Arizona Cardinals vs. San Francisco 49ers Preview and Predictions 09-13-2020

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The San Francisco 49ers begin defense of their 2019 division and conference titles Sunday afternoon when they host the NFC West-rival Arizona Cardinals at fan-less Levi's Stadium in Santa Clara, Calif., in the season opener.

The 49ers swept the Cardinals 28-25 on the road and 36-26 at home last season en route to a 13-3 record in the NFC West and an eventual trip to the Super Bowl, where they were beaten 31-20 by the Kansas City Chiefs.

The Cardinals finished last in the NFC West a year ago, going 5-10-1 in Kliff Kingsbury's first season as head coach.

The 49ers return 18 of 22 starters from the NFC championship team and used first-round picks to help fill the holes created by two of the departures.

After trading defensive standout DeForest Buckner to the Indianapolis Colts for a first-round pick, the 49ers selected a potential replacement in defensive tackle Javon Kinlaw.

Later in the first round, the 49ers moved up to take wideout Brandon Aiyuk, who they hope will help make up for the free-agent loss of Emmanuel Sanders.

The club also moved quickly to replace retired left tackle Joe Staley, acquiring Trent Williams from the Washington Football Team.

Quarterback Jimmy Garoppolo returns with almost all his offensive weapons, including standout tight end George Kittle, whose 1,053 receiving yards in 2019 ranked third in the NFL among tight ends.

49ers coach Kyle Shanahan noted this week that opening against Arizona means more than had his team been scheduled for a non-division opponent.

"Usually the team who wins the most games in our division makes the playoffs," he said. "If you don't do well in your division, very rarely do you find a way to make playoffs every year. I guess I could say, maybe, this year might be bigger."

The Cardinals, meanwhile, were much more active in reshaping their roster in the offseason, focusing on a defense that allowed 402.0 yards per game, the most in the NFL.

Arizona used the No. 8 overall pick of the draft on sideline-to-sideline linebacker Isaiah Simmons and plucked 9 1/2-sack defensive tackle Jordan Phillips from Buffalo as a free agent. A pass defense that served up 281.9 yards per game last year (second-most in the NFL) gets star cornerback Patrick Peterson for a whole season after he missed six games a year ago on suspension and proven import Dre Kirkpatrick.

The Cardinals' biggest offseason splash came on the offensive side of the ball when they acquired star wideout DeAndre Hopkins from Houston.

Hopkins gives second-year quarterback Kyler Murray a primary target while also creating more space for fellow wideouts Christian Kirk and Larry Fitzgerald, as well as running back Kenyan Drake.

Kingsbury wasn't talking 49ers or playoffs leading up to Sunday's opener. Rather, he's focused on improvement.

"We just want to take a step forward," he said during the preseason. "We felt like we made some progress at the back end of last year as a team, even in our practice processes and how we did things. We're hoping to build off that this year and put a better product out there.

The Cardinals enter the opener in good shape health-wise, with tight end Maxx Williams (ankle) the only question mark among the starters.

The 49ers, meanwhile, welcomed back middle linebacker Fred Warner this week from a coronavirus-related absence. Their big concern in Week 1 is at wideout, with the status of Aiyuk (hamstring) and Deebo Samuel (foot) very much up in the air. Neither practiced Wednesday.

Center Ben Garland (ankle) was limited in practice Wednesday.

--Field Level Media

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Levi's Stadium
Santa Clara, California, USA.
Capacity: 68,500

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Last Injuries

San Francisco 49ers

  • D.J. Reed

    Ques Sun | I-R

    Reed Jr. has a torn pectoral, and the team has entered him on the Injured Reserve/Non-Football Injury list as a result. His three-week window in order for the team to activate him has begun.

  • Jeff Wilson Jr.

    Ques Sun | questionable

    Wilson Jr. did not play the last game due to a calf injury, and it is unknown if he will suit up Sunday versus the Patriots.

  • Dontae Johnson

    Ques Sun | questionable

    Johnson has sat out the previous two games with a groin injury, and it remains to be seen if he will be available Sunday versus the Patriots.

  • Dante Pettis

    Ques Sun | questionable

    Pettis was absent from the last two games with a knee injury, and it has yet to be established if he will draw back into the lineup Sunday versus the Patriots.

  • Raheem Mostert

    Out indefinitely | out

    Mostert sustained a left high-ankle sprain, and he will miss an undetermined length of time.

  • Jaquiski Tartt

    Ques Sun | questionable

    Tartt was forced from the last game with a groin injury, and it is unclear if he will be active against the Patriots on Sunday.

  • Trent Williams

    Ques Sun | questionable

    Williams was lifted from the previous contest with an ankle injury, and it is undetermined if he will face the Patriots on Sunday.

  • Kwon Alexander

    Ques Sun | questionable

    Alexander missed last game due to a high-ankle sprain, and it is undetermined if he will be active Sunday against the Patriots.

Arizona Cardinals

  • J.R. Sweezy

    Out indefinitely | I-R

    Sweezy has been moved to the injured reserve list with an elbow injury, and he will miss an undetermined length of time.

  • Jalen Thompson

    Ques Sun | I-R

    Thompson has been designated for the Injured Reserve/Designated for Return list. due to an ankle injury. It is unknown if he will be activated in time for Sunday's tilt versus the Seahawks.

  • Rashard Lawrence

    Out indefinitely | I-R

    Lawrence has been shifted to the injured reserve list with a calf injury, and he will miss an undetermined length of time.

  • Kylie Fitts

    Ques Sun | questionable

    Fitts sat out last game with a hamstring injury, and it is unclear if he will suit up Sunday versus the Seahawks.

  • Chandler Jones

    I-R | I-R

    Jones has landed on the injured reserve list due to a torn biceps.

  • Devon Kennard

    Ques Mon | questionable

    Kennard has been held out of the previous two games with a calf injury, and it is unknown if he will play against the Cowboys on Monday.

  • Dennis Gardeck

    Ques Mon | questionable

    Gardeck is dealing with a foot injury, and it has yet to be established if he will face the Cowboys on Monday.

  • D.J. Humphries

    Ques Mon | questionable

    Humphries is bothered by a back issue, and it is undetermined if he will take part in Monday's matchup against the Cowboys.