Duke Blue Devils vs Arkansas Razorbacks Picks and Predictions November 27th 2025

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Duke enters Thanksgiving night at 7-0 with wins over Texas and Kansas already on the résumé. Neutral-site games have become the constant so far, and the Blue Devils embrace the environment. Cameron Boozer continues to lead the team at more than 21 points per game, and Duke leans on its length, pace and versatility to create mismatches. For updated numbers ahead of tipoff, you can track adjustments on the NCAA basketball odds page

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Arkansas arrives at 5-1 after responding to earlier close calls with a blowout of Jackson State. John Calipari has pushed his team for toughness, and the Razorbacks have shown more edge around the rim in recent outings. Meleek Thomas and Darius Acuff Jr. lead a young backcourt that plays downhill, and their ability to attack spacing actions gives Arkansas a real scoring engine.

Both teams feature freshman stars, both push tempo, and both can score in bunches. The matchup arrives at a neutral court in Chicago, where Duke coach Jon Scheyer returns to his hometown.

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Line Movement and Odds

Duke opened around −10.5, reflecting their undefeated start and elite offensive metrics. The total sits near 157.5, one of the highest of the holiday week. Early betting splits lean toward points, with some interest on Arkansas as a double-digit dog. For matchup breakdowns across the slate, the college basketball previews page helps frame comparable games.

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Matchup Breakdown

Duke wins with spacing, shot quality and intelligent size. Boozer draws doubles that open clean looks, and Patrick Ngongba II has been nearly automatic around the rim, hitting 15 of his last 16 shots. Maliq Brown and the frontcourt pair well defensively, where Duke emphasizes discipline and less reaching.

Arkansas must match Duke’s physicality on the glass and use their attacks in transition. They average 91 points per game and shoot nearly 80 percent at the free-throw line. Malique Ewin and Karter Knox give the Razorbacks interior scoring and rebounding leverage, but defensive rotations will determine whether they stay within range.

For public-vs-sharp comparison and supporting angles, the free college basketball picks page helps frame betting expectations.

Injuries and Conditions

Duke

No new major updates reported.
Full details: Duke team page

Arkansas

No new confirmed absences ahead of the matchup.
Full details: Arkansas team page

Neutral-site indoor setting, no weather impact.

Best Bets and Prediction

Arkansas has the firepower to hang around, and Duke’s offense tends to allow extended back-and-forth stretches before creating separation. Expect both teams to score efficiently, with Duke’s depth and shot creation ultimately pulling ahead late.

Projected Score: Duke 92, Arkansas 85
Best Bet: Arkansas +10.5
Secondary Lean: Over 157.5

For matchup fundamentals and betting structure, use the Bettors Handbook

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