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San Diego opens this series at PNC Park on Monday night, with first pitch set for 6:40 p.m. ET in Pittsburgh. The Padres come in 4-5 and third in the NL West after winning back-to-back games in Boston, while the Pirates are 6-3, third in the NL Central, and riding a five-game winning streak after sweeping Baltimore. Regional coverage is on SportsNet PT, with streaming also available via MLB.TV. The weather looks cold for early April, around 42 degrees at game time with a light breeze and little rain risk, which matters in a park that can already play a bit bigger at night. The pitching matchup is German Marquez against Bubba Chandler, and that is really where this handicap

Cincinnati opens a four-game set at loanDepot Park on Monday night, with first pitch scheduled for 6:40 p.m. ET in Miami. Both clubs are 6-3, but they got there differently. The Reds just swept Texas on the road and allowed only four runs all weekend, while the Marlins had to survive a long rain delay and a late comeback to avoid a sweep against the Yankees on Sunday. Miami is 5-1 at home, Cincinnati is 3-0 on the road, and this feels like one of the tighter games on the board. There is also a little more context here than the surface records show. The Reds made the playoffs last season and have started this year by leaning on run

Milwaukee opens a three-game set at Fenway Park on Monday night, with first pitch scheduled for 6:45 p.m. ET in Boston. The Brewers come in at 7-2, 2-1 on the road, and sitting on top of the NL Central. Boston is 2-7, 1-2 at home, and trying to stop another slide after dropping two straight to San Diego. The game is on NESN and Brewers.TV, and the weather looks chilly even by early-April standards, with game-time temperatures in the mid to upper 40s and a noticeable breeze. This is a pretty clean handicap on paper. Milwaukee has been the better offense, the steadier pitching staff, and the better overall team through the first nine games. The Brewers just took a

St. Louis opens a three-game set at Nationals Park on Monday night, with first pitch scheduled for 6:45 p.m. ET in Washington. The Cardinals come in 5-4 and fourth in the NL Central after salvaging the finale in Detroit, while the Nationals are 3-6, fifth in the NL East, and trying to stop a five-game slide after getting swept by the Dodgers. MLB.TV has the stream, and the weather looks playable with temperatures around the low 60s at first pitch, very little rain risk, and a light breeze around 10 mph. Andre Pallante gets the ball for St. Louis against Zack Littell for Washington. Pallante’s line is clean after his first outing, 1-0 with a 0.00 ERA, while Littell enters