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Boston heads into Houston for a Wednesday afternoon start at Daikin Park, with first pitch scheduled for 2:10 p.m. ET on NESN. The Red Sox are 1-4 and trying to stop a four-game slide, while the Astros have pushed to 4-2 after ripping off four straight wins. That contrast matters here. Boston still has enough lineup talent to make this interesting, but Houston is the steadier team right now, and it is showing up on both sides of the ball. The pitching matchup is Garrett Crochet against Mike Burrows, and that is what makes this game a little tricky. Crochet has been the better arm on paper and in results so far, entering at 1-0 with a 0.00 ERA. Burrows

The Angels head to Wrigley Field on Wednesday afternoon looking to build on a 2-0 win over Chicago in the last meeting. Los Angeles is 3-3 and sitting fourth in the AL West, while the Cubs are 2-3 and trying to avoid letting this homestand drift any further. This is an interesting handicap because the market still leans hard toward Chicago at home, even after the Angels just shut them out on March 31. Weather could end up shaping the game as much as the starting pitchers. A very cold afternoon, light rain, and wind blowing out at Wrigley can make these totals tricky. Sometimes that setup screams offense, but cold air can also deaden the ball enough that the

Detroit and Arizona close out this early interleague set on Wednesday afternoon at Chase Field, with first pitch scheduled for 3:40 p.m. ET. The Tigers are 2-3 after dropping a 7-5 game on Tuesday night, while the Diamondbacks have climbed to 2-3 and are trying to salvage some momentum after a slow start. Tarik Skubal gets the ball for Detroit against Zac Gallen for Arizona, and that pitching matchup is the main reason the Tigers opened as a fairly clear road favorite. This is one of those afternoon spots where the market really is asking a simple question: do you trust Skubal to be the best arm on the field by enough margin to outweigh Arizona’s home edge? I think

The Yankees head into Seattle for a late-afternoon matchup at T-Mobile Park on Wednesday, trying to bounce back after a 2-1 loss in the last meeting. New York is 3-1 and sitting second in the AL East, while Seattle is 3-2 and third in the AL West after putting together two straight wins. This game has the look of another tight one, maybe frustratingly tight, with two starters in strong early form and weather that should help the pitchers a bit more than the hitters. Cam Schlittler gets the ball for New York after a sharp first outing, and George Kirby counters for Seattle with his usual steady profile. Add in a very cold forecast with light rain and this