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D.C. United host Orlando City at Audi Field on Saturday, April 25, with kickoff set for 7:30 PM ET in MLS regular-season play. The home side enter Matchday 10 at 2-4-3 with nine points, while Orlando arrive at 2-6-1 with seven points. That puts D.C. around the edge of the East playoff pack and leaves Orlando a little further back, so this is not just another early-season fixture. Both teams need it, though probably for different reasons. D.C. are trying to turn wild performances into actual wins, while Orlando are trying to prove that Wednesday’s bounce-back result was more than a one-night spike. The recent results make this one pretty interesting. D.C. just played out that chaotic 4-4 draw with

Saturday night at ScottsMiracle-Gro Field feels bigger than a normal April MLS match. Columbus are home at 7:30 p.m. ET and sit eighth in the Eastern Conference at 2-4-3, while Philadelphia arrive at 1-6-2 and 13th in the East, still trying to dig out from a rough opening stretch. The Union just came off that chaotic 3-3 draw in Toronto, and Columbus are coming in after a 2-1 win over the LA Galaxy, so both sides have at least some short-term momentum even if neither profile is especially stable right now. There is a little more pressure on Philadelphia because the record still looks ugly, even with five points from the last three matches. Columbus, meanwhile, have been better at

New York Red Bulls head to TQL Stadium on Saturday, April 25, for an MLS regular-season match with kickoff set for 7:30 PM ET. This is an Eastern Conference game with real urgency on both sides. The Red Bulls come in at 3-3-3 with 12 points, while FC Cincinnati sits at 2-4-3 with 9 points, and the standings are tight enough that one result can shift the mood quickly. New York is sitting above Cincinnati in the East right now, but neither side has looked especially comfortable over the last couple of weeks. The recent form is noisy, and honestly that is part of what makes this match interesting from a betting angle. Cincinnati just finished a wild three-match week

Houston Dynamo and Austin FC meet Saturday, April 25, 2026, at Q2 Stadium in Austin, with kickoff set for 8:30 PM ET in MLS play. It is a Texas matchup with both teams still trying to find real consistency in the Western Conference, but Houston enters in the better table spot while Austin is trying to stop another rough stretch from getting worse. Austin comes into this one near the bottom of the West after a heavy 5-1 road loss to San Jose. The attack has not been completely dead, which matters for bettors, but the defensive numbers are hard to ignore. Austin has been leaking chances, conceding in volume, and asking Brad Stuver to do a lot of work.