Arizona vs Iowa State Week 5 Odds, Picks & Preview

Iowa State Cyclones vs Arizona Wildcats September 27th 2025

The Arizona Wildcats are set to visit the Iowa State Cyclones in Week 5 of the 2025 regular season. This game will take place at Jack Trice Stadium in Ames, Iowa, on Saturday, September 27, 2025. Fans can catch the action live on ESPN at 7:00 PM.

Arizona enters the game with a perfect 3-0 record, having won all their games at home. However, this will be their first road game of the season. On the other hand, Iowa State holds a 4-0 record, including a strong 3-0 performance at home. Both teams are part of the Big 12 Conference, and this game will be crucial in the conference standings.

Arizona vs Iowa State CFB Key Information

Sport: College Football
Teams: Arizona Wildcats vs. Iowa State Cyclones
Venue: Jack Trice Stadium, Ames, IA
Date: Saturday, September 27, 2025
Betting Odds: Arizona Moneyline +185, Iowa State Moneyline -225, Arizona Spread +5.5 (-109), Iowa State Spread -5.5 (-111), Total Over 49.5 (-109), Total Under 49.5 (-112)

Arizona vs Iowa State Week 5 Betting Preview

The Arizona Wildcats travel to Ames to face the Iowa State Cyclones Saturday night. Both enter undefeated: Arizona 3–0, Iowa State 4–0 (1–0 Big 12). The Cyclones have won three tight games already this season and are battle-tested at home.

Arizona is riding a defense that has allowed just 26 points total this season. They limited Kansas State to 8 first downs and 88 passing yards in a 23–17 win. QB Noah Fifita has been efficient: 712 passing yards, 6 touchdowns, no interceptions. RB Ismail Mahdi leads their ground game with 263 yards.

On Iowa State’s side, QB Rocco Becht has tossed for 860 yards, 7 TDs and just 1 interception. Carson Hansen and Abu Sama III spearhead a balanced rushing attack. Iowa State’s defense allows only 14.3 points per game — and just 10 per game at home.

Kicker Kyle Konrardy will miss this game due to injury, handing duties to freshman Chase Smith, adding uncertainty in scoring situations.

Line Movement and Odds

Spread / total: Iowa State opened –6.5 (–115) and that remains the line. The over/under is 48.5.
Moneyline: Iowa State ~ –245, Arizona +195.
Sharp vs public money: Public backing is toward Iowa State. Some value whispers appear on Arizona +6.5.
Trends: Arizona is 1–4 ATS in its last 5 road games and 5–10 ATS over its past 15.

Matchup Breakdown

Arizona Wildcats
Their defense is a strength, ranking in the top 10 nationally in interceptions and sacks. Their pass defense has kept opponents under 100 passing yards in recent games. The rushing game gives them balance, though their offensive line depth is a concern.

Iowa State Cyclones
The Cyclones lean on Becht and play with tempo. Their run game opens up play-action opportunities. Defensively, they excel in pressure and forcing errors. Losing their kicker hurts in tight games.

Key battle
Arizona’s front seven against Iowa State’s blocking schemes. If Arizona pressures Becht and holds the line in the run game, they can stay in this. If Iowa State controls the trenches, Arizona might struggle to keep up.

Injuries and Conditions

Arizona Wildcats

OL Chubba Maae: questionable
RB Kedrick Reescano: questionable
TE Tyler Powell: out for season

Iowa State Cyclones

K Kyle Konrardy: out (seasoned kicker)
DL Tamatoa McDonough: questionable

Weather in Ames: clear conditions expected.

Best Bets and Prediction

Projected score: Iowa State 27, Arizona 24 (51 total)

Best bet: Arizona +6.5
Secondary lean: Over 48.5

Arizona’s defense gives them a fighting chance, especially if they can disrupt the Cyclones’ rhythm. Expect a close, high-leverage finish.

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Iowa State Cyclones vs Arizona Wildcats Picks and Predictions September 27th 2025