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Los Angeles Rams vs Arizona Cardinals Betting Preview
Los Angeles enters Week 14 looking for a clean response after their six-game win streak collapsed in a 31-28 loss to Carolina. Matthew Stafford opened with his record-setting 28th straight touchdown pass without an interception, but two quick turnovers shifted control and exposed execution issues. Sean McVay pointed to communication, accountability and situational lapses as the driving factors behind the setback. The Rams remain 9-3 and tied for the NFC’s best record, and the roster projects confidence that the loss was a momentary break rather than a trend.
Arizona continues a difficult season. The Cardinals have dropped four straight and nine of their last ten. Jacoby Brissett will make his eighth consecutive start with Kyler Murray still sidelined. Brissett eclipsed 300 yards again last week, and he has produced 13 touchdowns across seven starts, but protection issues persist with 26 sacks allowed. Marvin Harrison Jr. returned from an appendectomy and contributed immediately but enters this matchup managing a heel issue.
Los Angeles won three of the last four meetings, although Arizona’s lone win in that stretch was a decisive 41-10 result powered by 231 rushing yards. The Rams’ defensive structure will need sharper discipline after breakdowns on long fourth-down conversions last week, and Stafford’s efficiency must stabilize with key playmakers managing injuries.
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Line Movement and Odds
The Rams opened -8 and have held that number behind market confidence in their offensive balance and defensive ceiling. Arizona sits +8 as home support favors a potential letdown response from Los Angeles.
The total opened 48 and has remained stable. Indoor conditions reduce variance, and both offenses have produced consistent explosive-play rates.
Track updated Week 14 movement through the NFL odds board.
Matchup Breakdown
Los Angeles can dictate with rhythm and depth. Stafford remains the league leader in passing touchdowns and continues to work efficiently through Davante Adams and Puka Nacua. Adams carries a mild hamstring concern, and Kyren Williams is managing an ankle issue, but the Rams’ spacing and early-down sequencing remain among the league’s sharpest. Defensively, their turnover creation provides a stabilizing floor and allows the offense more possessions in favorable field position.
The Cardinals rely on Brissett’s volume and McBride’s consistency to sustain drives. Their passing game carries the offense, and they rank strong in sustaining first downs. Arizona’s pass rush remains competitive and can influence possessions, but injuries across the roster continue to disrupt continuity on both sides of the ball. Their margin for error narrows when protection fails, and recent late-game sequences highlight a team that competes but struggles to close.
Explore matchup projections inside the updated NFL picks section.
Injuries and Conditions
Los Angeles Rams
Davante Adams, hamstring, questionable
Rob Havenstein, ankle, out
Tyler Higbee, ankle, out
Tutu Atwell, hamstring, questionable
Kyren Williams, ankle, questionable
Roger McCreary, hip, out
Quentin Lake, elbow, out
Keir Thomas, undisclosed, out
Full depth updates available on the Rams team page.
Arizona Cardinals
Zay Jones, Achilles, out
James Conner, foot, out
Will Hernandez, hip, out
Justin Jones, undisclosed, out
Kyler Murray, foot, out
Jonah Williams, shoulder, out
Mack Wilson Sr., ribs, out
L.J. Collier, knee, out
Sean Murphy-Bunting, knee, out
Andre Baccellia, arm, questionable
Blake Gillikin, back, out
Simi Fehoko, wrist, out
Indoor venue, mild weather.
Latest Betting Trends
Rams SU as favorite: 11-2
Rams ATS as favorite: 10-3
Rams SU after loss: 3-0
Cardinals O/U home: 4-0
Cardinals O/U all games: 6-2
Cardinals O/U as underdog: 5-2
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Best Bets and Prediction
Los Angeles carries a clear matchup edge across offensive efficiency, defensive structure and late-game stability. Arizona competes, but protection concerns and personnel limitations narrow their scoring paths. The Rams project a controlled rebound performance.
Projected Score: Rams 30, Cardinals 20
Best Bet: Rams -8
Secondary Lean: Over 48
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