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The Seattle Mariners visit the Minnesota Twins on Wednesday, April 29, 2026, at Target Field in Minneapolis, MN. First pitch is set for 1:40 PM ET, with Seattle entering at 15-16 and Minnesota sitting at 13-17 after splitting the first two games of this series. The Mariners have won seven of their last 10 and come in off a clean 7-1 win on Tuesday, while the Twins have dropped eight of their last 10 and are trying to steady themselves before this slide gets heavier. Seattle is a short road favorite at -130, Minnesota is +109 at home, and the total is sitting at 8.0 with clear skies and a light breeze expected. This is a pretty interesting day-game handicap

The Los Angeles Angels and Chicago White Sox wrap up their series Wednesday afternoon at Rate Field in Chicago. First pitch is set for 1:10 PM ET, with the game airing on CHSN, and this is another spot on the daily MLB previews board where the price is more interesting than the records. Los Angeles enters at 12-19, fourth in the AL West, and the Angels are in a bad stretch. They have lost five straight and nine of their last ten. Chicago is 13-17, third in the AL Central, and has won two in a row after taking Tuesday’s matchup 5-2 behind Drew Romo’s two-homer game. The Angels are still favored at -126, with the White Sox at +106.

The Tampa Bay Rays go for the sweep against the Cleveland Guardians on Wednesday, April 29, 2026, at Progressive Field in Cleveland. First pitch is set for 1:10 PM ET, with light rain and calm crosswinds in the forecast. Tampa Bay enters at 18-11 and riding a six-game winning streak, while Cleveland sits at 15-16 and has dropped four straight after another frustrating night at the plate. The Rays took Tuesday’s meeting 1-0 behind a dominant outing from Nick Martinez and another strong bullpen finish. Cleveland had late traffic but could not cash in, which has become the bigger concern in this series. The Guardians are getting quality pitching, but the offense has not done enough to support it. Drew

The St. Louis Cardinals visit the Pittsburgh Pirates on Wednesday, April 29, 2026, at PNC Park in Pittsburgh, PA. First pitch is set for 6:40 PM ET, with the Cardinals entering at 16-13 and third in the NL Central, while the Pirates are 16-14 and trying to stop a three-game slide. St. Louis has taken the first two games of this series, including an 11-7 win on Tuesday night where the lineup finally looked loud from top to bottom. Pittsburgh still has a solid overall profile, but after allowing 15 runs across the first two games of the series, the pressure shifts to Bubba Chandler and the bullpen to calm things down. The Pirates are favored at -150, with the