Week 6 Thursday Night Football Odds: 49ers vs. Seahawks

Week 6 begins with another divisional matchup as the Seattle Seahawks host the San Francisco 49ers in a juicy NFC West showdown. This marks the 5^th consecutive divisional game for Thursday Night Football, and it feels like the NFL has found a winning formula for creating compelling matchups on TNF.

Both teams come into this week’s game having lost home contests that they were favored to win in Week 5. The Seattle Seahawks blew a late-game comeback and fell at home to the New York Giants. It was the worst performance by Seattle this season.

The San Francisco 49ers allowed Arizona to comeback from a two-point deficit to kick the game winning field goal with 90 seconds left in the game. Making matters worse, the 49ers had the ball with plenty of time to go down the field and kick their own FG to win the game. Instead, Brock Purdy threw an interception and San Francisco loses to a vastly inferior team.

With the way these two teams are playing as of late, neither has the clear-cut advantage for this TNF game. That means it should be an entertaining matchup for fans and bettors alike.

Let’s dive deeper into the latest NFL odds, courtesy of the top sports betting sites, and make our Week 6 NFL Predictions for the San Francisco 49ers vs. Seattle Seahawks.

What Channel Is Thursday Night Football On?

• Thursday Night Football Channel: Amazon Prime Video
• Thursday Night Football Time: 8:15 p.m. EST
• Thursday Night Football Announcers: Al Michaels and Kirk Herbstreit 

Thursday Night Football Betting 

Keep an eye on the latest NFL odds for TNF and monitor how the lines change throughout the week.

It’s not a surprise that the 49ers opened as a sizable betting favorite at -218 odds. Their line climbed to a high of -230 during preseason action, before slowly declining. They reached a low of -160 prior to the Week 5 action, before slowly climbing back up to a range around the current -180 line.

Seattle opened as a +180 underdog, went as high as +190, lowered to +135 during last Sunday’s games, before climbing back up to the current range of around +150.

The spread opened with the 49ers favored by five points. However, it has slowly lowered to the current line of -3 points in favor of San Francisco. Some sportsbooks might fluctuate a half point either way.

The Total opened at 46.5 points, rose as high as 48.5 points, before settling at the current Over/Under of 47.5 total points.

Thursday Night Football Odds

The following Thursday Night Football odds are courtesy of ScoresandStats:

These two divisional rivals have played against each other 52 total times. The Seattle Seahawks lead the series with a 30-22 all-time record. However, the San Francisco 49ers have won five consecutive games against Seattle. In fact, they’ve swept the Seahawks the last two years, which includes a 2023 Wild Card game.

The 49ers have also won three of the last five matchups in Seattle, which includes winning the last two games at the Seahawks. They outscored Seattle 52 to 26 in those two games.

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Thursday Night Football Betting Trends

Check out the following San Francisco 49ers vs. Seattle Seahawks betting trends:

49ers vs. Seahawks Betting Trends

• The 49ers are 5-0 SU In the last five meetings
• The 49ers are 4-1 ATS in last 5 matchups
• The Over is 5-4-1 in last 10 contests
• The 49ers are 3-10 SU in last 13 games at Seattle

San Francisco 49ers Betting Trends

• 2-4 SU in last six games
• 3-10 SU in last 13 games at Seattle
• 2-5 SU in last seven Week 6 games
• 0-2 ATS in Road games this year
• 2-7 ATS in last nine games
• 0-6 ATS in last six NFC games
• 1-4 ATS in last five October games
• Over is 5-2 in last seven games
• Over is 8-2 in last 10 NFC West games

Seattle Seahawks Betting Trends

• 6-3 SU in last nine games
• 2-6 SU in last eight NFC games
• 2-1 ATS in Home games this year
• 1-5-1 ATS in last seven games
• 9-3-1 ATS in last 13 October games
• 4-1 ATS in last five Week 6 games
• Over is 4-1 in their five games this season
• Over is 6-2 in last eight Home games
  

Thursday Night Football Predictions

Let’s take a closer look at some of the key matchups for this game as we make our NFL Thursday Night Football predictions. NFL stats are courtesy of TeamRankings and Pro Football Reference.

49ers Offense vs. Seahawks Defense

It’s rather surprising that the San Francisco 49ers have a Top 10 offense in just about every major statistical category, but they sit at 2-3 on the season. Even more alarming than that, is the fact that the 49ers are 0-2 in the NFC West division after five weeks of the season.

Losing at Minnesota is one thing, but losing to the Los Angeles Rams and Arizona Cardinals by giving up last-minute scores, is just un-San Francisco like. Yes, the 49ers are dealing with injuries on both sides of the ball, but they still have a number of elite playmakers on both sides of the ball, especially the offense.

Christian McCaffrey has yet to play this season, but Jordan Mason has filled in admirably. He’s tallied 536 rushing yards, which breaks down to 107.2 ypg. As a team, the 49ers are 7^th in the league with 144 rushing yards per game. The Seahawks give up 128 ypg on the ground, so there’s definitely room for the 49ers to find success running the ball this week.

The marquee matchup for this divisional battle is the 49ers passing game versus the Seahawks pass defense. San Francisco is 4^th in the league with 263.4 ypg and Seattle is 7^th against the pass at 183 ypg. However, they just gave up 257 passing yards to Daniel Jones last weekend. Purdy is a far better QB than Jones is.

Additionally, Seattle gave up 292 passing yards to Detroit QB Jared Goff in Week 4. I expect Purdy to have a solid performance this week as he finishes somewhere between the totals of Jones and Goff.

Seahawks Offense vs. 49ers Defense

It’s safe to say that the 49ers defense has been a huge disappointment this season after five weeks. They’re giving up 21.2 ppg, but have dropped two of their last three contests due to allowing the opposition to score at the end of the games and win.

Furthermore, giving up 24 points to the Cardinals and 27 points to the Rams is inexcusable. These aren’t good teams right now. Arizona is 2-3 on the season and the Rams are 1-4. The latter is dealing with some major injuries to their top offensive playmakers. They don’t have the wealth of talent that the 49ers do.

Seattle’s offense has been surprisingly good this year. They’ve exceeded many preseason expectations, especially in their passing game. For starters, Seatle averages 24.4 ppg (11^th), 376.2 total yards per game (2^nd), and 270.8 passing yards per game (3^rd).

They’re also Top 10 in red zone scoring percentage for TDs (10^th), TDs per game (9^th), yards per play (9^th), and rushing TDs per game (4^th).

The key matchup here, is the 49ers pass defense against this elite Seattle passing offense which is statistically as good as San Francisco’s passing attack. The 49ers allow just 197 passing yards per game, which is 12^th best in the league. However, they are 5^th in sacks and 10^th in interception percentage.

The 49ers will need to create a pass rush to disrupt Geno Smith’s timing and comfort in the pocket. They have the tools to do this. Unfortunately, in their three losses, this highly touted San Francisco pass rush has failed to accomplish this for all four quarters.

Seattle’s running game trails their passing attack, but it’s not because of a lack of talent or execution. It comes down to the fact that they throw the ball more than any other team in the league.

The Seahawks have a solid, young RB in Kenneth Walker, but they only run the ball 21 times a game which is dead last in the league. This is surprising considering that Seattle ranks 7^th with an average 5.0 yards per carry. They only run the ball 32.6% of the time.

Who Wins TNF: 49ers or Seahawks?

The 49ers offense scores 25.2 ppg and the Seahawks defense gives up 22.8 ppg. San Francisco has scored at least 23 points in four of their five games. Seattle has given up at least 20 points in four of their last five games.  

On the flip side, Seattle scores 24.4 ppg and the 49ers give up 21.2 ppg. Even in their two defeats, Seattle averaged 24.5 ppg. In the 49ers three losses, they gave up just under 25 ppg.

So, I see this game going Over 47.5 points as both teams will score the ball. Neither defense is playing lights out, or stopping the opposition when it really matters.

Considering the 49ers have already lost two divisional matchups, I think Seattle has a real shot this week at sending San Francisco to a surreal 0-3 NFC West record.

I like the value we’re getting with Seattle, especially the points. If you can find them at +3.5, that would be fantastic.

Turnovers will be crucial in this matchup. Giving extra possessions to great offenses is a recipe for disaster in this matchup.

With that said, I think the most overlooked aspect of this game is Seattle’s running backs. Walker and Zach Charbonet are a formidable 1-2 punch. Additionally, they can both catch out of the backfield. Look for this duo to be the difference maker in this contest and help Seattle cover the spread, while flirting with winning the game outright. Currently, some of the best handicappers are rolling with Seattle and the pints.

Bet: Seattle Seahawks +3 (-110), Over 47.5 points (-110)

Thursday Night Football Prop Bets

Check out our picks for the best San Francisco 49ers vs. Seattle Seahawks Game and Player Prop bets:

Kenneth Walker Anytime TD (-138)

Walker has only played in three of the five games so far. He missed two games due to an injury. Charbonet was able to provide Seattle with the running success they needed. However, when Walker does play, he’s averaging 1.3 TDs per game.

Walker gets the goal line carries, but he also gets passes out of the backfield in the red zone. If there’s one Seattle player that I feel confident in scoring a TD versus the 49ers, it’s Walker.

Bet: Kenneth Walker Anytime TD (-138)

Kenneth Walker Rushing Yards

• Over 55.5 yards (-110)
• Under 55.5 yards (-110)

Continuing our Kenneth Walker theme, the talented running back has 202 rushing yards in his three games played this season. That’s an average of 67.3 yards per game. Last weekend, the Seahawks foolishly gave Walker just five carries in their game versus the New York Giants. I would like to point out that this isn’t a running back problem; this is a scheme imbalance.

Walker is averaging 5.5 yards per carry. Let that number sink in again. If Seattle gives him at least 12-15 rushes this week against the 49ers, I see Walker easily eclipsing 55 rushing yards. I like this prop bet, but I would put a small wager on it because the Seattle play caller tends to forget they actually have talented running backs.

Bet: Over 55.5 yards (-110)

Brock Purdy Passing Yards

• Over 249.5 yards (-110)
• Under 249.5 yards (-110)

Seattle’s pass defense looks good on paper as they give up just 183 passing yards per game. However, that’s a bit misleading as the Seahawks allowed Daniel Jones to throw for 257 yards last weekend.

The 49ers’ passing attack is 4^th in the NFL with an average of 263.4 ypg. Brock Purdy has 1,374 passing yards this season, which breaks down to 274.8 passing yards per game.

In three of the five games this year, Purdy threw for 288 yards or more. Last weekend against the Cardinals, Purdy has his worst statistical game of the season when he completed just 54.3% of his passes and threw two INTs. Yet, he still finished with 244 yards.

I see Purdy going well beyond the 250-yard threshold and having a much better performance this week than he did last week.

Bet: Over 249.5 yards (-110).

Deebo Samuel Receiving Yards

• Over 53.5 yards (-110)
• Under 53.5 yards (-110)

Deebo Samuel was a non-factor in the game against the Cardinals. He hast just one catch on three targets. Additionally, he only had three carries. These are his lowest numbers on the season. Despite that dud, Samuel is still averaging 58.3 receiving yards per game.

In his three games prior to the Arizona matchup, Samuel had at least 54 receiving yards in all of those contests. He was targeted an average of eight times per game in those matchups.

I see the 49ers focusing on getting Samuel more involved this week. Look for Samuel to get at least 54 receiving yards and 20 rushing yards against the Seahawks.

Bet: Over 53.5 yards (-110)

Jordan Mason Rushing Yards

• Over 80.5 yards (-110)
• Under 80.5 yards (-110)

Currently, Jordan Mason is second in the league for rushing with 536 yards in five games. He’s just 36 yards behind league leader Derrick Henry, and 101 yards ahead of third-place Saquon Barkley.

Mason is averaging 107.5 rushing yards per game on 5.1 yards per carry. His lowest output on the season was against the Rams in Week 3 when he finished with 77 yards. Even though he had his lowest attempts last weekend versus the Cardinals, Mason still tallied 89 rushing yards.

He’s eclipsed the 100-yard mark in three of his five games. Seattle allows 120 rushing yards per game, which bodes well for Mason and the 49ers. Take the Over.

Bet: Over 80.5 yards (-110)

Jason Meyers Scoring

• Over 6.5 points (-110)
• Under 6.5 points (-110)

Last, but not least, we have to include a Kicker on our list of player prop bets. They seem to be overlooked quite often, but they offer some solid value when it comes to their scoring output.

On the season, Jason Meyers has eight field goals and 12 PATs for 36 total points. This breaks down to an average of 7.2 ppg.

In three of his five games, Meyers scored eight or more points. In the two games he didn’t, it was due to missing field goals. Although, the Detroit game in Week 4, saw Meyers attempt just one FG despite the Seahawks scoring 29 points.

San Francisco allows the opposition a 90.91% field goal conversion rate. I expect Seattle to get into the red zone on multiple drives and come away with field goals. Take the Over as Meyers is a sneaky play this week.

Bet: Over 6.5 points (-110)

Best Bets For Thursday Night Football

The Best Bets for Thursday Night Football are as follows:

• Seattle Seahawks +3 (-110)
• Brock Purdy over 249.5 passing yards (-110)
• Jordan Mason over 80.5 rushing yards (-110)

Right now, the 49ers are wildly inconsistent and losing games that they shouldn’t. They’re also 0-2 on the road and 0-2 in the division. Although I slightly lean towards them to win this game, I don’t think it will be by more than a FG. In fact, I’m jumping on a Seattle line of +3.5 points when it hopefully goes that high.

Brock Purdy throwing for over 250 yards is probably my favorite wager for the entire game. It’s definitely my favorite prop bet, just edging out Jordan Mason’s rushing yards.

Purdy is averaging 274.8 passing yards per game. The team is averaging 263.4 passing yards per game. The Seahawks gave up a season high 292 passing yards to Jared Goff and just allowed 257 passing yards to Daniel Jones last Sunday.

Even in Purdy’s worst statistical game of the season, which was last weekend against the Cardinals, he still finished with 244 yards. I see the young, franchise QB easily eclipsing 250 passing yards this Thursday against the Seahawks.

Seattle gives up 128 rushing yards per game and the 49ers average 144 rushing yards per game. Jordan Mason is second in the league with 536 rushing yards, while averaging 107.2 rushing yards per game.

This is a juicy matchup for Mason who should eclipse the 100-yard mark for the fourth time this year. this week. He’s averaging just 2.8 yards per carry and 28.8 rushing yards per game. He’s being outplayed by Irving who should get more rushes this week as White morphs into more of a passing down back.

Thursday Night Football Schedule

Check out the complete Thursday Night Football schedule along with our predictions for each week: