NFL Previews 
MLB Previews 
NBA Previews 
NHL Previews 
Soccer Previews 
NFL Week 6 Picks – Value Plays, Upsets, and Expert Edges
Week 6 is where NFL seasons start to turn. Some teams are surging, others are stumbling—and our experts at Scores and Stats are here to help you capitalize on it all. From sharp line movements to quiet trends flying under the radar, this is the week to dig in and get serious about your picks.
Want the inside scoop on where the value lies? Our NFL picks deliver handpicked selections from seasoned pros who have been studying the tape, watching the numbers, and sniffing out soft lines all season long.
2025 NFL Week 6 Schedule
Week 6 features some juicy matchups with playoff implications already bubbling beneath the surface. Whether you’re targeting defensive mismatches, QB battles, or high-scoring shootouts, this week’s board is full of betting opportunities just waiting to be seized.
Kick things off Thursday night with a must-watch TNF matchup and ride the action through Sunday into a statement-making Monday Night Football finale. Don’t just watch—strategize, wager, and win with our full Week 6 coverage.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, October 9, 2025 | Philadelphia @ New York | 6:15 PM | MetLife Stadium, East Rutherford, NJ |
| Sunday, October 12, 2025 | Denver @ New York | 7:30 AM | Tottenham Hotspur Stadium, London, England |
| Sunday, October 12, 2025 | Arizona @ Indianapolis | 11:00 AM | Lucas Oil Stadium, Indianapolis, IN |
| Sunday, October 12, 2025 | Los Angeles @ Miami | 11:00 AM | Hard Rock Stadium, Miami Gardens, FL |
| Sunday, October 12, 2025 | Cleveland @ Pittsburgh | 11:00 AM | Acrisure Stadium, Pittsburgh, PA |
| Sunday, October 12, 2025 | San Francisco @ Tampa Bay | 11:00 AM | Raymond James Stadium, Tampa, FL |
| Sunday, October 12, 2025 | Dallas @ Carolina | 11:00 AM | Bank of America Stadium, Charlotte, NC |
| Sunday, October 12, 2025 | Seattle @ Jacksonville | 11:00 AM | EverBank Stadium, Jacksonville, FL |
| Sunday, October 12, 2025 | Los Angeles @ Baltimore | 11:00 AM | M&T Bank Stadium, Baltimore, MD |
| Sunday, October 12, 2025 | Tennessee @ Las Vegas | 2:05 PM | Allegiant Stadium, Las Vegas, NV |
| Sunday, October 12, 2025 | Cincinnati @ Green Bay | 2:25 PM | Lambeau Field, Green Bay, WI |
| Sunday, October 12, 2025 | New England @ New Orleans | 2:25 PM | Caesars Superdome, New Orleans, LA |
| Sunday, October 12, 2025 | Detroit @ Kansas City | 6:20 PM | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| Monday, October 13, 2025 | Buffalo @ Atlanta | 5:15 PM | Mercedes-Benz Stadium, Atlanta, GA |
| Monday, October 13, 2025 | Chicago @ Washington | 6:15 PM | Northwest Stadium, Landover, MD |
NFL Handicapping Leaderboard
By now, betting trends are no longer speculation—they’re patterns. Our Top Handicappers are identifying momentum shifts, exposing overhyped narratives, and showing bettors where the real value lies heading into the middle third of the season.
Our experts have carefully crafted their NFL Week 6 picks to reflect real-time insights—not guesswork. With refined models and matchup-specific breakdowns, these predictions cover every angle: against the spread, over/under totals, and money lines. Whether you’re playing conservative or going bold, there’s a strategy here for every bettor.
NFL Week 6 Picks
Check out our top-rated Week 6 NFL betting predictions for spreads, totals, and money lines. Whether you’re building your bankroll or trying to bounce back, our expert picks are your playbook for success.
Crack the Week 6 Code with Scores and Stats
It’s not just about picking winners—it’s about finding angles the public misses. Our experts combine experience, analytics, and a sixth sense for value plays to help you make the smartest bets in Week 6.
Want daily updates, hot picks, and exclusive insights? Follow us on Instagram @scoresandstats, X @scoresand_stats, and YouTube for real-time breakdowns, recaps, and betting content that goes beyond the box score.
From live NFL odds to strategic game previews, Scores and Stats is your partner in smart betting all season long. Week 6 is here—let’s make it count.
Today’s Top Value Bets Are In
Your NFL Betting Assistant
