Indiana Hoosiers vs Siena Saints Picks and Predictions December 22nd 2025

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Game Preview: Siena Saints @ Indiana Hoosiers

The Siena Saints visit the Indiana Hoosiers on Monday night in Bloomington to wrap both teams’ nonconference schedules. Early odds have Indiana favored by a healthy margin at home, with a total that sits in the mid-130s, reflecting Indiana’s willingness to launch from deep and Siena’s preference for controlled possessions. The handicap comes down to whether Indiana’s 3-point volume produces separation or whether Siena can turn this into a half-court game where every empty trip raises the value of the points.

Indiana is coming off a win over Chicago State that perfectly illustrated the ceiling and the risk of a three-heavy approach: the Hoosiers built a big halftime lead behind hot perimeter shooting, then cooled off after the break. Siena enters off a road loss at Vermont where it fell behind early and never fully recovered, despite getting enough made threes to suggest the offense isn’t broken.

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Odds and Key Information

The opening number has Indiana laying double digits, and it’s the type of spread that’s usually shaped more by pace and shot selection than by a single matchup edge. Indiana’s market profile is built around 3-point variance: when the Hoosiers hit double-digit threes, the margin can escalate quickly because the opponent is forced into a faster game than it wants to play. The flip side is that a cold second half can keep an underdog within the number even if Indiana controls most of the underlying stats.

Siena’s identity adds another layer because the Saints have consistently avoided giving up huge made-three nights. If they can run Indiana off the line without overhelping at the rim, the underdog becomes more live on the spread, especially if the game stays out of the bonus early. The other key factor is game flow after halftime. Indiana’s recent pattern suggests the first 20 minutes can be explosive, but the second half can slow if threes stop falling and the Hoosiers settle for quick attempts. From a coaching standpoint, Darian DeVries has been clear that the defense has to travel even when the shot doesn’t, which is important in a game where Indiana may be tempted to keep firing regardless of score.

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Indiana Outlook

Indiana’s offense is designed to generate volume from behind the arc, and the spacing around Lamar Wilkerson is the engine. When Wilkerson is seeing clean catch-and-shoot looks and quick pull-ups off ball screens, Indiana’s efficiency spikes because the defense has to extend, opening driving lanes and dump-offs. The encouraging sign from the Chicago State game was that Indiana showed it can still score inside and at the line even when the threes aren’t the only answer, with Reed Bailey producing without relying on perimeter attempts.

The concern is shot quality management. A high 3-point attempt count is not automatically a problem, but quick, contested threes can be. Indiana’s best games typically feature a clear sequence: paint touch, kick, extra pass, then the three. Defensively, the Hoosiers can cover a spread if they keep the opponent out of transition and rebound well enough to avoid second-chance swings. If Indiana is sharp defensively for 40 minutes, Siena won’t get enough easy points to survive long scoring droughts.

Siena Outlook

Siena’s best chance to compete is to keep Indiana from turning a normal game into a three-point avalanche. The Saints have shown they can limit opponents’ made threes, and that fits the main goal in Bloomington: make Indiana finish possessions inside the arc and force it to execute longer. Offensively, Siena needs a more stable start than it had at Vermont. Falling behind early is dangerous against an Indiana team that gains confidence through made threes and crowd momentum.

Gavin Doty gives Siena a reliable scoring reference point, but the Saints need multiple contributors to score efficiently, especially if Indiana’s defense is forcing late-clock decisions. Siena’s perimeter shooters can keep them attached if they get clean looks, but the Saints also have to prevent the game from becoming a rebound deficit that produces extra Indiana possessions. If Siena can stay competitive on the glass and avoid a turnover spike, it can make this a grind where the spread is in play deeper into the second half.

Key Matchup Table

Key FactorAdvantage
3-point attempt volume and spacingIndiana
Limiting opponent made threesSiena
Defensive consistency when shots aren’t fallingIndiana
Pace control and half-court possession valueSiena
Late-game free throw shooting and margin protectionIndiana

Betting Trends

Indiana’s most actionable trend is tied to the three-ball: the Hoosiers have consistently won when they reach double figures in made threes, and their worst nights have come when the perimeter efficiency collapses and the offense becomes too jump-shot dependent. Siena has a clear defensive tendency as well, with opponents generally not getting to a massive made-three number, which is meaningful against a team that’s comfortable attempting 40-plus threes if the game invites it.

This matchup also has a totals angle that’s easy to track: if Siena succeeds in controlling tempo and forcing longer possessions, the game leans under even if Indiana wins comfortably. If Indiana turns stops into early offense and Siena has to trade threes to keep pace, the game can run past a mid-130s total. For the cleanest market snapshot and live number movement as tip approaches, use the college basketball scores and odds board.

The Lean

Siena has the defensive profile to hang around early, but Indiana’s combination of shot volume and home-court pace pressure usually shows up over 40 minutes. The Saints can keep the spread honest if they avoid quick live-ball turnovers and rebound well enough to prevent Indiana from stacking extra possessions. Still, Indiana’s shooters generate enough attempts that even an average shooting night can create separation, and Wilkerson’s recent form raises the Hoosiers’ floor.

I lean Indiana to cover because the matchup gives them multiple paths: a hot perimeter start, a defensive-driven run, or a steady interior game that forces Siena into tougher shots. On the total, I lean slightly under because Siena’s most realistic game plan is pace control, and Indiana can still win by double digits without the game turning into a full track meet. For broader context across Monday’s slate, the league hub at NCAAB previews is the best place to compare tempo profiles.

Projected score: Indiana 76, Siena 61
Best bet: Indiana -12.5
Total lean: Under 137.5

Why You Need Expert Picks

Games like this are where the spread is more fragile than it looks. Indiana can lead wire-to-wire and still flirt with a backdoor if the second half turns into quick threes and long rebounds, or if bench-heavy minutes inflate variance. Siena, meanwhile, can play a clean, structured game and still lose by 15 if two or three Indiana shooters get loose at the same time. That’s why expert projections help: they force the handicap to be about repeatable edges, like shot quality, possession count, and rebounding margin, rather than one hot half.

If you want a reliable place to compare daily opinions and track performance, the Handicappers Leaderboard is tied to the college basketball picks page. It also helps to vet sources before following any single angle, which is where handicappers sites reviews can sharpen your process. For a broader foundation on bankroll, line movement, and matchup-based betting, keep the main expert betting guide in your rotation, and use the NCAAB teams hub to compare team profiles quickly when you’re evaluating how a mid-major style translates on the road. If you’re also following longer-range market context, the college basketball championship odds and the John Wooden Award odds pages can help you understand how perception shifts after signature performances.

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