Oregon Ducks vs Usc Trojans Picks and Predictions November 22nd 2025

Game Preview USC Trojans @ Oregon Ducks

The Oregon Ducks enter Week 13 ranked No. 7 and remain squarely in the College Football Playoff conversation. At 9-1 overall and 6-1 in Big Ten play, Oregon continues to strengthen its postseason positioning. On the opposite sideline, the USC Trojans also sit at 8-2 and 6-1, clinging tightly to playoff hopes of their own. Saturday’s matchup at Autzen Stadium carries direct implications for conference standings, playoff seeding, and tiebreaker scenarios.

Oregon’s 42-13 win over Minnesota showcased their balance and physical dominance. Tight end Kenyon Sadiq returned and immediately contributed as the team’s leader in receptions and touchdown catches. The Ducks hope to also regain wide receiver Dakorien Moore, the team’s leader in receiving yards, after missing two games.

Oregon’s ground game remains one of the nation’s most efficient units. Jordon Davison has scored five touchdowns in his last four games and 12 total on the season, while Noah Whittington averages an elite 8.2 yards per carry. The Ducks complement this firepower with a defense allowing only 13.7 points per game.

USC counters with the Big Ten’s top passing offense. Jayden Maiava leads the conference in passing yards, averaging 286.8 per game. Makai Lemon leads the Big Ten in both receiving yards per game and receptions per game. With USC facing Oregon’s tough run defense, the Trojans’ path to success likely leans heavily on Maiava’s ability to attack downfield and maintain drive momentum.

This matchup includes multiple layers of interest for bettors. Market comparisons through NCAAF odds and projections on NCAAF picks support deeper evaluation, while strategic resources such as alternate total points, how betting odds work, and winning margin meaning help frame derivative options.

Odds and Key Information

USC Moneyline: +297
Oregon Moneyline: -384
Spread: Oregon -10.0 / USC +10.0
Total: 59.5
Venue: Autzen Stadium, Eugene, OR
Kickoff: Saturday, November 22, 3:30 p.m. ET
Broadcast: CBS

Secondary angles can be analyzed using teaser betting, parlay structures, and prop betting concepts.

USC Outlook

The Trojans enter with momentum after a 26-21 win over Iowa, a game in which Maiava threw for 254 yards and the defense generated a key interception. USC’s passing metrics remain elite. Their 2,981 passing yards rank 13th nationally, and Lemon’s 1,090 receiving yards place him among the most productive receivers in the country.

USC’s ability to generate pressure is also notable. With 24 sacks and 10 interceptions, the Trojans’ defense has created high-leverage opportunities in key situations. To stay competitive with Oregon, USC must protect the football, sustain tempo through the air, and leverage chunk plays in space.

However, defensive volatility remains a concern. While USC has allowed no more than three second-half points in its last three games, those opponents—Nebraska, Northwestern, and Iowa—lack the offensive potency of Oregon.

Understanding USC’s risk profile is supported by models and tools found in guides such as hedge betting, 1×2 meaning, and how live betting works.

USC Injury Report

Eli Sanders (RB) – Out
Anthony Beavers Jr. (LB) – Questionable
Prophet Brown (CB) – Questionable
J’Onre Reed (OL) – Questionable
Jamaal Jarrett (DT) – Questionable
Caden Chittenden (K) – Questionable
Zacharyus Williams (WR) – Questionable
Chasen Johnson (CB) – Out
Waymond Jordan (RB) – Questionable
Harry Dalton III (RB) – Questionable

Oregon Outlook

Oregon’s 42-13 dismantling of Minnesota revealed a complete performance. Dante Moore threw for 331 yards, and the Ducks held Minnesota to just 62 rushing yards. Oregon’s offense ranks ninth in rushing yards and tenth in total points scored, while the defense ranks among the most disciplined units in the nation.

The Ducks’ offensive core continues to expand. With Sadiq and potentially Moore returning, Oregon gains additional dimensions in route creativity and spacing. Their rushing attack remains the centerpiece, led by Davison and Whittington, whose combined workload offers both explosiveness and balance.

Defensively, Oregon’s 9 interceptions and ability to eliminate early-down inefficiency establishes strong leverage against pass-heavy opponents. USC’s pass volume provides opportunities for Oregon to create turnovers, disrupt rhythm, and limit yards after catch.

For deeper analysis, bettors can reference tools such as handicap betting, sports betting for beginners, and the broader NFL expert betting guide.

Oregon Injury Report

Gary Bryant Jr. – Questionable
Kyler Kasper – Out
Makhi Hughes – Out
Evan Stewart – Out
Bryce Boulton – Out
Jayden Limar – Questionable
Gernorris Wilson – Questionable
Sione Laulea – Questionable
Dillon Gresham – Questionable
Da’Jaun Riggs – Questionable
Tionne Gray – Questionable
Jack Ressler – Questionable

Key Matchup Table

Category	Edge
Passing Production	USC
Rushing Efficiency	Oregon
Defensive Pressure	Oregon
Explosive Plays	USC
Turnover Creation	Oregon
Home Field Impact	Oregon

Betting Trends

Oregon is 28-2 straight up in its last 30 games.
Oregon is 21-1 straight up in its last 22 home games.
Oregon is 25-3 straight up in games with totals of 50 or more.

USC is 10-1 straight up as a favorite in its last 11 games.
USC is 4-1 ATS as an underdog in its last five.
USC is 7-2 ATS after a loss in its last nine contests.

Supporting resources such as futures betting, how betting odds work, and teaser betting concepts can assist in evaluating derivative markets.

Predictions

Oregon’s combination of offensive potency, trench strength, and home-field advantage establishes them as a strong favorite. USC’s aerial attack gives the Trojans a path to remain competitive, but Oregon’s defensive discipline and efficiency on early downs shape the projected margin.

Projected Score: Oregon 35, USC 24
Spread Pick: Oregon -10
Total Lean: Over 59.5

Why You Need Expert Picks

Late-season matchups between top-15 teams require layered analysis of injury updates, pace, and matchup leverage. Bettors can enhance decision-making through models featured on the Handicappers Leaderboard. Additional tools such as alternate total points, sports betting strategies, and prop bet fundamentals provide clarity when navigating competitive matchups with high totals.