St. Louis Cardinals vs New York Yankees Picks and Predictions August 17th 2025

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The New York Yankees will take on the St. Louis Cardinals at Busch Stadium. The Yankees come into this game with a 66-57 record and are third in the AL East. They have won their last two games and are 6-4 in their last ten. Will Warren will start for the Yankees, bringing a 4.34 ERA and a 7-5 record.

The Cardinals have a 61-63 record and are fourth in the NL Central. They have lost their last four games and are 4-6 in their last ten. Miles Mikolas will be on the mound for the Cardinals. He has a 4.97 ERA and a 6-9 record. The game is set for Sunday, August 17, 2025, at 2:15 PM and will be aired on YES.

Yankees vs Cardinals Key Information

  • Sport: Baseball
  • Teams: New York Yankees vs. St. Louis Cardinals
  • Venue: Busch Stadium in St. Louis, MO
  • Date: Sunday, August 17, 2025
  • Betting Odds: Yankees Moneyline -142, Cardinals Moneyline +121, Yankees Runline -1.5 (+113), Cardinals Runline +1.5 (-134), Total Over 9.5 (+100), Total Under 9.5 (-121)

The Yankees Can Win If…

The New York Yankees are coming off a strong performance against the St. Louis Cardinals, winning 12-8. Ben Rice was a key player, driving in 7 runs with a home run and a double. Aaron Judge also contributed with a home run, while José Caballero scored 3 runs.

The Yankees lead the league in slugging percentage at .447 and home runs with 195. This power at the plate gives them an advantage. Their on-base percentage is also ranked 4th, showing they can get on base and score runs.

Pitcher Will Warren will start for the Yankees with a 7-5 record. His ERA is 4.34, and he will aim to keep the Cardinals’ hitters in check. With the Yankees’ strong hitting lineup, they have a solid chance to win the game.

The Cardinals Can Win If…

The St. Louis Cardinals are looking to bounce back after a tough 12-8 loss to the New York Yankees. In that game, the Cardinals showed their power at the plate with 12 hits and three home runs. Key performances came from Nolan Gorman, Masyn Winn, and Pedro Pagés, each hitting a home run.

Despite recent losses, the Cardinals have strong stats that can lead them to victory. They rank 5th in the league with 212 doubles, showing their ability to hit for extra bases. Their batting average of .250 ranks 8th, indicating they can consistently get on base.

Miles Mikolas is set to start for the Cardinals. He has a WHIP of 1.28, showing his ability to limit base runners. With the home crowd support, the Cardinals have the potential to turn things around and secure a win.

The Lean

The Yankees are favored with a moneyline of -142 against the Cardinals at +121. The Yankees have the top slugging percentage and lead in home runs, which gives them an edge. My model projects the Yankees to win with a score of 6-4, making them the pick for the moneyline.

The total for the game is set at 9.5 runs. The Yankees’ strong hitting and the Cardinals’ pitching struggles suggest a high-scoring game. My model projects a total of 10 runs. Therefore, the recommendation is to take the over at 9.5 (+100).

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Yankees Feel the Urgency, Seek Sweep of Cardinals in St. Louis

The New York Yankees arrived in St. Louis with urgency on their minds, knowing every game matters in the playoff chase. That urgency has translated into wins, as the Yankees took the first two games of their weekend set against the St. Louis Cardinals and will now go for a sweep on Sunday afternoon at Busch Stadium.

The presence of Yankees general manager Brian Cashman around the team has added to the sense of importance. While some might view it as added pressure, infielder Jazz Chisholm Jr. said the team already knows what’s at stake.

“I feel like we need to step it up anyway, no matter if he was here or not,” Chisholm said. “We need to win games. We need to get to the playoffs, and we need to win the World Series. That’s all our thought is right now.”

So far, New York has delivered. A 4-3 win Friday and a 12-8 slugfest Saturday have put the Yankees in position to claim their fifth win in six games and a valuable sweep on the road.

Yankees’ Playoff Push

After Saturday’s win, the Yankees hold the third and final AL wild-card slot, with a 2.5-game lead over the Cleveland Guardians. At 6.5 games behind the division-leading Toronto Blue Jays, there’s still ground to make up in the AL East.

Cashman acknowledged both optimism and urgency:

“Right now, we’re not in control of the division, so our first goal is to try to win the American League East and automatically punch the ticket that way,” Cashman said. “If not, we’ll be fighting to punch a ticket a different way. There’s a lot of time on the clock, but not enough time at the same time. There is urgency.”

The Yankees have had to navigate injuries, with Paul Goldschmidt (knee), Giancarlo Stanton (lower body soreness), and Cody Bellinger (illness) all sidelined Saturday. But the absences opened the door for Ben Rice, who exploded with seven RBIs on three hits, including a three-run homer. Rice is now 8-for-21 with two homers, four runs, and eight RBIs in his past five games, proving to be a spark in the lineup.

Cardinals’ Struggles Continue

Meanwhile, the Cardinals have dropped four straight games, falling 4.5 games back of the New York Mets in the National League wild-card race. Injuries have piled up for St. Louis as well. Nolan Arenado (shoulder strain), Brendan Donovan (foot/groin), and Willson Contreras (foot contusion) are all out, while rookie Victor Scott II exited Saturday’s game with an ankle sprain after colliding with the wall on Aaron Judge’s home run.

Despite the setbacks, Sunday starter Miles Mikolas remains confident in his team’s fight.

Pitching Matchup: Warren vs. Mikolas

Sunday’s finale will feature two right-handers trending in different directions.

Pitching Matchup (Aug. 18, 2025)ERARecordNotes
Will Warren, Yankees (RHP)4.347-5Allowed only 3 ER in last 17.2 IP; lost lone start vs. STL
Miles Mikolas, Cardinals (RHP)4.976-93 quality starts in last 4; 1-0 with 3.97 ERA vs. NYY career

Warren has been effective recently, limiting opponents to just three runs across his last three starts. However, his only career start vs. the Cardinals came last season, when he allowed four runs in four innings in a 6-5 St. Louis win.

Mikolas enters off a strong outing against Colorado, where he lasted 6 2/3 innings with two runs allowed. He has held New York in check before, going 1-0 with a 3.97 ERA in two career starts against the Yankees.

What’s at Stake

The Yankees are aiming to close out a sweep, maintain their wild-card lead, and inch closer to the Blue Jays in the AL East. For the Cardinals, it’s about halting a skid and keeping their playoff hopes alive despite a banged-up roster.

With urgency in the air for both sides, Sunday’s matchup could prove pivotal for their postseason paths.