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NFL Week 2 Odds are now live for all 16 games from Thursday, September 17 through Monday, September 21. Week 1 gave bettors actual evidence to work with, but the bigger Week 2 edges come from price and availability. Seattle quarterback Sam Darnold is expected to miss the Arizona game, Minnesota quarterback Kyler Murray is in concussion protocol, New England is without A.J. Brown, and the Rams have lost Myles Garrett to injured reserve. Arizona +4 is the early ScoresAndStats best bet, while Kansas City -6.5 is the preferred favorite.
The goal is not to chase every Week 1 result. One game remains a tiny sample. The useful approach is separating information that can repeat, such as injuries, quarterback availability and market position, from noisy results that may not.
For game-specific updates throughout the week, compare the latest NFL predictions and live odds. Bettors reviewing what changed can also revisit the NFL Week 1 odds and predictions.
NFL Week 2 odds, picks and predictions
Every Week 2 game with the line the sportsbooks are posting, our pick on it, and a link to the full prediction. Prices are the median across the books quoting each game, read 18 September 2026.
| Kickoff | Game | Spread | Total | Our pick | Result |
|---|---|---|---|---|---|
| Thu 17 Sep, 8:15 PM ET | Detroit Lions at Buffalo Bills | — | — | Detroit +5.5 | Detroit Lions 31 at Buffalo Bills 41 |
| Sun 20 Sep, 1:00 PM ET | Carolina Panthers at Atlanta Falcons | Atlanta Falcons +2.5 (11 books) | 44 | Atlanta +2.5 | — |
| Sun 20 Sep, 1:00 PM ET | Cincinnati Bengals at Houston Texans | Houston Texans -2.5 (11 books) | 46 | Houston moneyline and Under 46 | — |
| Sun 20 Sep, 1:00 PM ET | Cleveland Browns at Tampa Bay Buccaneers | Tampa Bay Buccaneers -8.5 (11 books) | 41.5 | Cleveland +8.5 | — |
| Sun 20 Sep, 1:00 PM ET | Green Bay Packers at New York Jets | New York Jets +3.5 (11 books) | 44.5 | Green Bay -3.5 | — |
| Sun 20 Sep, 1:00 PM ET | Minnesota Vikings at Chicago Bears | Chicago Bears -4.5 (11 books) | 48 | Minnesota +4.5 | — |
| Sun 20 Sep, 1:00 PM ET | New Orleans Saints at Baltimore Ravens | Baltimore Ravens -8.5 (11 books) | 46.5 | New Orleans +8.5, New Orleans moneyline for a quarter unit, and Under 47 | — |
| Sun 20 Sep, 1:00 PM ET | Philadelphia Eagles at Tennessee Titans | Tennessee Titans +7 (11 books) | 39.5 | Over 39.5 | — |
| Sun 20 Sep, 1:00 PM ET | Pittsburgh Steelers at New England Patriots | New England Patriots -5 (11 books) | 41.5 | no bet (pass at New England -5) | — |
| Sun 20 Sep, 4:05 PM ET | Jacksonville Jaguars at Denver Broncos | Denver Broncos -2.5 (11 books) | 45.5 | Jacksonville +2.5 | — |
| Sun 20 Sep, 4:05 PM ET | Las Vegas Raiders at Los Angeles Chargers | Los Angeles Chargers -6.5 (11 books) | 43.5 | Las Vegas +6.5 | — |
| Sun 20 Sep, 4:25 PM ET | Miami Dolphins at San Francisco 49ers | San Francisco 49ers -13 (11 books) | 45 | Miami +13.5 | — |
| Sun 20 Sep, 4:25 PM ET | Seattle Seahawks at Arizona Cardinals | Arizona Cardinals +4 (11 books) | 41 | Seattle -4 | — |
| Sun 20 Sep, 4:25 PM ET | Washington Commanders at Dallas Cowboys | Dallas Cowboys -4 (11 books) | 50.5 | Washington +4 and Over 50.5 | — |
| Sun 20 Sep, 8:20 PM ET | Indianapolis Colts at Kansas City Chiefs | Kansas City Chiefs -6.5 (10 books) | 46.5 | Kansas City -6.5 | — |
| Mon 21 Sep, 8:15 PM ET | New York Giants at Los Angeles Rams | Los Angeles Rams -7 (11 books) | 48 | New York +7 | — |
NFL Week 2 Betting Takeaways
- ScoresAndStats Best Bet: Arizona Cardinals +4 against Seattle.
- Best Favorite: Kansas City Chiefs -6.5 against Indianapolis.
- Best Key-Number Underdog: New York Giants +7 against the Rams.
- Best Total: Miami Dolphins-San Francisco 49ers Under 45.
- Important wait spot: Atlanta +2.5 depends on the Falcons’ quarterback situation.
NFL Week 2 Odds 2026
The official NFL Week 2 schedule contains 16 games and no byes. The Thursday opener sends Detroit to Buffalo, while the Giants-Rams matchup closes the week Monday night.
| Matchup | Current Spread | Total |
|---|---|---|
| Lions at Bills, Thu. 8:15 PM ET | Buffalo -4.5 (-112) | 53.5 |
| Panthers at Falcons, Sun. 1:00 PM ET | Carolina -2.5 (-110) | 43 |
| Bengals at Texans, Sun. 1:00 PM ET | Houston -2.5 (-116) | 46.5 |
| Browns at Buccaneers, Sun. 1:00 PM ET | Tampa Bay -9 (+103) | 41.5 |
| Packers at Jets, Sun. 1:00 PM ET | Green Bay -3.5 (-105) | 45 |
| Vikings at Bears, Sun. 1:00 PM ET | Chicago -5.5 (-105) | 48.5 |
| Saints at Ravens, Sun. 1:00 PM ET | Baltimore -9 (+101) | 47 |
| Eagles at Titans, Sun. 1:00 PM ET | Philadelphia -7 (-108) | 39.5 |
| Steelers at Patriots, Sun. 1:00 PM ET | New England -5.5 (-103) | 41.5 |
| Jaguars at Broncos, Sun. 4:05 PM ET | Denver -2.5 (-114) | 44.5 |
| Raiders at Chargers, Sun. 4:05 PM ET | Los Angeles -7 (+100) | 43.5 |
| Dolphins at 49ers, Sun. 4:25 PM ET | San Francisco -13.5 (+100) | 45 |
| Seahawks at Cardinals, Sun. 4:25 PM ET | Seattle -4 (-106) | 41 |
| Commanders at Cowboys, Sun. 4:25 PM ET | Dallas -3.5 (-112) | 50.5 |
| Colts at Chiefs, Sun. 8:20 PM ET | Kansas City -6.5 (-110) | 47 |
| Giants at Rams, Mon. 8:15 PM ET | Los Angeles -7 (-105) | 48.5 |
Key numbers matter immediately. Packers bettors are laying 3.5 rather than three. Kansas City is still available below seven. The Giants are getting a full touchdown. Las Vegas is also sitting at +7 in a division game. Those half-points and full key numbers are more important than a small difference in juice.
What Week 1 Changed for Bettors
Week 1 produced extreme results at both ends of the board. Chicago scored 59 points at Carolina, Baltimore put 41 on Indianapolis and Kansas City controlled Denver 31-10. San Francisco also beat the Rams 27-7 after entering as an underdog, while Arizona upset the Chargers 26-14.
Those results matter, but not equally. Chicago’s offensive ceiling deserves an upgrade, but 59 points should not become a new baseline. Kansas City’s 220 rushing yards and Kenneth Walker III’s 173-yard debut give opponents a repeatable problem because they reduce the amount of pressure Patrick Mahomes must absorb. Arizona’s defensive performance is more relevant this week because Seattle is preparing to use a backup quarterback.
New England’s 13-10 loss to Seattle is another example. The Patriots controlled stretches of the game but Drake Maye threw interceptions on the team’s final three possessions. That is not proof that Maye will remain turnover-prone, but losing A.J. Brown from an already limited passing attack changes the Week 2 handicap.
The biggest rule for this card is simple: use Week 1 to update the price, not to erase everything believed before Week 1.
NFL Week 2 Injury and Availability Watch
Several important Week 2 statuses remain unsettled on September 15. These are market catalysts, not details to ignore until Sunday morning.
| Team / Player | Current Status | Betting Impact |
|---|---|---|
| Seattle QB Sam Darnold | Expected to miss Week 2 | Supports Arizona +4 |
| Minnesota QB Kyler Murray | Concussion protocol | Makes +5.5 price-sensitive |
| New England WR A.J. Brown | Expected to miss multiple weeks | Supports Pittsburgh +5.5 |
| Rams OLB Myles Garrett | Knee surgery, injured reserve | Weakens Rams -7 case |
| Atlanta quarterbacks | Week 2 starter not confirmed | Wait before betting Falcons |
| Baltimore WR corps | Ja’Kobi Lane out several weeks; Zay Flowers day-to-day | Improves Saints +9 price |
NFL Week 2 Picks and Predictions
Thursday, September 17 · 8:15 PM ET
Interconference
ScoresAndStats Pick: Detroit +5.5. Buffalo was -3 on Sunday night and is -5.5 now. Take Detroit and the points. Detroit Lions at Buffalo Bills Prediction
Detroit survived New Orleans 31-30 in Week 1, while Buffalo beat Houston 36-31. That gives the market two offenses that immediately showed they can finish drives and two defenses that allowed at least 30 points.
The short week is the main risk to an over because neither staff gets a normal installation window. The counter is that both offenses can lean on concepts already used successfully four days earlier instead of building a completely new plan.
Sunday, September 20 · 1:00 PM ET
Divisional
ScoresAndStats Pick: Atlanta +2.5. Carolina gave up 59 at home and is now favoured on the road. I want Atlanta and the points. Carolina Panthers at Atlanta Falcons Prediction
Carolina allowed 59 points and 552 total yards to Chicago, including 291 rushing yards. That makes it difficult to endorse the Panthers as a road favorite based on one week of market movement.
Atlanta’s problem is quarterback availability. Cooper Rush started the 20-13 loss at Pittsburgh after Tua Tagovailoa was ruled out and Michael Penix Jr. remained unavailable. The Falcons had not announced their Week 2 starter as of this update.
Sunday, September 20 · 1:00 PM ET
Conference
ScoresAndStats Pick: Houston moneyline and Under 46. Houston went 7-2 at home last season. Take the Texans to win, and take the under. Cincinnati Bengals at Houston Texans Prediction
Cincinnati opened with a 33-27 win over Tampa Bay. Houston scored 31 in its loss to Buffalo. A total of 46.5 asks both offenses for considerably less than they produced in Week 1.
The obvious risk is paying for last week’s scoring. That concern is real, but neither defense showed enough in the opener to justify immediately expecting a major correction.
Sunday, September 20 · 1:00 PM ET
Interconference
ScoresAndStats Pick: Cleveland +8.5. Tampa Bay won by nine or more twice in 17 games last season. Take Cleveland +8.5. Cleveland Browns at Tampa Bay Buccaneers Prediction
Cleveland is staying with Deshaun Watson after a 34-10 loss at Jacksonville. Watson completed 16 of 22 passes for 205 yards, but much of Cleveland’s production arrived after the game had already tilted heavily toward the Jaguars.
Tampa Bay scored 27 against Cincinnati and now gets a Cleveland offense that struggled to sustain drives. Laying nine is uncomfortable, but getting plus money on the favorite helps compensate for the backdoor risk.
Sunday, September 20 · 1:00 PM ET
Interconference
ScoresAndStats Pick: Green Bay -3.5. Green Bay was -5.5 on 13 September and is -3.5 now. Take the Packers at -3.5. Green Bay Packers at New York Jets Prediction
Green Bay lost 39-22 at Minnesota. New York beat Tennessee 23-10. The market still asks Jets bettors to take more than a field goal at home, which is the part of this matchup that matters most.
Green Bay can rebound without making -3.5 attractive. A three-point Packers victory still cashes the Jets ticket, and that protection disappears if the number falls to +3.
Sunday, September 20 · 1:00 PM ET
Divisional
ScoresAndStats Pick: Minnesota +4.5. Their last two meetings were decided by 3 and by 2. I want Minnesota and the points. Minnesota Vikings at Chicago Bears Prediction
Chicago’s 59-point opener will attract attention, but this spread already charges bettors for it. Minnesota beat Green Bay 39-22 despite losing Kyler Murray to a concussion in the first quarter.
Murray’s availability is the catalyst. The important betting point is that Minnesota showed it could survive the quarterback change, while a division underdog getting 5.5 provides room for the Bears to win without covering.
Sunday, September 20 · 1:00 PM ET
Interconference
ScoresAndStats Pick: New Orleans +8.5, New Orleans moneyline for a quarter unit, and Under 47. New Orleans is getting 8.5 in Baltimore. Take the Saints and the points. New Orleans Saints at Baltimore Ravens Prediction
Baltimore looked dominant in a 41-23 win at Indianapolis, but the market has pushed the Ravens to nine points. New Orleans was much more competitive than its price suggested in a 31-30 loss at Detroit.
Baltimore also enters the week with receiving depth concerns. Ja’Kobi Lane is expected to miss several weeks with a fractured wrist, and Zay Flowers is day-to-day with a hamstring issue. Derrick Henry and Lamar Jackson can still break the handicap, but nine points gives New Orleans meaningful protection.
Sunday, September 20 · 1:00 PM ET
Interconference
ScoresAndStats Pick: Over 39.5. The total has dropped from 42.5 to 39.5. Take the over. Philadelphia Eagles at Tennessee Titans Prediction
Philadelphia won its opener 24-22 against Washington, while Tennessee lost 23-10 to the Jets. The Eagles deserve to be favored, but the combination of a seven-point spread and a 39.5 total creates a different betting question.
When the market expects fewer than 40 combined points, a full touchdown becomes more valuable. Tennessee does not need to match Philadelphia’s roster quality to stay inside seven.
Sunday, September 20 · 1:00 PM ET
Conference
ScoresAndStats Pick: no bet (pass at New England -5). New England -5 is where last season puts this game. No bet on the spread. Pittsburgh Steelers at New England Patriots Prediction
Pittsburgh won 20-13 against Atlanta, while New England lost 13-10 to Seattle after throwing three fourth-quarter interceptions. The Patriots defense played well enough to keep that opener close, but their offense now loses another major piece.
A.J. Brown is expected to miss multiple weeks with a high ankle sprain. Asking New England to win by six against a Pittsburgh team that already demonstrated it can play a low-possession game is too aggressive.
Sunday, September 20 · 4:05 PM ET
Conference
ScoresAndStats Pick: Jacksonville +2.5. Jacksonville won by 14 in Denver last December. I want the Jaguars and the points. Jacksonville Jaguars at Denver Broncos Prediction
This is the cleanest buy-low versus sell-high decision on the Sunday afternoon card. Jacksonville beat Cleveland 34-10. Denver lost 31-10 at Kansas City and produced only 176 total yards.
Yet Denver is still favored by 2.5 at home. That market position matters. Kansas City is a much tougher opponent than Cleveland, and one poor night should not erase the preseason case for Denver’s defense or the advantage of playing in altitude.
Sunday, September 20 · 4:05 PM ET
Divisional
ScoresAndStats Pick: Las Vegas +6.5. Los Angeles won by 7 or more in three of its eight home games last season. Take the Raiders and 6.5. Las Vegas Raiders at Los Angeles Chargers Prediction
Las Vegas beat Miami 27-13. The Chargers lost 26-14 as a heavy Week 1 favorite against Arizona. Los Angeles may still have the higher season-long ceiling, but a full touchdown is a large price in an AFC West matchup.
The Raiders do not need to prove their Week 1 performance is completely sustainable. They need to keep a division game within seven points, which is a much lower bar.
Sunday, September 20 · 4:25 PM ET
Interconference
ScoresAndStats Pick: Miami +13.5. San Francisco did not win a home game by 14 or more in 2025. Take Miami +13.5. Miami Dolphins at San Francisco 49ers Prediction
San Francisco delivered one of Week 1’s strongest performances by beating the Rams 27-7 in Melbourne. Miami managed only 13 points in a 27-13 loss at Las Vegas.
The 49ers can control this game without needing to cover a 13.5-point spread. Their Week 1 formula combined efficient offense, 174 rushing yards and a defense that kept Los Angeles from generating explosive scoring. That points toward the total rather than a huge favorite.
Sunday, September 20 · 4:25 PM ET
Divisional
ScoresAndStats Pick: Seattle -4. Seattle won eight of its nine road games last season. I want the Seahawks, laying 4. Seattle Seahawks at Arizona Cardinals Prediction
Arizona +4 is the strongest number on the current Week 2 card. The Cardinals opened with a 26-14 upset of the Chargers, while Seattle needed three fourth-quarter interceptions to escape New England 13-10.
The larger issue is quarterback availability. Sam Darnold is expected to miss Week 2 with the hip injury he suffered after only five plays in the opener. Drew Lock was effective in relief, but Seattle is now laying four on the road with a backup quarterback against a team that just won outright as a large underdog.
Sunday, September 20 · 4:25 PM ET
Divisional
ScoresAndStats Pick: Washington +4 and Over 50.5. Dallas won by more than four at home once last season. Take Washington +4 and the over. Washington Commanders at Dallas Cowboys Prediction
Washington lost 24-22 to Philadelphia. Dallas lost 28-20 at the Giants. The Cowboys receive home-field respect here, but -3.5 asks them to clear the most important spread number after a Week 1 performance that did not justify an upgrade.
Washington does not need to win the NFC East argument in September. It only needs to keep another division game within a field goal.
Sunday, September 20 · 8:20 PM ET
Conference
ScoresAndStats Pick: Kansas City -6.5. When Kansas City wins at home, it tends to win big. Lay the 6.5 with the Chiefs. Indianapolis Colts at Kansas City Chiefs Prediction
Kansas City supplied one of the most important Week 1 upgrades. The Chiefs beat Denver 31-10 while rushing for 220 yards, and Kenneth Walker III produced 173 rushing yards in his debut.
Indianapolis allowed 41 points to Baltimore. The concern with backing Kansas City is obvious recency bias, but the current -6.5 still sits below the key number of seven. A productive ground game also makes the Chiefs less dependent on Mahomes creating every scoring drive himself.
Monday, September 21 · 8:15 PM ET
Conference
ScoresAndStats Pick: New York +7. Los Angeles lost by 20 in Week 1 and still lays 7. Take the Giants and the points. New York Giants at Los Angeles Rams Prediction
The Rams are being asked to lay seven after a 27-7 loss to San Francisco. New York, meanwhile, opened with a 28-20 division win over Dallas.
The injury adjustment strengthens the underdog case. Myles Garrett is headed to injured reserve after knee surgery and will miss at least four games. Los Angeles can rebound offensively, but a full touchdown is too much to lay while its defensive front is being reshuffled.
Best NFL Week 2 Bets
| Rank | Week 2 Bet | Playable Price |
|---|---|---|
| 1 | Arizona Cardinals +4 | +3.5 or better |
| 2 | Pittsburgh Steelers +5.5 | +4.5 or better |
| 3 | New York Giants +7 | Prefer +7 |
| 4 | Kansas City Chiefs -6.5 | -6.5 or better |
| 5 | New Orleans Saints +9 | +8.5 or better |
| 6 | Dolphins-49ers Under 45 | 44.5 or higher |
Arizona is the preferred Week 2 position because the price and quarterback situation point in the same direction. Seattle can still win with Drew Lock, but asking a backup-led road team to cover four points against a 1-0 division opponent creates more risk than the spread acknowledges.
Pittsburgh and New York provide key-number protection against favorites dealing with important personnel losses. Kansas City is the opposite case: the Chiefs are the favorite worth backing because -6.5 still avoids seven and Week 1 showed an additional way for the offense to control games.
Several other picks are number-dependent. Jets +3.5, Raiders +7, Titans +7 and Commanders +3.5 all lose meaningful value if the market moves through their current key number. Getting the right side of three and seven matters more than being able to say a bet was placed early.
NFL Week 2 Odds FAQs
When is NFL Week 2 in 2026?
NFL Week 2 begins Thursday, September 17 with Detroit at Buffalo and runs through Monday, September 21, when the Giants visit the Rams. All 32 teams are scheduled to play.
What is the best NFL Week 2 bet?
Arizona +4 against Seattle is the ScoresAndStats best Week 2 bet at the current price. Sam Darnold is expected to miss the game, making four points attractive with the home underdog.
What is the best NFL Week 2 favorite?
Kansas City -6.5 against Indianapolis is the preferred favorite. The Chiefs beat Denver 31-10 in Week 1 and the current spread remains below the key number of seven.
Are any NFL teams on a bye in Week 2?
No. All 32 NFL teams are scheduled to play in Week 2, producing a full 16-game slate from September 17 through September 21.
What is the biggest NFL Week 2 spread?
San Francisco is currently the largest Week 2 favorite at -13.5 against Miami. ScoresAndStats prefers Under 45 rather than laying nearly two touchdowns with the 49ers.
Which Week 2 injuries matter most for bettors?
Seattle quarterback Sam Darnold is expected to miss Week 2, Minnesota quarterback Kyler Murray is in concussion protocol, New England receiver A.J. Brown is expected to miss multiple weeks and Rams pass rusher Myles Garrett is headed to injured reserve. Atlanta’s quarterback situation also remains an important market catalyst.
