, while Seattle is 3-2 and third in the AL West after putting together two straight wins. This game has the look of another tight one, maybe frustratingly tight, with two starters in strong early form and weather that should help the pitchers a bit more than the hitters. Cam Schlittler gets the ball for New York after a sharp first outing, and George Kirby counters for Seattle with his usual steady profile. Add in a very cold forecast with light rain and this

San Francisco and San Diego wrap up an early NL West set on Wednesday afternoon at PETCO Park, and neither club has looked especially comfortable out of the gate. Both teams are 1-3, both need some traction, and both have already played a tight game in this series after the Giants edged the Padres 3-2 on March 30. That probably matters a little. These teams are not far apart right now, even if the market is shading toward San Diego at home. The Giants come in off a win, which at least gives them a cleaner frame of mind after a rough first few games. The Padres are trying to respond after letting a close one slip away, and that

Minnesota heads to Kauffman Stadium on Wednesday night trying to stop an early skid, while Kansas City looks to keep a little momentum going after back-to-back wins. The Twins are just 1-3 through four games, and the offense has felt a bit choppy so far. The Royals are 2-2, not exactly rolling, but they have already shown they can win the kind of lower-scoring games this matchup may turn into. This one has a first-pitch feel of a grind rather than a shootout, especially with Joe Ryan on the mound for Minnesota and Noah Cameron making his season debut for Kansas City. The weather matters at least a little here. Light rain and a cool breeze at Kauffman could knock