| Zac Rosscup (RP) | 06/24/2018 | Early July | Finger | Rosscup has been shifted to the 60-day disabled list dealing with warts on his left middle finger and is likely to stay on the DL until at least the beginning of July. |
| Brandon Morrow (RP) | 06/24/2018 | Out indefinitely | Back | Morrow has been placed on the 10-day disabled list with a lower back injury and it is unknown when he will return to the lineup. |
| Carl Edwards Jr. (RP) | 06/24/2018 | Early July | Shoulder | Edwards Jr. has landed on the 10-day disabled list with inflammation in his right shoulder but is likely to return by the start of July, provided no setbacks happen. |
| Eddie Butler (SP) | 06/24/2018 | Early July | Groin | Butler has been transferred to the 600-day disabled list with a right groin strain and is likely to remain absent from the bullpen until sometime in July. |
| Yu Darvish (SP) | 06/24/2018 | Early July | Tricep | Darvish has been placed on the 10-day disabled list with right triceps tendinitis. He will likely be out of action until the beginning of July. |
| Marco Hernandez (SS) | 06/24/2018 | Early July | Shoulder | Hernandez has been designated for the 60-day disabled list after he had a second procedure on his surgically-repaired left shoulder. He is likely be held out of action until the start of July. |
| Addison Russell (SS) | 06/23/2018 | Prob Sat | Finger | Russell was held out of the last game due to soreness in his left middle finger but is expected to play against the Reds on Saturday. |
| Javier Baez (2B) | 06/23/2018 | Ques Sat | Rest | Baez will not be in the starting lineup for Saturday's game against the Reds as he has been given a day of rest. |
| Kris Bryant (3B) | 06/23/2018 | Ques Sat | Rest | Bryant is absent from the starting lineup for Saturday's contest against the Reds as he will receive a day of rest. |
| Brian Duensing (RP) | 06/22/2018 | Prob Fri | Personal | Duensing is on the bereavement list but is expected to return to the bullpen Friday against the Reds. |
| Javier Baez (2B) | 06/19/2018 | Prob Tues | Elbow | Baez is expected to participate in Game 2 of Tuesday's doubleheader against the Dodgers despite an elbow contusion. |
| Javier Baez (2B) | 06/19/2018 | Ques Tues | Elbow | Baez left the previous game with a left elbow contusion and will not be available for Tuesday's first game of the doubleheader against the Dodgers. It is possible he could return for the second game. |
| Willson Contreras (C) | 06/19/2018 | Ques Tues | Rest | Contreras will not be in the starting lineup for the first game of Tuesday's doubleheader against the Dodgers as he will be given a game to rest. |
| Willson Contreras (C) | 06/19/2018 | Ques Mon | Rest | Contreras is not expected to be available against the Dodgers on Monday due to a routine day of rest. |
| Kris Bryant (3B) | 06/13/2018 | Ques Wed | Rest | Bryant will not be in the starting lineup for Wednesday's matchup against the Brewers as he will be given a day of rest. |
| Willson Contreras (C) | 06/13/2018 | Ques Wed | Rest | Contreras is absent from the starting lineup for Wednesday's game against the Brewers as he will receive a day of rest. |
| Kyle Schwarber (LF) | 06/12/2018 | Ques Tues | Rest | Schwarber is absent from the starting lineup for Tuesday's contest against the Brewers as he will be given a day of rest. |
| Justin Grimm (RP) | 06/12/2018 | Late June | Back | Grimm has landed on the 10-day disabled list with lower back stiffness and is not expected to return to the bullpen until at least the end of June. |
| Willson Contreras (C) | 06/10/2018 | Ques Sun | Rest | Contreras is not expected to be in the starting lineup Sunday against the Pirates as he likely will be given the day to rest. |
| Kyle Schwarber (LF) | 06/08/2018 | Ques Fri | Rest | Schwarber will be absent from the starting lineup for Friday's matchup against the Pirates as he will receive a day of rest. |
| Addison Russell (SS) | 06/08/2018 | Doub Fri | Finger | Russell has been held out of the past three games due to a left middle finger sprain and it is unlikely he will return to action Friday against the Pirates. |
| Willson Contreras (C) | 06/07/2018 | Ques Thurs | Rest | Contreras will be absent from the starting lineup for Thursday's contest against the Phillies as he will receive a day of rest. |
| Anthony Rizzo (1B) | 06/03/2018 | Ques Sun | Rest | Rizzo is not expected to be in the starting lineup Sunday against the Mets as he likely will be given the day to rest. |
| Kris Bryant (3B) | 06/03/2018 | Ques Sun | Rest | Bryant is not expected to be in the starting lineup Sunday against the Mets as he likely will be given the day to rest. |