Purdue Boilermakers vs Indiana Hoosiers Picks and Predictions November 28th 2025

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Indiana arrives at 11-0, ranked second, and locked in on a simple goal. Beat Purdue, keep the Big Ten Championship berth. Coaches and players repeat the message. Focus on the next snap, ignore the noise. Indiana’s last outing was a 31-7 rout of Wisconsin, and the extra rest has helped the roster reset.

Purdue is fighting through a rebuilding year. The Boilermakers are 2-9 and winless in the Big Ten. Coach Barry Odom believes the foundation is in place and says the program is closer to competing than the record shows. Purdue will rotate quarterbacks again, starting with Ryan Browne. The Boilermakers were routed 49-13 at Washington and have been outmatched most weeks.

Indiana crushed Purdue 66-0 last season, the biggest margin in series history. Friday night’s rivalry setting still brings volatility, but the gap between these teams is wide. You can follow current movement on the updated NCAA odds page.

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Line Movement and Odds

Indiana opened around -27 and moved to -28.5 with heavy public interest. Sharp money has not opposed the line move, which signals agreement with the market. Purdue’s moneyline has climbed as high as +1900.

Current board:
• Spread: Indiana -28.5
• Moneyline: Indiana -7900, Purdue +1900
• Total: 54.5
Totals action has leaned slightly over. Indiana games have pushed scoring above 50 at a strong rate.

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Matchup Breakdown

Indiana’s path is familiar. Score early, pressure the quarterback, and force Purdue to chase the game. Fernando Mendoza sits tied for the national lead in touchdown passes and has a deep receiver room. Indiana ranks top 10 in sacks and top 15 in rushing yards. Their balance puts defenses under stress.

Purdue must create takeaways. The Boilermakers are top 10 nationally in fumble recoveries and have four interceptions. If they can flip a possession or two, they can slow the game. Browne gives them a more stable passing structure, but protection has been inconsistent. Indiana’s front is unlikely to give him clean pockets for long stretches.

Injuries and Conditions

Indiana injury notes
• Bryson Bonds, out
• Brendan Franke, questionable
• Tyler Morris, out, knee
• Elijah Sarratt, questionable, hamstring
• Kellan Wyatt, out
• Lee Beebe Jr., out, leg
• Drew Evans, questionable

See the full Indiana injury report for updates.

Purdue injury notes
• Chauncey Magwood, out
• Devin Mockobee, out
• De’Nylon Morrissette, questionable
• George Burhenn, questionable
• TJ Lindsey, out
• Jalil Hall, out, leg

Full details available on the Purdue injury report.

Weather
Clear, mid 40s, light wind. No expected impact on totals.

Best Bets and Prediction

Indiana is 21-0 straight up as a favorite across the last two seasons. They are 4-0 on the road this year and consistently handle lesser opponents. Purdue’s defense sits near the bottom of FBS in points allowed. Indiana’s pass rush should dictate pace from the opening series.

Projected score: Indiana 45, Purdue 10
Best Bet: Indiana -28.5
Secondary Lean: Over 54.5

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