New York Yankees vs Cleveland Guardians Picks and Predictions June 5th 2025

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The Cleveland Guardians will head to Yankee Stadium to take on the New York Yankees on Thursday, June 5, 2025. The game is set to start at 7:05 PM and will be broadcast on MLBN. The weather forecast predicts a very hot day with a light breeze and overcast clouds.

The Guardians, managed by Stephen Vogt, have a season record of 33-27 and are 6 games behind in the AL Central. They have a road record of 16-16. The Yankees, led by Aaron Boone, have a season record of 37-23 and perform well at home with a 19-10 record. Starting pitchers for the game are Slade Cecconi for the Guardians and Max Fried for the Yankees.

Guardians vs Yankees Key Information

  • Sport: Baseball
  • Teams: Cleveland Guardians vs. New York Yankees
  • Venue: Yankee Stadium in New York, NY
  • Date: Thursday, June 5, 2025
  • Betting Odds: Yankees MoneyLine -265, Guardians MoneyLine +217

The Guardians Can Win If…

The Cleveland Guardians are coming off a strong 4-0 win against the New York Yankees. Luis L. Ortiz delivered a solid performance, pitching 5 2/3 innings with 7 strikeouts. Key hitters like Daniel Schneemann and Angel Martínez contributed with extra-base hits and home runs.

The Guardians have shown power with 63 home runs, ranking 12th in the league. Their pitching staff has given up only 66 home runs, which also ranks 12th. This balance of power and control makes them a threat in any game.

José Ramírez leads the team with a .327 batting average and 11 home runs. His consistent performance is vital for the Guardians. With players like Carlos Santana and Kyle Manzardo also contributing, the Guardians have a lineup that can compete with any team.

The Yankees Can Win If…

The New York Yankees are coming off a 0-4 loss against the Cleveland Guardians. Despite the loss, Aaron Judge and Ben Rice each had two hits, showing their ability to get on base. Clarke Schmidt pitched well with eight strikeouts over 5 2/3 innings, keeping the game competitive.

The Yankees have strong stats this season that can lead them to victory. They are ranked 2nd in both on-base percentage (.342) and slugging percentage (.463). The team also ranks 2nd in home runs with 97, which could be a game-changer.

Max Fried will start for the Yankees, and he has been effective with a 1.92 ERA and a 7-1 record. His ability to limit runs and strikeouts will be key. With Aaron Judge leading the team in home runs and RBIs, the Yankees have the firepower to win the game.

The Lean

The Yankees are the favorite with a moneyline of -265. The Guardians are the underdog at +217. Our model projects the Yankees to win 5-3. The Yankees have a strong batting average and on-base percentage, which supports this pick.

The over/under line is set at 8.5 runs. Our model projects a total of 8 runs. Given the Yankees’ solid pitching and the Guardians’ lower slugging percentage, the under is the recommended pick.

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Max Fried Aims to Rebound as Yankees Eye Series Win vs. Guardians

Max Fried had been practically untouchable since joining the New York Yankees this season — until he met the Los Angeles Dodgers. After cruising through his first 11 starts with a microscopic ERA and pristine control, Fried got hit hard last Friday in an 8-5 loss, his first of the season.

On Thursday night, he gets a chance to reset and deliver a statement as the Yankees aim to take the rubber game of a three-game series against the Cleveland Guardians.

“We just didn’t have a great night,” manager Aaron Boone said after Wednesday’s 4-0 shutout loss. The Yankees managed just five hits and were blanked for only the second time all season. Despite the hiccup, New York is still trying to notch its eighth series win in the last nine.

Looking for sharp MLB analysis and picks? Explore the MLB Pick Page for expert breakdowns.

Fried Focused on Regaining Form After Rare Misstep

Before his tough outing in Los Angeles, Fried (7-1, 1.92 ERA) was dominating the American League. He had allowed two earned runs or fewer in every one of his starts, showing elite command and composure. But in five innings against the Dodgers, he gave up six runs on eight hits — including two homers by Shohei Ohtani and Andy Pages.

“Execution just wasn’t there,” Fried admitted. “I wasn’t hitting my spots, and when you’re facing a good team with good hitters, they’re going to make you pay for it.”

Despite the frustration, Fried remains one of the most reliable arms in the game and will be making just his second career start against the Guardians. The last came way back in 2019, when he pitched 6 1/3 strong innings for Atlanta.

Want to track pitching trends and team stats? Visit the MLB Team Page for full details.

Guardians Riding Momentum from Quick Starts and Steady Bats

Cleveland has made a habit of striking early, and Wednesday’s game was no exception. The Guardians plated three runs in the first inning — all they’d need — and used three double plays to stifle any Yankee rally.

Angel Martinez broke out of a slump with a two-run homer, while Daniel Schneemann added an RBI double in a three-hit performance. Meanwhile, Jose Ramirez extended his on-base streak to 30 games, hitting .390 during that stretch. His defense shined too, turning two of the Guardians’ three double plays.

“He’s one of the best players on the planet,” said Cleveland manager Stephen Vogt. Ramirez is now just two games shy of matching his career-best on-base streak of 32 games, set in 2018.

Also red-hot: Carlos Santana, who extended his hitting streak to 13 games while batting .413 over that span.

Check out real-time updates and lines on the MLB Odds Page.

A baseball player in a blue Seattle jersey swings a bat, with a cheering crowd blurred in the background.

FAQ: Yankees vs. Guardians Series Finale

Who’s pitching for the Yankees tonight?

Max Fried (7-1, 1.92 ERA) gets the start. He’s looking to bounce back from his first loss of the season, which came against the Dodgers.

What happened in Fried’s last outing?

He allowed six runs on eight hits in five innings. The Yankees had a 5-2 lead before the bullpen faltered and the Dodgers capitalized.

Who’s starting for the Guardians?

Slade Cecconi (1-1, 5.28 ERA), acquired from the D-backs, will make his fourth start since joining the Cleveland rotation.

How has Cecconi performed lately?

In his last outing, he allowed five runs on seven hits in just 4 1/3 innings. He also gave up a home run to Aaron Judge in a 2023 relief appearance at Yankee Stadium.

What’s at stake for both teams?

The Yankees are looking to rebound and continue their strong stretch of series wins. The Guardians, meanwhile, aim to take the season series from New York for the first time since 2021.

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Mike Williams
Mike Williams | Handicapper

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Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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