Boston Red Sox vs Cleveland Guardians Picks and Predictions September 3th 2025

Boston Red Sox vs Cleveland Guardians September 3th 2025

The Cleveland Guardians visit the Boston Red Sox at Fenway Park. The game is set for Wednesday, September 3, 2025, at 6:45 PM. The Guardians hold a 68-69 record, standing third in the AL Central, while the Red Sox have a 78-62 record, placing them second in the AL East.

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Both teams enter the game with different streaks. The Guardians are on a three-game losing streak, while the Red Sox have won their last three games. The weather forecast predicts a warm day with a light breeze and clear skies, perfect for an evening game.

Guardians vs Red Sox Key Information

• Sport: Baseball
• Teams: Cleveland Guardians vs. Boston Red Sox
• Venue: Fenway Park in Boston, MA
• Date: Wednesday, September 3, 2025
• Betting Odds: Guardians Moneyline +121, Red Sox Moneyline -142, Guardians Runline +1.5 (-172), Red Sox Runline -1.5 (+144), Total Over 9.0 (-104), Total Under 9.0 (-118)

The Guardians Can Win If…

The Cleveland Guardians recently played against the Boston Red Sox, losing 11-7. Despite the loss, the Guardians showed power with four home runs. Jhonkensy Noel, Brayan Rocchio, and Austin Hedges each contributed a homer, displaying their ability to score runs quickly.

The Guardians have some impressive stats this season. They are ranked 10th in stolen bases with 106, showing their speed on the bases. Their pitching staff has a solid ERA of 3.99, placing them in the middle of the league, which can help keep games close.

José Ramírez is a key player for the Guardians. With a batting average of .280 and 26 home runs, he leads the team in both categories. His consistent performance can be a game-changer, providing the offense needed to secure a win against the Red Sox.

The Red Sox Can Win If…

The Boston Red Sox are coming off a strong 11-7 win against the Cleveland Guardians. They tallied 18 hits, with Ceddanne Rafaela driving in four runs and hitting a home run. Nathaniel Lowe also contributed with a home run, showing the team’s ability to produce runs from multiple players.

Boston’s batting lineup has been consistent, ranking 4th in batting average at .255 this season. They lead the league in doubles with 282, demonstrating their knack for hitting extra-base hits. Their on-base percentage is also solid at .325, placing them 5th in the league.

On the mound, Brennan Bernardino will start for the Red Sox. He has a 3.08 ERA, which is impressive and suggests he can limit opposing teams’ scoring. With a WHIP of 1.25, Bernardino shows control, and his record of 4-2 indicates he can secure wins for the team.

The Lean

The Red Sox are favored to win with a moneyline of -142. Our model projects the Red Sox to win with a score of 5-3. The Red Sox have a strong batting average and slugging percentage compared to the Guardians, which supports picking them to win straight up.

The total for the game is set at 9.0 runs. Our model projects a total score of 8 runs. Both teams have solid pitching, with the Red Sox having a slightly better earned run average. This suggests taking the under on the total of 9.0 runs.

Red Sox Chase Series Sweep with Roman Anthony’s Status in Question

The Boston Red Sox are riding momentum into Wednesday’s series finale against the Cleveland Guardians, but they may have to do it without one of their brightest young stars.

Rookie outfielder Roman Anthony left Tuesday night’s 11-7 win after appearing to tweak his side during a fourth-inning strikeout. Anthony, who was replaced by Nate Eaton in right field, was later diagnosed with left oblique tightness.

Anthony’s Impact Since Call-Up

Since being recalled from Triple-A Worcester on June 9, the 22-year-old has been a major contributor to Boston’s offense.

Roman Anthony – 2025 Season Stats (Red Sox)

With Wilyer Abreu already on the IL due to a calf strain, Boston’s outfield depth will be tested if Anthony misses time.

Boston’s Playoff Push Gaining Steam

The Red Sox (78-62) have now won three straight and moved a season-high 16 games over .500. They currently hold the second AL wild-card spot, just behind the Tampa Bay Rays.

The Cleveland Guardians, meanwhile, have lost three straight and are now four games behind the Seattle Mariners for the final wild-card berth.

Want to follow more playoff races? Track every club’s latest form on the MLB teams index or check out fresh MLB picks daily.

Wednesday’s Pitching Preview

The Guardians will turn to left-hander Joey Cantillo (3-3, 3.93 ERA), who will make his first career start against the Red Sox. He previously appeared in relief against Boston back in April.

Boston is expected to counter with a bullpen day, led by Brennan Bernardino (4-2, 3.08 ERA). The lefty pitched a clean ninth inning on Tuesday and has been solid in past appearances against Cleveland.

Wednesday Starters – Career vs Opponent

*Note: Only career relief outing vs. Red Sox

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Guardians Go to Six-Man Rotation

As Cleveland pushes for a late-season surge, manager Stephen Vogt confirmed the team will shift to a six-man rotation.

That rotation includes:

• Tanner Bibee
• Gavin Williams
• Slade Cecconi
• Logan Allen
• Parker Messick
• Joey Cantillo

What’s Next for Boston?

Cora confirmed rookie Payton Tolle will start Friday’s series opener against the Arizona Diamondbacks. Dustin May will temporarily shift to the bullpen, but will return to the rotation next week.

With Anthony’s MRI results pending, the Red Sox hope their rookie star won’t be sidelined long as they continue their wild-card hunt.