Uconn Huskies vs Duke Blue Devils Picks and Predictions November 8th 2025

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Duke looks to extend its road dominance when it meets UConn in a non-conference matchup Saturday in East Hartford, Conn. The Blue Devils are 5-3 and have won three straight away games, while the Huskies (6-3) remain unbeaten at home.

Duke has road wins over Syracuse, Cal, and Clemson, scoring 38 or more points each time. The Blue Devils’ offense, led by quarterback Darian Mensah, ranks among the ACC’s most efficient. Mensah has 2,572 yards, 21 touchdowns, and only two interceptions. Receiver Cooper Barkate leads the conference in receiving yards (774).

UConn’s home offense has been elite, averaging 44.8 points at Rentschler Field. Quarterback Joe Fagnano, a Maine transfer, has thrown for 2,529 yards and 22 scores without an interception. The Huskies have committed only one turnover all season and own a plus-10 turnover margin.

Both teams come in hot, having each won five of their last six. This matchup could shape bowl positioning for two programs exceeding expectations. For more game previews and matchup breakdowns, visit the college football previews page

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Line Movement and Odds

According to the latest college football odds, Duke opened as a 2.5-point favorite, with the total at 60. Early sharp money hit the under, dropping it to 59, while public bets remain slightly tilted toward UConn at home.

The Blue Devils are -140 on the moneyline, while the Huskies sit around +120. Duke is 3-1 ATS on the road, and UConn has covered in every home game this season.

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Matchup Breakdown

Duke’s passing efficiency meets a disciplined UConn defense that thrives on takeaways. If Mensah stays clean against the Huskies’ secondary, the Blue Devils could sustain long scoring drives.

UConn’s offensive balance has been key. The Huskies run for 180 yards per game and protect Fagnano well, allowing only seven sacks through nine games. Duke’s front seven will test that with pressure rates among the ACC’s top five.

Expect tempo from both teams. Duke ranks 18th nationally in plays per game, while UConn uses quick-hitting throws to control pace.

For bettors comparing these tendencies, check the expert betting guide before placing your wager.

Injuries and Conditions

Duke Blue Devils

  • WR Jordan Moore (ankle) – Probable
  • LB Nick Morris (shoulder) – Questionable
  • OL Jacob Monk (knee) – Out

UConn Huskies

  • RB Victor Rosa (hamstring) – Questionable
  • CB Mumu Bin-Wahad (hand) – Out
  • TE Justin Joly (ankle) – Probable

Review each team’s full Duke injury report and UConn injury report before kickoff.

Weather: Partly cloudy, highs near 52°F, light winds — ideal football conditions in East Hartford.

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Best Bets and Prediction

Both offenses are efficient, but UConn’s home form and turnover discipline stand out. The Blue Devils are 5-1 ATS in their last six overall, while UConn has hit the over in four straight home games.

Projected Score: UConn 31, Duke 27
Best Bet: UConn +2.5
Lean: Over 59

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Get more insight from our Handicapper Leaderboard and premium Service Plays. You can also compare free college football picks and strategies in the Bettors Handbook

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