Arizona Cardinals vs. San Francisco 49ers Preview and Predictions 11-17-2019

The San Francisco 49ers look to rebound from their first loss of the season when they host the Arizona Cardinals on Sunday. San Francisco was the last remaining unbeaten team in the NFL before it fell 27-24 in overtime to the Seattle Seahawks on Monday night.

Advice: Do you want to bet on NFL? Check our BetOnline Sportbook review

The 49ers hold a half-game lead over the Seahawks in the NFC West and some of the veteran players referred to the setback as one that comes with benefits. "You learn more in a loss than you do in a win most times," cornerback Richard Sherman said at a press conference. "So I guess that's the silver lining. You always learn more from a loss. I'm sure guys will take that and take the lessons that they need from that. We had a chance to win, and we didn't." Arizona has dropped three straight games and is far away from the division lead in its first season with Kyler Murray at quarterback but progress is being made. "We're just scratching the surface right now," wideout Christian Kirk told reporters. "It gives us a lot of confidence making the strides we are making. Each week we continue to ascend and it's kind of comforting to feel like we will keep growing for years to come."

TV: 4:05 p.m. ET, FOX. LINE: 49ers -10.5 O/U: 45

ABOUT THE CARDINALS (3-6-1): Murray has been efficient with 12 touchdowns against five interceptions and has passed for 2,553 yards and rushed for a club-high 351 and two scores. Veteran wideout Larry Fitzgerald leads the team with 50 receptions for 556 yards despite slowing down while second-year pro Kirk is on the rise after catching six passes for career-highs of 138 yards and three touchdowns in last week's loss to the Tampa Bay Buccaneers. The defense ranks 27th in scoring defense (28.1 points per game) and 31st in total defense (412.5 yards per game) but star pass rusher Chandler Jones is tied for the NFL lead with 11.5 sacks - his fifth straight season of 10 or more.

ABOUT THE 49ERS (8-1): Quarterback Jimmy Garoppolo has been solid while throwing for 2,054 yards, 14 touchdowns and eight interceptions but some of his targets are ailing. Star tight end George Kittle (46 receptions, 541 yards) could miss his second straight game with knee and ankle injuries while wideout Emmanuel Sanders (13 for 161, two TDs in three games with the team) will be a game-time decision after suffering a rib injury during Monday's loss. Defensive ends Arik Armstead and Nick Bosa are creating havoc with seven sacks apiece for a stingy unit that ranks second in sacks (35), scoring defense (14.3) and total defense (251.6).


1. Garoppolo passed for 317 yards and four touchdowns as the 49ers notched a 28-25 road victory over the Cardinals on Oct. 31 to end an eight-game losing streak in the series.

2. Arizona RB Kenyan Drake had 162 scrimmage yards (110 rushing, 52 receiving) in his team debut against San Francisco on Halloween night.

3. San Francisco DE Ronald Blair tore the ACL in his right knee against Seattle and was placed on injured reserve, and the club signed veteran DE Damontre Moore to fill the roster spot.


Free Daily Lock Pick: NBA: Miami vs. Milwaukee - August 6th - (100% Confidence Release)

News Breaking News

News Recaps

Key Players to Watch


Levi's Stadium
Santa Clara, California, USA.
Capacity: 68,500

Buy Tickets

no tickets found.

Last Injuries

San Francisco 49ers

  • Richie James Jr.

    Out indefinitely | I-R

    James Jr. is on the active Non-Football Injury list due to a broken wrist, and it is uncertain how much time he will need to heal.

  • Travis Benjamin

    I-R | I-R

    Benjamin has decided to sit out the entire 2020 season due to a personal reason. He has been designated for the Injured Reserve/Opt-Out list.

  • Weston Richburg

    Out indefinitely | I-R

    Richburg has been placed on the active PUP list as he is rehabbing a torn patellar tendon, and there is no timetable for return.

  • Jullian Taylor

    Out indefinitely | I-R

    Taylor will spend an unclear length of time on the active PUP list while healing from a previous torn ACL.

  • D.J. Reed Jr.

    I-R | I-R

    Reed Jr. has a torn pectoral, and the team put him to the active Non-Football Injury list as a result. He is expected to miss the entire season.

  • Jeff Wilson Jr.

    Out indefinitely | I-R

    Wilson Jr. has been shifted to the Injured Resserve/COVID-19 list, and it is uncertain when it will be safe for him to get back on the field.

  • Shawn Poindexter

    Out indefinitely | I-R

    Poindexter has been designated for the active PUP list with a knee injury. His return to the field has yet to be announced.

  • Kentavius Street

    Out indefinitely | I-R

    Street has hit the active PUP list with an injury to his knee. The severity of the ailment is not known.

Arizona Cardinals

  • Marcus Gilbert

    I-R | I-R

    Gilbert has been placed on the Injured Reserve/Opt-Out list and after deciding to sit out the duration of the 2020 season.

  • Maxx Williams

    Out indefinitely | I-R

    Williams is on the active Non-Football Illness list as he isn't feeling well. There is no timetable for return.