Chicago White Sox vs Seattle Mariners Picks and Predictions May 19th 2025

Red-Hot Mariners Face Sinking White Sox in Chicago

After hitting their lowest point of the season last week, the Seattle Mariners rebounded with a statement sweep of the San Diego Padres—and now they’re back on the upswing. Monday night, they open a three-game set on the road against the struggling Chicago White Sox, who limp in after being swept by the Cubs.

The vibe for each team couldn’t be more different.

Mariners Bounce Back After Injury Setbacks

Seattle lost five of six at home last week, dropping series to the Blue Jays and Yankees and snapping a nine-series win streak. Even worse, they added Bryce Miller to the injured list with right elbow inflammation—joining Logan Gilbert and George Kirby, who are already shelved with arm issues.

But instead of unraveling, the Mariners responded in dominant fashion, sweeping a dangerous Padres squad and outscoring them 15–3. The pitching staff—led by fill-ins Emerson Hancock, Logan Evans, and Bryan Woo—delivered in every start.

“These guys know who they are,” said manager Dan Wilson. “There wasn’t any panic. They just went out and executed.”

Woo allowed just one run over seven innings in Sunday’s 6–1 win, building on momentum and pushing Seattle back to the top of the AL West.

To get updated odds for tonight’s matchup, visit our MLB odds page, and for picks, visit the MLB picks page.

White Sox Continue to Slide

Meanwhile in Chicago, the White Sox are enduring a nightmare stretch. They’ve now lost four straight and are 3–11 in their last 14 games. Their weekend series against the Cubs turned ugly fast—the South Siders were outscored 26–8 and never looked competitive.

Tempers flared during Sunday’s 6–2 loss when Miguel Vargas was hit by a 98 mph pitch from Brad Keller. The two exchanged words, but cooler heads prevailed.

“No one likes to get hit by 98 miles an hour,” said manager Will Venable. “Whatever happened, happened.”

The incident was more frustration than fire—a sign of a team stuck in a freefall.

Pitching Matchup: Castillo vs. Martin

Monday’s opener will feature a battle of right-handers with identical ERAs:

• Luis Castillo (3–3, 3.65 ERA, Mariners): The veteran righty has been solid but unspectacular this season. Known for his electric fastball and changeup combo, he’ll look to carve through a White Sox lineup that’s slashing just .218 at home this month.Davis Martin (2–4, 3.65 ERA, White Sox): Martin has been decent, pitching into the fifth or sixth inning regularly, but he hasn’t had much run support. Chicago is scoring just 3.1 runs per game in his starts.

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Key Stats to Know

Seattle Trends:

• Won 3 straight
• Outscored opponents 15–3 over last 3 games
• 12–6 on the road this season

Chicago Trends:

• Lost 4 straight
• Outscored 26–8 vs. Cubs
• 3–12 in last 15 games
• Team ERA in May: 5.89

Seattle is winning with depth pitching and timely offense, while Chicago continues to unravel on both sides of the ball.

Player to Watch: Bryan Woo

Woo has emerged as a breakout story for Seattle. His poise and command in Sunday’s start capped off a brilliant run from the Mariners’ makeshift rotation. If Castillo brings similar control tonight, Seattle’s bullpen—one of the best in the AL—should take it home.

“No matter who’s going out there, it’s next guy up,” Woo said. “We all want to do our job.”

Expect the Mariners’ arms to keep that energy rolling.

Betting Angles

• Mariners –1.5 Run Line: Seattle is surging, and Castillo gives them a major edge on the mound. Backing them to win by two or more has solid value.
• Under 8 Runs: Both starters have sub-4.00 ERAs, and Chicago’s cold bats may struggle again.

For deeper prop breakdowns and split analysis, check our expert betting guide.

Series Outlook

Seattle is trending in the right direction at the perfect time. Despite the injury bug, the team’s identity is intact—strong pitching, elite defense, and just enough pop. Meanwhile, the White Sox are in disarray, with questions swirling about clubhouse leadership, offensive production, and who’s stepping up next.

For more insights on rosters, matchups and lineup changes, check our full team stats page. There you’ll find:

• Batter-pitcher matchups
• Bullpen usage
• Advanced splits and live updates

If the Mariners continue to click, this could be the start of a long run—while the White Sox are left searching for answers in front of a home crowd that’s quickly losing patience.