Houston Astros vs Seattle Mariners Picks and Predictions May 23rd 2025

Mariners Await Positive Pitching News in Houston Showdown

The Seattle Mariners walked into Houston with a mission—hold their ground against the Astros and bring their pitching staff back to full strength. While the opening game of the four-game series didn’t go their way, the silver lining lies in the return of their ace and the promise of more to come.

Fans might have winced at the 9-2 loss on Thursday, but George Kirby’s long-awaited season debut was a clear sign that better days are on the horizon. Despite some early hiccups, Kirby’s presence on the mound is the spark the Mariners’ injury-riddled rotation desperately needed.

Let’s dive into where Seattle stands, who’s back, who’s still healing, and why Friday’s game could be a turning point.

The Return of George Kirby: A Step Forward Despite the Score

After missing the first 48 games of the season due to right shoulder inflammation, George Kirby finally made it back to the mound. His stats? Not jaw-dropping—but encouraging.

In just under four innings, Kirby gave up five runs on six hits, struck out four, and walked only one. Not the outing of the year, but after a long layoff, showing decent command and flashes of elite form was a win in itself.

Seattle manager Dan Wilson was optimistic:

“Our guys are getting closer and closer to being healthy, and Thursday was that first step with George.”

Kirby’s return symbolizes more than just an extra arm in the rotation—it represents the beginning of Seattle’s push toward full-strength pitching dominance.

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What’s Next for Seattle’s Rotation?

Two other key pieces of the Mariners’ rotation, Bryce Miller and Logan Gilbert, are expected to throw on Friday in simulated situations. Miller is recovering from right elbow inflammation, while Gilbert is dealing with a flexor strain.

Both injuries caused major ripples in Seattle’s rotation plans, but their imminent returns could be the boost this team needs in a competitive AL West race.

As Wilson put it, “We’re looking forward to getting those guys some work Friday.”

Stay updated with real-time stats and projections on the MLB Team Page.

Emerson Hancock Gets the Ball on Friday

With Kirby’s return complete and two other arms prepping to follow, it’s Emerson Hancock’s turn to shine.

He’ll take the mound on Friday after a solid, if unspectacular, outing against San Diego where he allowed just one run over nearly five innings. Though his 6.21 ERA doesn’t scream “ace,” Hancock has quietly put up a 2.91 ERA on the road, and the Mariners are undefeated in his away starts.

Could Friday be the moment he steps up and solidifies a long-term spot?

Check our MLB Picks Page for expert predictions ahead of Friday’s clash.

How Do the Astros Stack Up?

Facing off against Hancock will be rookie Ryan Gusto, a pitcher still trying to find his rhythm.

He’s made 11 appearances this season, with mixed results depending on his role. As a starter, his ERA climbs to 6.33, while he boasts a 0.93 ERA out of the bullpen. Clearly, he’s more comfortable coming in as a reliever, but Houston needs starters right now.

His most recent start? A rough one against the Royals: seven runs on seven hits in just over two innings. Not the kind of momentum you want when facing a team hungry for redemption like Seattle.

That said, Gusto did notch his first career win against Seattle back in April—though it was in relief. Friday’s game marks his first start against the Mariners.

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Injury Woes for Houston’s Rotation

Houston isn’t exactly enjoying smooth sailing either. Their ace Ronel Blanco just landed on the 15-day injured list, joining Spencer Arrighetti and Hayden Wesneski. The rotation is stretched thin, and manager Joe Espada isn’t sugarcoating it.

“It’s happening not only here but throughout the league… We have to work through this and fight through this.”

Espada’s right—every team deals with injuries. But for a franchise like Houston that’s used to dominating, these setbacks could leave the door wide open for Seattle.

Seattle’s Keys to Victory in the Remainder of the Series

As more arms return, Seattle’s success hinges on its starters. If Kirby, Miller, and Gilbert can all return to form quickly, the Mariners will have one of the deepest rotations in the American League.

Jump on Houston’s Weakened Pitching

With the Astros missing key starters, now is the time for Seattle’s offense to pounce. Targeting Gusto early and forcing the Astros’ bullpen into action could tip the scales.

Clean Defense and Bullpen Stability

Even with better starting pitching, Seattle needs consistency from its bullpen and solid defensive support to stay competitive. Small mistakes can quickly turn into big innings in a hostile environment like Houston’s.

FAQs

What’s the latest update on George Kirby’s injury?

Kirby returned Thursday after missing 48 games with shoulder inflammation. He gave up five runs but showed positive signs in his return.

When are Bryce Miller and Logan Gilbert expected back?

Both are expected to pitch in simulated sessions on Friday. Depending on how they feel, they could rejoin the rotation within a week.

Who is starting for the Mariners on Friday?

Emerson Hancock is set to start. He’s 1-0 with a 2.91 ERA in road games this season.

How has Ryan Gusto performed as a starter?

He’s struggled, posting a 6.33 ERA in five starts. However, he’s been solid as a reliever.

How many pitchers are the Astros missing?

Currently, three starting pitchers are out: Ronel Blanco, Spencer Arrighetti, and Hayden Wesneski.

Where can I get expert MLB picks?

Head over to the MLB Picks Page for insights and predictions.

Final Thoughts: Mariners Poised for a Bounce-Back

The Mariners may have dropped the first game, but with their pitching staff inching back to full health, this series in Houston could mark a major turning point. With the Astros facing their own injury battles, Seattle has a golden opportunity to strike back and build momentum heading into June.

Stay tuned and follow the rotation drama—because this series is about more than just a few wins. It’s about setting the tone for the rest of the season.