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Washington heads to Milwaukee for Friday’s opener of this three-game set at 4-8, while the Brewers sit at 8-4 and tied for first in the NL Central. First pitch is scheduled for 7:40 p.m. ET at American Family Field. The Nationals have dropped seven of their last eight, including the final two games of their series against St. Louis, while Milwaukee is trying to rebound after Boston took the last two games of its midweek set. The listed pitching matchup is Jake Irvin for Washington against Chad Patrick for Milwaukee, and that is the biggest reason the Brewers opened as a clear home favorite. Patrick enters at 1-0 with a 0.96 ERA, while Irvin has been hit hard early and

B oston heads to Busch Stadium on Friday night trying to build on back-to-back wins after a rough 4-8 start, while St. Louis comes in at 7-5 and has also won two straight. First pitch is set for 8:15 p.m. ET in St. Louis. The Red Sox are still trying to climb out of the bottom of the AL East, and the Cardinals have been better overall, especially at home, where they are 4-2 so far. This one is interesting because the market is making Boston the road favorite, and that usually says more about the pitching matchup than the teams’ records. The probable starters are Connelly Early for Boston and Dustin May for St. Louis. Early enters with a

Colorado and San Diego open this NL West matchup Friday night at PETCO Park with both clubs sitting at 6-6, which feels about right for two teams that have flashed upside without really settling in yet. First pitch is set for 9:40 p.m. ET in San Diego. The Rockies come in on a four-game winning streak after a strong showing in Houston, while the Padres return home after finishing a 4-2 road trip and snapping back to .500. The market still leans clearly toward San Diego despite the even records, and that is mostly about the setting, the lineup floor, and some skepticism around whether Colorado’s recent run travels. The listed pitching matchup is Tomoyuki Sugano for Colorado against Walker

Houston heads to Seattle for the opener of this four-game AL West series with a 6-7 record and a four-game skid, while the Mariners are 4-9 and have dropped five straight. First pitch is set for 9:40 p.m. ET on Friday, April 10, at T-Mobile Park. On paper, this looks like a matchup between two struggling lineups or, maybe more accurately, one lineup that has been cold and another team that is just trying to survive a rough stretch of injuries. Seattle is still getting excellent pitching, but the offense has been one of the weakest in baseball through the first two weeks. The pitching matchup is Tatsuya Imai for Houston against Emerson Hancock for Seattle. That matters because Hancock