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Colorado heads into Toronto for a Wednesday afternoon matchup at Rogers Centre, trying to recover from another rough start to the season. The Rockies are 1-4 and sitting at the bottom of the NL West, while the Blue Jays have opened 4-1 and already look comfortable atop the AL East. Toronto took the last meeting 5-1 on March 31, and it was another reminder of how different these teams look right now in terms of lineup depth, pitching stability, and overall game control. This game starts at 1:07 p.m. ET, and the betting market is treating it like a fairly clear mismatch. Kevin Gausman gets the ball for Toronto against Kyle Freeland for Colorado, which is a big part of

Chicago heads to loanDepot Park on Wednesday afternoon for the series finale, with first pitch set for 1:10 p.m. ET. The White Sox are 1-4 and sitting at the bottom of the AL Central, while Miami is 4-1 and already setting the pace in the NL East. The Marlins took Tuesday’s meeting 9-2, so this is a quick turnaround spot where Chicago needs a much cleaner effort just to keep the game from getting away early. For bettors scanning the rest of the slate, the broader MLB previews hub gives similar matchup context across the board. The pitching matchup is the first thing that jumps out. Sandy Alcantara comes in at 1-0 with a 0.00 ERA after a strong opener,

New York and St. Louis wrap up their three-game set Wednesday afternoon at Busch Stadium, with first pitch scheduled for 1:15 p.m. ET. Both clubs are 3-2, so this is a pretty meaningful early separator even if it is still the first week. The Mets are trying to answer after getting blanked 3-0 on Tuesday, while the Cardinals come in with a little more momentum and a chance to win the series at home. Freddy Peralta goes for New York against Matthew Liberatore for St. Louis. That matchup is interesting because Peralta brings the bigger strikeout ceiling, but Liberatore has looked steadier so far and gets the friendlier setting at Busch. Light rain and a mild afternoon are in the

Tampa Bay heads to American Family Field on Wednesday afternoon trying to stop Milwaukee from fully taking control of this series. The Rays are 2-3 and sitting fourth in the AL East, while the Brewers have opened 4-1 and already look comfortable atop the NL Central. Milwaukee grabbed the last meeting 6-2 on March 31, so this is a good spot for Tampa Bay to show whether its strong early offensive numbers are real enough to travel against a first-place club. This matchup is pretty easy to like from a betting angle because it starts with two quality arms. Drew Rasmussen goes for the Rays with a 1.80 ERA, and Jacob Misiorowski takes the mound for Milwaukee with the same