NFL Previews 
MLB Previews 
NBA Previews 
NHL Previews 
Soccer Previews 
Prediction 
Odds 
Last Recap 
Game Picks 
Top Handicapper 
Chicago White Sox vs San Diego Padres September 19th 2025
The San Diego Padres will take on the Chicago White Sox at Rate Field in Chicago. The Padres hold a record of 83-70 and are ranked 2nd in the NL West. They have a recent streak of one loss and a 5-5 record in their last ten games. The White Sox, with a record of 57-96, are at the bottom of the AL Central. They are currently on a six-game losing streak and have won only three of their last ten games.
Get 5,000 Expert Picks for Just $9
Today Only!
This night game is scheduled for Friday, September 19, 2025, at 7:40 PM. The weather forecast predicts warm conditions with a light breeze and overcast clouds. The Padres will start Dylan Cease on the mound, who has an ERA of 4.59. The White Sox will counter with Davis Martin, who holds an ERA of 4.01. Fans can catch the game on CHSN.
Padres vs White Sox Key Information
- Sport: Baseball
- Teams: San Diego Padres vs. Chicago White Sox
- Venue: Rate Field in Chicago, IL
- Date: Friday, September 19, 2025
- Betting Odds: Padres Moneyline -167, White Sox Moneyline +141
The San Diego Padres Can Win If…
The San Diego Padres are looking to rebound after a 6-1 loss to the Mets, but their lineup remains dangerous. Fernando Tatis Jr. went 2-for-4 in that defeat, while Luis Arraez added an RBI, proving San Diego’s ability to generate offense even against strong pitching.
The Padres’ overall consistency at the plate has kept them competitive. They rank 6th in MLB with a .252 batting average and 8th in on-base percentage at .318. Manny Machado has been on a tear, hitting 9-for-19 with three homers in his last five games, while Ramón Laureano has chipped in 24 home runs.
On the mound, Dylan Cease gets the ball. Despite his 4.59 ERA, he’s surpassed 200 strikeouts for the fifth straight season. San Diego’s staff ranks 3rd in ERA at 3.70 and leads the league with a .225 batting average against. If Cease delivers and the lineup provides run support, the Padres will be positioned for a road win.
The Chicago White Sox Can Win If…
The Chicago White Sox come into this series trying to snap a six-game losing streak. In their latest outing, Mike Tauchman launched a home run, and Edgar Quero added two hits. While the offense has been inconsistent, the power potential remains with Lenyn Sosa, who leads the team with 20 long balls.
Chicago ranks 16th in home runs with 154, showing they can go deep when needed. Chase Meidroth has also been a bright spot, riding a 13-game hitting streak while batting .422 during that stretch. If the Sox can combine power with contact hitting, they can put pressure on Cease early.
Davis Martin will take the mound with a 4.01 ERA and a WHIP of 1.28. He has shown the ability to settle in after rocky starts, allowing only two runs in his most recent outing. If Martin can limit damage against the Padres’ middle of the order, the White Sox have the pieces to stay competitive at home.
The Lean
The Padres are favored at -167 on the moneyline, while the White Sox are +141 underdogs according to the latest MLB odds. San Diego’s superior pitching depth and strong batting average against make them the more reliable play. My model projects a 5-3 Padres win, suggesting they should be the moneyline pick.
The total is set at 8.0 runs, with the over at -115 and under at -106. With Cease holding a 4.59 ERA but backed by one of the league’s strongest staffs, and the White Sox struggling to maintain offensive consistency, the under looks appealing. My model projects exactly 8 runs, making the under 8.0 runs a slight recommendation. For more analysis, see MLB Picks and the Expert Betting Guide.
Key Betting Trends
| Team | Last 10 Games | Moneyline Record | Over/Under Record |
|---|---|---|---|
| San Diego Padres | 6-4 | 6-4 | 5-5 |
| Chicago White Sox | 2-8 | 2-8 | 4-6 |
Additional betting notes:
- The Padres are 5-1 in Dylan Cease’s last six starts.
- The White Sox are 1-6 in their last seven games against NL opponents.
- The under is 7-3 in Chicago’s last 10 home games.
Players to Watch
| Player | Team | Stat Highlight |
|---|---|---|
| Dylan Cease | Padres | 200+ Ks, 4.59 ERA, first start vs. former team |
| Manny Machado | Padres | 9-for-19, 3 HR in last 5 games |
| Fernando Tatis Jr. | Padres | Multi-hit game vs Mets, key lineup anchor |
| Davis Martin | White Sox | 4.01 ERA, 1.28 WHIP, steady rotation arm |
| Lenyn Sosa | White Sox | Team HR leader with 20 |
| Chase Meidroth | White Sox | Batting .422 over 13-game hitting streak |
Game Preview Recap
The San Diego Padres enter this matchup chasing the Dodgers in the NL West while holding a firm grip on a wild-card spot. The Chicago White Sox, meanwhile, are simply trying to avoid a third straight 100-loss season.
Dylan Cease will make his first start against his former team after being traded to San Diego before the 2024 season. He has been solid down the stretch, giving the Padres a reliable arm to lean on. Davis Martin gets the nod for Chicago and will look to replicate past success against San Diego after a solid five-inning effort in his last start.
The Padres’ offense leans heavily on stars like Tatis Jr. and Machado, both of whom have been producing in September. Chicago will look to Sosa’s power and Meidroth’s hot bat to spark their offense. However, with the Padres owning one of MLB’s top pitching staffs, they appear better equipped to control the pace of play.
As the season winds down, San Diego is looking to clinch another postseason berth, while the White Sox are playing for pride. Fans tracking this matchup can follow live updates on MLB Scores & Odds and check the Teams section for deeper stats.
