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NFL Week 5 Picks – Smart Bets Backed by Data and Experience
We’re five weeks into the 2025 NFL season, and the stakes are getting higher. Contenders are separating from pretenders, and our Scores and Stats experts are capitalizing on the latest trends to deliver top-tier betting picks for Week 5.
Want to know which teams offer the best value this week? Our latest NFL picks highlight sharp angles, key injuries, and momentum shifts. Get exclusive access to expert selections, betting models, and performance metrics designed to give you an edge on every line.
2025 NFL Week 5 Schedule
Week 5 brings some intriguing dynamics—revenge games, short weeks, and early-season must-wins. Whether you’re eyeing totals or hunting for a profitable underdog, this slate is packed with opportunity.
It all starts Thursday with a tightly matched Thursday Night Football clash and closes with a prime-time Monday Night Football finish that could have playoff implications. Don’t just watch—wager with confidence using our full Week 5 schedule and expert advice.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, October 2, 2025 | San Francisco @ Los Angeles | 6:15 PM | SoFi Stadium, Inglewood, CA |
| Sunday, October 5, 2025 | Minnesota @ Cleveland | 7:30 AM | Tottenham Hotspur Stadium, London, England |
| Sunday, October 5, 2025 | Las Vegas @ Indianapolis | 11:00 AM | Lucas Oil Stadium, Indianapolis, IN |
| Sunday, October 5, 2025 | New York @ New Orleans | 11:00 AM | Caesars Superdome, New Orleans, LA |
| Sunday, October 5, 2025 | Dallas @ New York | 11:00 AM | MetLife Stadium, East Rutherford, NJ |
| Sunday, October 5, 2025 | Denver @ Philadelphia | 11:00 AM | Lincoln Financial Field, Philadelphia, PA |
| Sunday, October 5, 2025 | Miami @ Carolina | 11:00 AM | Bank of America Stadium, Charlotte, NC |
| Sunday, October 5, 2025 | Houston @ Baltimore | 11:00 AM | M&T Bank Stadium, Baltimore, MD |
| Sunday, October 5, 2025 | Tennessee @ Arizona | 2:05 PM | State Farm Stadium, Glendale, AZ |
| Sunday, October 5, 2025 | Tampa Bay @ Seattle | 2:05 PM | Lumen Field, Seattle, WA |
| Sunday, October 5, 2025 | Detroit @ Cincinnati | 2:25 PM | Paycor Stadium, Cincinnati, OH |
| Sunday, October 5, 2025 | Washington @ Los Angeles | 2:25 PM | SoFi Stadium, Inglewood, CA |
| Sunday, October 5, 2025 | New England @ Buffalo | 6:20 PM | Highmark Stadium, Orchard Park, NY |
| Monday, October 6, 2025 | Kansas City @ Jacksonville | 6:15 PM | EverBank Stadium, Jacksonville, FL |
NFL Handicapping Leaderboard
At this point in the season, the smartest bettors know it’s not about hype—it’s about patterns. Our Top Handicappers have been locked in since preseason, monitoring ATS performance, public betting splits, and coaching tendencies to bring you actionable, no-fluff analysis.
Keep your eye on the leaderboard—it’s evolving every week and giving clear insight into which pros are consistently hitting their picks. Whether you’re flat betting or rolling out parlays, you’ll want to ride with the experts who are already in mid-season form.
NFL Week 5 Picks
Check out our full rundown of NFL Week 5 betting predictions, including detailed spreads, totals, and moneyline evaluations. Whether you play it safe or go bold, our insights are built to help you cash tickets.
Score Big This Week with Scores and Stats NFL Experts
Success in Week 5 is all about timing—and timing starts with the right information. Our experts combine years of betting experience with data-driven projections to help you navigate every game with confidence.
Get even more insight by following us on Instagram @scoresandstats, connecting with us on X @scoresand_stats, and subscribing on YouTube for breakdowns, trends, and weekly betting advice straight from the source.
From the latest NFL odds to expert-written game previews, we’re here to keep you sharp, informed, and ahead of the betting public. Let Scores and Stats guide your NFL journey all the way to the postseason.
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