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Missouri Tigers vs Vanderbilt Commodores Game Preview
The Vanderbilt Commodores host the Missouri Tigers in a pivotal SEC clash on Saturday, October 25, 2025, at FirstBank Stadium in Nashville. Kickoff is set for 3:30 PM ET, and ESPN’s “College GameDay” will be on site for the marquee matchup between two ranked programs.
Both teams enter at 6-1 (2-1 SEC), marking the first time Vanderbilt and Missouri meet as ranked opponents. The Commodores are fueled by Heisman-contending quarterback Diego Pavia, who led last week’s 31-24 win over LSU. Missouri, meanwhile, aims to secure its first road victory over a Top 10 opponent since 2013.
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Line Movement and Betting Odds
Missouri Moneyline: +138
Vanderbilt Moneyline: -165
Missouri Spread: +3.5 (-110)
Vanderbilt Spread: -3.5 (-110)
Total Over/Under: 55.0 (-110)
Vanderbilt opened as a modest home favorite, driven by offensive efficiency and Diego Pavia’s dual-threat versatility. Early action has leaned slightly toward the Tigers, who continue to impress defensively under head coach Eli Drinkwitz.
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Matchup Breakdown
Vanderbilt’s offense has emerged as one of the SEC’s most explosive units, averaging 6.3 yards per carry (fourth nationally). Quarterback Diego Pavia has thrown for 15 touchdowns and added six rushing scores while taking only five sacks in 183 dropbacks. The Commodores’ offensive line, anchored by standout tackle Cade McConnell, continues to protect Pavia and create running lanes that keep defenses guessing.
Missouri counters with one of the nation’s top ground games, averaging 245 rushing yards per contest. Quarterback Beau Pribula has shown flashes of maturity, passing for 1,564 yards while adding a dynamic rushing presence. Running back Ahmad Hardy remains a key red-zone weapon with multiple multi-touchdown performances.
Defensively, Missouri thrives on front-seven pressure. Edge rusher Zion Young — fresh off two sacks and a conference honor — will be tasked with containing Pavia’s mobility. Vanderbilt’s defense, while improving, must tighten against the run after allowing 5.1 yards per carry in its last two games.
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Key Storylines
Vanderbilt continues its rise as a legitimate SEC contender under Clark Lea, climbing into the Top 10 for the first time in decades. Pavia’s efficiency and creativity have made the Commodores must-watch television, while their offensive line has quietly become one of the most dominant in college football.
Missouri, meanwhile, remains within striking distance of the SEC title picture. The Tigers have rebounded from a narrow loss to Alabama and are looking to prove they can win on the road against elite competition. Drinkwitz’s balanced offense and opportunistic defense could be the formula for an upset in Nashville.
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Injury Report
Missouri Tigers:
Quarterback Beau Pribula (ankle) practiced fully and is expected to start. Running back Ahmad Hardy (shoulder) is probable, while wide receiver Luther Burden III (hamstring) is questionable. Defensive tackle Johnny Walker Jr. (knee) is a game-time decision.
Full injury report for Missouri Tigers
Vanderbilt Commodores:
Quarterback Diego Pavia (ankle) is fully cleared after minor soreness last week. Linebacker Ethan Barr (undisclosed) and wide receiver Jayden McGowan (shoulder) are questionable. Offensive guard Grayson Morgan (knee) remains out.
Full injury report for Vanderbilt Commodores
Prediction
This Top-15 showdown is shaping up as a physical, high-tempo SEC battle. Vanderbilt’s offensive balance and home-field edge give it a slight advantage, but Missouri’s aggressive defense and ground control could keep things tight deep into the fourth quarter. Expect Pavia’s improvisation to be the difference late.
Projected Score: Vanderbilt 30, Missouri 24
Best Bet: Vanderbilt -3.5 (-110)
Secondary Lean: Under 55.0 (-110)
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