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Chicago White Sox vs Baltimore Orioles September 16th 2025
The Baltimore Orioles will take on the Chicago White Sox at Rate Field in Chicago. The Orioles have a record of 70-80 and are ranked fifth in the AL East. They are coming off a win and have gone 6-4 in their last ten games.
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The White Sox hold a record of 57-94 and are also ranked fifth, but in the AL Central. They are on a four-game losing streak, with a 4-6 record in their last ten games. The game will be played on Tuesday, September 16, 2025, at 7:40 PM. The weather is expected to be warm with a light breeze and clear skies.
Orioles vs White Sox Key Information
- Sport: Baseball
- Teams: Baltimore Orioles vs. Chicago White Sox
- Venue: Rate Field in Chicago, IL
- Date: Tuesday, September 16, 2025
- Betting Odds: Orioles Moneyline +110, White Sox Moneyline -129, Orioles Runline +1.5 (-198), White Sox Runline -1.5 (+165), Total Over 8.0 (-105), Total Under 8.0 (-115)
The Baltimore Orioles Can Win If…
The Baltimore Orioles snapped their losing streak with a 4-1 win over the White Sox thanks to Kyle Bradish’s dominant five-inning outing and Colton Cowser’s three-run homer. That win highlighted the Orioles’ ability to combine power with reliable pitching when they are at their best.
Gunnar Henderson leads the team with 81 runs scored, while Jackson Holliday has added 17 home runs. The Orioles have hit 177 home runs this season, ranking 12th in MLB. Their ability to generate quick offense with the long ball gives them the potential to seize momentum in any inning.
Dean Kremer will start with a 4.43 ERA and 1.26 WHIP. While not overpowering, he has kept Baltimore competitive in most of his outings. The Orioles’ pitching staff ranks 14th in quality starts, giving them a chance to support their lineup with solid performances. If Kremer stays healthy and limits walks, Baltimore has the tools to win again.
The Chicago White Sox Can Win If…
The Chicago White Sox will try to bounce back after falling 4-1 to Baltimore in their last outing. Tyler Gilbert impressed in a short relief stint, and the offense showed flashes from Colson Montgomery and Dominic Fletcher. For Chicago to win, their bats need to provide more consistent production against Kremer.
Shane Smith will start with a 3.78 ERA and 1.18 WHIP. He was excellent in his last outing, tossing 5 2/3 scoreless innings in a win over Tampa Bay. Since returning from injury, Smith has been sharp, going 3-0 with a 2.84 ERA in his last eight starts. If he continues to command the strike zone, he can frustrate Baltimore’s hitters and tilt the game in Chicago’s favor.
Lenyn Sosa and Colson Montgomery lead the Sox’s power push. Sosa sits atop the roster with 20 homers, while Montgomery has 18. If they can deliver against Kremer, Chicago has the offensive upside to even the series.
The Lean
According to the latest MLB odds, the White Sox are slight favorites at -129, while the Orioles are at +110. With Smith pitching well and Baltimore relying on Kremer’s return from injury, Chicago holds the narrow edge. My model projects a 5-4 White Sox victory, making the home side the recommended play.
The total is set at 8.0 runs. Baltimore enters with a .239 batting average, while Chicago sits at .234, both ranking in the lower half of MLB. My projection calls for 9 total runs, but given the recent form of both starters, the under remains the safer choice. Bettors can also review MLB Picks and the Expert Betting Guide for added insights.
Key Betting Trends
| Team | Last 10 Games | Moneyline Record | Over/Under Record |
|---|---|---|---|
| Baltimore Orioles | 4-6 | 3-7 | 5-5 |
| Chicago White Sox | 3-7 | 2-8 | 6-4 |
The Orioles have struggled on the moneyline recently but dominated the head-to-head matchup, winning 10 of their last 11 meetings with the White Sox. Chicago, meanwhile, has dropped four straight and continues to burn bettors in late September.
Players to Watch
| Player | Team | Stat Highlight |
|---|---|---|
| Gunnar Henderson | Orioles | 81 runs scored, lineup catalyst |
| Jackson Holliday | Orioles | .373 average in last 16 games |
| Colton Cowser | Orioles | 3-run HR in last game, 15 on season |
| Shane Smith | White Sox | 3-0 with 2.84 ERA last 8 starts |
| Lenyn Sosa | White Sox | 20 HR, team leader |
| Colson Montgomery | White Sox | 18 HR, growing power threat |
Cowser’s power surge and Holliday’s consistency highlight Baltimore’s young core. For Chicago, Smith’s form on the mound gives them a real chance, while Sosa and Montgomery provide the thump needed to shift the scoreboard.
Game Preview Recap
The Baltimore Orioles and Chicago White Sox continue their series as both clubs look toward next season. Baltimore’s Colton Cowser homered for the second straight game in Monday’s win, while Jackson Holliday extended his on-base streak to 16 games.
Baltimore reliever Dietrich Enns has emerged as a reliable bullpen arm since his arrival at the trade deadline, recording his second save with three perfect innings. Interim manager Tony Mansolino praised Enns’ consistency, calling him a piece for the future.
For Chicago, Smith represents a bright spot in an otherwise difficult season. His strong stretch since returning from injury has provided stability, and manager Will Venable has emphasized the importance of finishing strong despite another losing campaign.
Kremer is 2-0 with a 1.02 ERA in three career starts versus Chicago, including six strong innings in a May win. If he can overcome recent health concerns, Baltimore may extend its dominance in the matchup. But with Smith in form, the White Sox have a strong opportunity to even the series. For real-time numbers and updates, fans can track MLB Scores & Odds throughout the game.
