Louisville Cardinals vs Duke Blue Devils Picks and Predictions January 6th 2026

Last Updated on

The Louisville Cardinals, ranked #20, enter 11-3 and look to extend their home dominance, while the Duke Blue Devils, ranked #6, aim to continue their winning streak in this ACC clash at KFC Yum! Center.

Line Movement and Odds

Duke opened as the favorite, with the line reflecting confidence in their offensive firepower. Current market:

  • Duke Spread: -1.5 (-106)
  • Louisville Spread: +1.5 (-119)
  • Duke MoneyLine: -118
  • Louisville MoneyLine: -106
  • Total: 161.5 (-110)

Track updates and sharper angles on College Basketball Odds.

Track Every Line Move Before It Happens

Stay Ahead of the Public, Every Time.

Matchup Breakdown

Duke Outlook

Duke averages 87.3 points per game, with Cameron Boozer, Isaiah Evans, and Cayden Boozer leading the offense. Their shooting efficiency (49.8% FG, 30th nationally) and ball movement (18.3 assists per game, 33rd nationally) highlight balance. Their 13-1 overall record underscores dominance heading into conference play.

Louisville Outlook

Louisville averages 90.4 points per game, with Ryan Conwell, Sananda Fru, and Mikel Brown Jr. (out with back injury) providing scoring depth. Their perimeter shooting (12.2 threes per game, 4th nationally) and 8-0 home record highlight offensive strength. Their 11-3 overall record underscores resilience despite recent setbacks.

Key Matchup / Path to Victory

The game hinges on Duke’s ability to maintain offensive rhythm, while Louisville must lean on Conwell and Fru to pace the offense. If Louisville controls tempo and perimeter shooting, their depth should keep the game close.

Injuries / Availability

Duke: No injury updates provided.

Louisville: Mikel Brown Jr. (back) out; Kasean Pryor (undisclosed) doubtful.

Environment

KFC Yum! Center provides Louisville with a strong home-court edge, where they are 8-0 this season. Duke’s balanced offense highlights their ability to compete in Louisville.

Go Inside the Handicappers’ Playbook

All in one spot. Real-time line moves, sharp reads, and verified edges.

Best Bets and Prediction

Projected Final Score: Louisville 88, Duke 85

  • Louisville +1.5 → Best Bet. Their offensive pace and home-court strength make them a strong cover candidate.
  • Over 161.5 → Total play. Both teams’ scoring averages point toward a combined score above the line.

Louisville’s depth and perimeter shooting should dictate the game, while Duke’s offense keeps the spread in play. Expect a competitive contest trending over the total.

Handicappers and Service Plays

Yesterday
Sas Insider
$108
2. Gino De Luca
$100
3. David MacGyver
$-26
4. Pro Picks – Andrew
$-110
This Week
Sports Hub – FREE PICKS
$1,914
2. Sas Insider
$1,713
3. Dan Jones
$958
4. Sean Murphy
$604
5. Jimmy Boyd
$600
This Month
Coach Rick
$1,535
2. Sports Hub – FREE PICKS
$1,417
3. Logan Wilson
$1,337
4. Bobby Conn
$1,250
5. Wise Guy Plays
$1,201