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Louisville vs Kentucky Week 14 Betting Preview
Louisville enters the rivalry game banged up and on a three game slide. Kentucky arrives at 5-6 and needs a win for bowl eligibility. The Cardinals are fighting to get healthy, especially at quarterback and running back. The Wildcats are fighting to extend their season. You can follow the updated board on our NCAA odds page.
Louisville coach Jeff Brohm confirmed that star receiver Chris Bell, one of the most productive wideouts in the country with 917 yards, will miss this matchup. Louisville also played last week without quarterback Miller Moss, top backs Isaac Brown and Keyjuan Brown, and lost Caullin Lacy midgame. Brohm said he may not know availability until late in the week.
Kentucky had momentum until last week’s 45-17 loss at Vanderbilt snapped a three game win streak. Redshirt freshman Cutter Boley threw for 280 yards and two scores. His first career start came against Louisville last year in a 41-14 loss. He has improved since and now leads an offense with more vertical confidence.
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Line Movement and Odds
Louisville opened as a short home favorite, sitting around -3. Early action pushed it toward -2.5, with both sharp and public interest split given injury uncertainty. Totals dropped quickly from an opener near 52 down toward the high 40s.
Current board:
• Spread: Louisville -2.5
• Moneyline: Louisville -148, Kentucky +122
• Total: 49.5
The market is waiting for confirmation on Moss and the Louisville backfield.
Matchup Breakdown
Louisville can win if Moss returns and stabilizes the passing structure. Without him, the Cardinals lean on short game concepts and scripted throws. Their defense must create pressure early, especially with depth concerns on offense. Louisville has struggled in run efficiency over the last month, and Kentucky will test that weakness.
Kentucky needs Boley to stay clean and find intermediate windows. When the Wildcats avoid turnovers, they can move the ball consistently. Louisville’s secondary has shown cracks during this losing streak, especially when the pass rush does not land. If Kentucky runs efficiently on early downs and Boley maintains rhythm, they can control possession.
This matchup tightens because Louisville’s offense may lack its usual explosiveness. Kentucky’s defense has been vulnerable against the pass, but the Wildcats bring steadier effort and better health into this game.
Injuries and Conditions
Louisville injury notes
• Chris Bell, out, leg
• Miller Moss, questionable
• Isaac Brown, questionable
• Keyjuan Brown, questionable
• Caullin Lacy, questionable
Full availability on the Louisville injury report.
Kentucky injury notes
• (No major confirmed absences reported, monitor late week updates)
See full details on the Kentucky injury report.
Weather
Calm conditions, light wind, mid 50s. No expected impact on totals.
Best Bets and Prediction
This game leans on injury clarity. Louisville has the higher ceiling, but Kentucky has better stability entering the matchup. The Wildcats have played their best football down the stretch, and Boley is gaining confidence.
Projected Score: Kentucky 27, Louisville 23
Best Bet: Kentucky +2.5
Secondary Lean: Under 49.5
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