New York Yankees vs Chicago White Sox Picks and Predictions September 23rd 2025

The Chicago White Sox will take on the New York Yankees at Yankee Stadium. The game is scheduled for Tuesday, September 23, 2025, at 7:05 PM. The White Sox have a record of 58-98 and are on a two-game losing streak. They are ranked fifth in the AL Central.

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The Yankees hold an 88-68 record and are second in the AL East. They are on a two-game winning streak and have been strong in their last ten games, going 7-3. The starting pitchers for the game are Shane Smith for the White Sox and Luis Gil for the Yankees. The game will be broadcast on the YES channel, and the weather is expected to be warm with a light breeze under broken clouds.

White Sox vs Yankees Key Information

• Sport: Baseball
• Teams: Chicago White Sox vs. New York Yankees
• Venue: Yankee Stadium in New York, NY
• Date: Tuesday, September 23, 2025 at 7:05 PM
• Betting Odds: White Sox +204, Yankees -246

The White Sox Can Win If…

The Chicago White Sox enter this matchup following a narrow 3-2 loss to the San Diego Padres. Despite falling short, Sean Burke gave a steady performance on the mound with four innings of work and four strikeouts. Offensively, Miguel Vargas delivered an RBI, while Dominic Fletcher and Chase Meidroth chipped in with production.

Chicago’s power numbers provide a reason for optimism. They have hit 156 home runs this season, ranking 19th in the majors. Lenyn Sosa continues to be the team’s biggest threat, pacing the White Sox with 21 homers and 71 RBIs.

Shane Smith gets the start, carrying a 4.06 ERA and a 1.22 WHIP. If Smith can limit damage early and Sosa sparks the lineup, the White Sox have a legitimate chance to compete against a playoff-bound Yankees squad.

The Yankees Can Win If…

The New York Yankees head home riding momentum from a 7-1 victory over the Baltimore Orioles. Ben Rice had a breakout performance, collecting four hits including a home run and driving in five runs. On the mound, Cam Schlittler silenced Baltimore’s offense, allowing just one run across 5 1/3 innings.

The Yankees’ offensive metrics remain elite. They lead MLB in slugging percentage at .454 and home runs with 263. Their .330 on-base percentage ranks second overall, making this lineup dangerous from top to bottom.

Luis Gil will take the mound, bringing a 3.33 ERA and a 4-1 record. His ability to set the tone early will be key, as the Yankees’ powerful bats look to back him with run support. With their combination of pitching depth and hitting strength, New York enters this matchup in control.

Key Team Comparison

The Lean

The Yankees are strong favorites on the moneyline at -246, with the White Sox listed at +205. My projection calls for New York to prevail 6-3 behind their league-best slugging and home run totals. Chicago’s lack of consistency at the plate makes it difficult to trust them in this spot.

The total is set at 9.0 runs, with the model projecting exactly 9 runs scored. Given the Yankees’ offensive upside and the White Sox’s pitching vulnerabilities, the over is a reasonable lean, though bettors may want to tread carefully.

For more market updates, check the latest MLB odds.

Betting Trends

• Yankees are 19-8 in their last 27 games overall.
• White Sox are 1-8 in their last nine contests.
• The over has cashed in four of the Yankees’ last five home games.

More daily breakdowns can be found on the MLB picks page.

Yankees Still Pushing for Division Title

Although a playoff spot is nearly secured, New York still has its eyes on the AL East crown. Entering this game, the Yankees sit two games behind the Blue Jays with six left to play. Manager Aaron Boone has stressed the importance of every win, with home-field advantage in October also hanging in the balance.

Ben Rice’s recent surge has been timely. His grand slam against Baltimore capped off a breakout stretch in which he’s batting .327 over his last 14 games. With Aaron Judge sidelined, Rice’s emergence has been critical to keeping the offense steady.

White Sox Searching for Progress

For Chicago, this final week is about building toward the future. Despite a disappointing campaign, the White Sox have seen flashes of promise from younger players like Colson Montgomery and Lenyn Sosa. Montgomery recently emphasized the importance of learning through both good and bad stretches as the team looks ahead.

Shane Smith will be tasked with slowing down New York’s bats. He’s been fairly steady in recent outings, going 3-1 with a 3.66 ERA across his last seven starts. If he can replicate that form, Chicago may be able to keep this one competitive.

Probable Pitching Matchup

Explore deeper analysis in the MLB expert betting guide