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Santos travel to Buenos Aires to face San Lorenzo on Tuesday, April 28, 2026, at Estadio Pedro Bidegain in Copa Sudamericana Group D. Kickoff is set for 5:50 PM ET, and this is already an important group-stage spot because the table has created very different pressure for both clubs. San Lorenzo sits at the top of Group D with four points through two matches, while Santos is still looking for its first win after taking one point from its first two games. That changes the psychology here. San Lorenzo can control risk at home and still feel good about its position. Santos probably needs something more aggressive, even if a road draw would not be a disaster. The betting market

Sao Paulo head to Bogotá to face Millonarios at Estadio Nemesio Camacho El Campín in Copa Sudamericana Group C, with kickoff set for Tuesday, April 28 at 8:30 PM ET. This is one of the more interesting group-stage spots on the board because Sao Paulo are top of the group with a perfect start, while Millonarios are trying to close the gap at home. Sao Paulo have taken six points from their first two group matches and have not conceded yet in the competition. Millonarios sit third with three points, so there is real pressure on the Colombian side to get something from this match. A home win would pull them right back into the race. A loss would make

Audax Italiano travel to face Barracas Central in CONMEBOL Sudamericana Group G action on Tuesday, April 28, 2026, with kickoff set for 8:00 PM ET at Estadio Florencio Solá in Buenos Aires. This is Matchday 3 of the group stage, and the table makes the spot pretty clear: Barracas are still looking for their first win after two draws, while Audax sit just ahead of them with three points. The group is tight enough that neither side can treat this casually. Olimpia lead the section, Audax are in second, Barracas are third, and Vasco da Gama are sitting bottom after two matches. That puts extra pressure on Barracas at home, because another draw would keep them alive but still leave

Deportivo Recoleta host Dep. Cuenca in Copa Sudamericana Group D on Wednesday, April 29, 2026, at Estadio Ueno Defensores del Chaco in Asuncion. Kickoff is set for 00:30 UTC, which makes this a late Tuesday night spot for bettors following the South American board. The group is tight through the opening two matches. Dep. Cuenca enter second with three points, while Deportivo Recoleta sit third with two points after draws against Santos and San Lorenzo. That makes this a fairly important swing match. A Recoleta win flips the table pressure. A Cuenca result keeps them in a stronger qualification position and puts more stress on the chasing pack. Recoleta have been competitive, but they still need their first group win.