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DePaul vs UConn Picks and Predictions – Saturday January 10, 2026
UConn keeps finding ways to win even when the script flips. The Huskies just dug out of a 13-point hole, survived an overtime track meet with Providence, and extended their winning streak to 11. That kind of response matters for bettors because it shows you the floor is high even on a night when the defense is not perfect.
DePaul comes in with a different kind of momentum. The Blue Demons have won two straight and they’re buying into defense, which is the only way an underdog can make a Big East road game uncomfortable. They’ve already seen UConn once this season and lost by 18. The rematch question is whether DePaul can keep UConn out of rhythm long enough to stay inside a big number.
DePaul vs UConn Odds
These are the current betting lines, and bettors should keep monitoring updated college basketball odds as books adjust to late injury news and public action on ranked favorites.
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| DePaul | +950 | +16.5 (-110) | O 150.5 (-110) |
| UConn | -1800 | -16.5 (-110) | U 150.5 (-110) |
DePaul Betting Form
DePaul’s recent uptick is coming from defense and game control. When they’re locked in, they can shrink driving lanes and force opponents into late-clock possessions. That matters a lot here because UConn is at its best when it’s flowing into early offense and generating open threes or paint touches before your help can get set.
The betting challenge with DePaul is consistent scoring. They have multiple contributors, but their offensive nights can swing, and if you go cold in Hartford, the game can get away quickly. For the underdog to cover a number like this, DePaul has to avoid long empty stretches and needs to at least hold serve on the glass so UConn doesn’t stack second-chance points. For team context and trends, use DePaul stats and results.
UConn Betting Form
UConn’s profile is why the market hangs big spreads. They have multiple scoring sources, they can punish you inside or outside, and they don’t fall apart when the game gets uncomfortable. The Providence win is a good example: the defense wasn’t sharp for long stretches, but the shot-making and late-game execution kept them alive until the talent edge took over.
From a betting standpoint, the question is not whether UConn can win. It’s whether they can win by margin against a DePaul team that is leaning into defense and wants a lower-variance game. UConn is usually in the best position to cover when it defends early, rebounds, and avoids the turnovers that create easy points for the dog. For more on recent form, use UConn schedule and stats.
DePaul vs UConn Matchup Breakdown
The first meeting is the obvious reference point. DePaul had UConn slightly uncomfortable early, then UConn’s depth and shot quality separated the game. That separation usually comes from two places: rebounding and spacing. When UConn is getting clean threes and finishing possessions with defensive boards, it becomes very hard for an underdog to hang around because every empty trip turns into a run the other way.
DePaul’s best chance to compete is to turn this into a half-court possession game. That means fewer live-ball turnovers, fewer transition looks for UConn, and a defensive plan that forces the Huskies into contested twos instead of rhythm threes. If DePaul can do that, they can make the spread playable.
The total sits in a range where tempo matters. If UConn gets out and runs, 150.5 is not a scary number. If DePaul successfully slows the game and limits free throws, the under becomes live, and it also supports the underdog spread. This is also a game where late fouling can flip the total, so bettors need to be aware of how end-game variance can change a strong under position. The Expert Betting Guide is a good reference point for those late-game scenarios.
DePaul vs UConn Predictions and Best Bets
I lean DePaul +16.5.
UConn is the better team and can absolutely win by 20 if they’re sharp. But DePaul’s defensive buy-in gives them a realistic path to keep this closer than the first meeting, especially if they can control pace and make UConn score over a set defense. The Providence game also shows UConn can get loose defensively, and that’s where a big spread becomes harder to cover because the favorite trades buckets instead of building stops.
For UConn to cover cleanly, they probably need to win the rebounding margin comfortably and generate enough transition points to create separation. If DePaul limits second chances and keeps the game in the half court, the underdog number stays alive deep into the second half.
The total lean for me would be under if you believe DePaul dictates tempo, but my stronger angle is the points because it benefits from both a slow game and a competitive game script.
Best Bet: DePaul +16.5
NCAAB Picks and Handicappers on ScoresAndStats
If you’re building a Saturday card, start with college basketball picks and compare how the market is moving across the slate. For more matchup breakdowns in this format, the NCAAB previews hub is the cleanest way to stay organized.
If you prefer tracking performance over narratives, check the best handicappers and the leaderboard before you follow any angle too aggressively. For premium access to additional plays, you can also buy picks.
For research and navigation, the NCAAB teams hub helps when you’re scanning form and opponent profiles, while the ScoresAndStats blog is useful for broader betting angles. If you’re evaluating where to place action, the sportsbook reviews and handicappers sites reviews can help you compare options.
