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Tampa Bay Rays vs Cincinnati Reds Picks and Predictions April 22nd 2026
Cincinnati goes for a sweep Wednesday afternoon at Tropicana Field, with first pitch set for 1:10 p.m. ET on MLB.TV. The Reds come in at 16-8, first in the NL Central, and they have been excellent away from home at 10-2. Tampa Bay is 12-11, second in the AL East, but only 4-4 at home and trying to stop a three-game slide. Even with the Rays still favored, this feels like one of those spots where recent form and price are pulling in opposite directions. The Reds have already taken the first two games of the series, winning 6-1 on Monday and 12-6 on Tuesday. Cincinnati has now won five straight and is chasing a perfect 6-0 road trip, while
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Cleveland Guardians vs Houston Astros Picks and Predictions April 22nd 2026
Houston heads into Progressive Field for Wednesday’s series finale trying to salvage a split after Tuesday’s 8-5 loss. The Astros are 9-16, last in the AL West, and just 2-10 on the road. Cleveland is 14-11, first in the AL Central, and 8-4 at home. First pitch is set for 1:10 p.m. ET, and the conditions look mild for an April afternoon in Cleveland, with temperatures around 60 degrees and only a light breeze. The game state matters here. Cleveland stole Tuesday’s win with a six-run eighth inning after trailing late, while Houston’s bullpen issues showed up again in a series where the Astros have already asked too much from the relief group. Even so, this is not a simple
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Kansas City Royals vs Baltimore Orioles Picks and Predictions April 22nd 2026
The Orioles and Royals wrap up their three-game set Wednesday afternoon at Kauffman Stadium, with first pitch scheduled for 2:10 p.m. ET. Baltimore comes in at 11-13, third in the AL East, while Kansas City is 8-16 and fifth in the AL Central. The series is tied 1-1 after the Royals stole Tuesday’s game 6-5 on a walk-off wild pitch, and that matters because both teams badly need a clean finish to the series after uneven starts. The recent form is not especially flattering for either side. The Orioles have lost six of their last eight and are 4-6 over their last 10, while the Royals just snapped an eight-game skid and are 2-8 over that same stretch. The weather
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Los Angeles Angels vs Toronto Blue Jays Picks and Predictions April 22nd 2026
The Blue Jays and Angels close out their series Wednesday afternoon at Angel Stadium, with first pitch set for 3:07 p.m. ET. Toronto comes in at 10-13, fourth in the AL East, and has a chance to finish a three-game sweep after taking the first two games 5-2 and 4-2. Los Angeles is 11-14, third in the AL West, and trying to stop a four-game slide. The stream is listed on MLB.TV, and the weather setup in Anaheim looks mild, with intervals of clouds and sun and temperatures in the low 70s. This is an interesting market because the Angels are still favored even though Toronto has won three straight overall and already handled this matchup twice in Anaheim. The
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Seattle Mariners vs Athletics Picks and Predictions April 22nd 2026
The Athletics head into Wednesday’s series finale at T-Mobile Park with a 13-11 record, first place in the AL West, and wins in the first two games of this set. Seattle is 10-15, fourth in the division, and trying to avoid a home sweep after dropping games by 6-4 and 5-2. First pitch is set for 4:10 p.m. ET, with the game listed on MLB.TV. This is a better spot than it might look at first glance for Oakland. The Athletics are 6-4 in their last 10 and 8-6 on the road, while Seattle is 4-6 in its last 10 even though it has played much better at home than away. The Mariners are 9-7 at T-Mobile Park, but their

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Orlando Magic vs. New York Knicks Pick & Prediction FEBRUARY 14th 2024

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The New York Knicks will take the court Wednesday night in the midst of a three-game losing streak. Yet they hope they … more

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Clemson Tigers vs. Miami-Florida Hurricanes Pick & Prediction FEBRUARY 14th 2024

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Following a week of historic road wins, Clemson returns home to face free-falling Miami in Atlantic Coast Conference play on Wednesday night. … more

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Seton Hall Pirates vs. Xavier Musketeers Pick & Prediction FEBRUARY 14th 2024

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In late December, Seton Hall absorbed a 20-point loss at Xavier and responded with five straight wins. With four losses in six … more

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Notre Dame Fighting Irish vs. Georgia Tech Yellow Jackets Pick & Prediction FEBRUARY 14th 2024

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It’s been nearly two years since Notre Dame won back-to-back ACC games. And even longer since Georgia Tech beat the Fighting Irish … more

Penn St. Nittany Lions vs. Michigan St Spartans Pick & Prediction FEBRUARY 14th 2024

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This season’s first matchup between Michigan State and Penn State was heavily one-sided, in favor of the Spartans. The Big Ten rivals … more