Oklahoma Sooners vs Michigan Wolverines Picks and Predictions September 6th 2025

Michigan vs. Oklahoma: Rare Blueblood Clash Highlights College Football Weekend

Historic Meeting Between Storied Programs

Michigan and Oklahoma are two of the most successful programs in college football history, each ranking among the top five all-time in winning percentage. Despite their tradition-rich legacies, the schools have rarely faced each other. Saturday marks just the second-ever meeting between the Wolverines and Sooners and the first to be played on either school’s campus.

Fans looking for full previews and updates across college football can visit the NCAAF previews section at ScoresAndStats.

Michigan’s Freshman Quarterback Faces First Road Test

The No. 15 Wolverines opened their season with a 34-17 win over New Mexico. Running back Justice Haynes carried the offense, rushing for 159 yards and three touchdowns. However, much of the attention now turns to freshman quarterback Bryce Underwood, who will be making his first road start in Norman.

Michigan coach Sherrone Moore emphasized preparation for the noise and atmosphere but noted that execution and focus remain the priority. Adding to the challenge, linebacker Jaishawn Barham will miss the first half after a targeting penalty upheld on appeal.

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Oklahoma Seeks Offensive Balance

The No. 18 Sooners dominated Illinois State in their opener, winning 35-3 behind quarterback John Mateer’s 393 passing yards and three touchdowns. Mateer, who transferred from Washington State along with offensive coordinator Ben Arbuckle, has quickly given Oklahoma a veteran presence under center.

Health along the offensive line could be pivotal, with freshman standout Michael Fasusi and transfer Derek Simmons both listed as co-starters after missing the opener. The Sooners also expect more from Cal transfer running back Jaydn Ott, who is working back from injury and is projected to take on a bigger role.

Find the latest NCAAF odds to track how bettors view the Sooners’ chances at home.

Coaching Connections Add Intrigue

Sherrone Moore, now leading Michigan, played on Oklahoma’s offensive line in 2006-07. While he downplays the personal angle, his return to Norman creates an added storyline. Oklahoma coach Brent Venables, who coached Moore as defensive coordinator, praised his former player’s competitiveness and leadership.

These connections add another layer to what is already a marquee nonconference showdown between two ranked programs.

For expert insight before kickoff, review the latest college football picks and selections from top handicappers.

What to Watch For

Several key factors stand out ahead of this matchup:

• Michigan’s ability to manage the atmosphere with a freshman quarterback making his first road start.
• The impact of missing linebacker Jaishawn Barham for the first half.
• Oklahoma’s effort to establish balance with Mateer’s passing and a stronger run game from Jaydn Ott.
• Health and performance along the Sooners’ offensive line.

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