Carolina Panthers vs Atlanta Falcons Picks and Predictions September 21st 2025

Carolina Panthers vs Atlanta Falcons September 21st 2025

The Atlanta Falcons and Carolina Panthers are set to meet in a game of the NFL week 3. The game will take place at Bank of America Stadium in Charlotte, NC. Fans can catch the action on FOX, with kickoff scheduled for 1:00 PM on Sunday, September 21, 2025.

The Falcons come into the game with a 1-1 record, having won their only road game so far. The Panthers are still searching for their first win of the season, standing at 0-2. Weather conditions are expected to be clear with a light breeze, making for a pleasant day of football.

Falcons vs Panthers Key Information

• Sport: NFL
• Teams: Atlanta Falcons vs. Carolina Panthers
• Venue: Bank of America Stadium in Charlotte, NC
• Date: Sunday, September 21, 2025
• Betting Odds: Falcons Moneyline -249, Panthers Moneyline +204, Falcons Spread -5.5 (-108), Panthers Spread +5.5 (-111), Total Over 43.5 (-109), Total Under 43.5 (-112)

The Falcons Can Win If…

The Atlanta Falcons are coming off a solid victory against the Minnesota Vikings, winning 22-6. Their defense was strong, forcing four fumbles and grabbing two interceptions. On offense, Bijan Robinson led the ground game with 143 rushing yards, while Tyler Allgeier added a rushing touchdown.

Key stats show why the Falcons can win this game. They rank 5th in passing yards from last season, indicating a potent air attack. Their defense is also formidable, ranking 8th in opponent passing interceptions, which could disrupt the opposing quarterback.

Injuries may impact the Falcons, but their depth remains strong. Michael Penix Jr. is projected to throw over 230 yards with no interceptions. If Bijan Robinson continues his form, he is expected to gain over 80 rushing yards, making the Falcons a tough team to beat.

The Panthers Can Win If…

The Carolina Panthers recently played against the Arizona Cardinals, losing 27-22. Despite the loss, Bryce Young showed his skills with 328 passing yards and three touchdowns. Hunter Renfrow contributed with two touchdown receptions, and Tetairoa McMillan added 100 receiving yards.

Carolina’s passing game is a strong point, with Bryce Young ranking 11th in the league for passing yards. The team also achieved 26 first downs against Arizona, indicating their ability to move the chains. Their offense can be a threat, especially if they improve their rushing attack.

On defense, the Panthers have shown they can recover fumbles, ranking 7th in the league. Tre’von Moehrig is a key player, leading with tackles in recent games. If the defense can hold strong, the Panthers have a solid chance to win their next game.

Latest Betting Trends

• The Falcons are 37-23 all-time against the Panthers, including 16-14 in Charlotte.
• These teams have split the season series in each of the last five years, highlighting how competitive this rivalry has been.
• Atlanta has covered the spread more consistently when Robinson has been heavily featured in both the rushing and passing game.
• Carolina has struggled offensively in its first two games, failing to establish the run, but home openers have historically given them a boost.
• Divisional games between these two franchises have often been close, making spreads and totals worth monitoring on the NFL scores and odds

The Lean

The Atlanta Falcons are favored by 5.5 points against the Carolina Panthers. The Falcons have a strong ATS record as favorites, going 6-0 in their last six regular season games. Given the Panthers’ struggles, my model projects the Falcons to win 27-20, covering the spread.

The total for the game is set at 43.5. The Panthers have gone over the total in their last four home games. Considering both teams’ defensive rankings, my model projects a total score of 47. I recommend betting on the over.

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Falcons Building Momentum After Win

The Atlanta Falcons travel to Charlotte for a key divisional matchup with the Carolina Panthers, looking to build on their strong defensive performance in last week’s 22-6 victory at Minnesota. Head coach Raheem Morris stressed to his young roster that every week in the NFL is “primetime,” emphasizing consistency and energy.

Quarterback Michael Penix Jr. has shown flashes but noted the offense has yet to play its best game. With more balance between the run and pass, he believes Atlanta can become one of the most dynamic units in the league. Fans can track all upcoming matchups and analysis through the NFL previews

Bijan Robinson Emerging as a Star

Running back Bijan Robinson has quickly become Atlanta’s centerpiece, producing 167 rushing yards and 125 receiving yards in the first two games. Morris elevated his status further, calling him “the best player in football.” Robinson’s dual-threat ability gives the Falcons a versatile edge that could exploit Carolina’s defense. Bettors keeping an eye on Robinson and the Falcons can follow the latest NFL picks throughout the season.

Panthers Searching for Offensive Flow

The Panthers enter their home opener at 0-2 after losses at Jacksonville and Arizona. Despite a sluggish offensive start, head coach Dave Canales reaffirmed his confidence in Bryce Young, who will remain the starter. Young’s best career game came against Atlanta last January when he threw three touchdowns and added two rushing scores in a 44-38 win.

Carolina’s running game sputtered last week with just 49 rushing yards, a concern that could resurface against Atlanta’s defensive front. With their revamped offensive line missing Robert Hunt and Austin Corbett, Cade Mays shifts to center while Chandler Zavala fills in at right guard. For more team updates, visit the NFL teams page

Injury Concerns on Both Sides

Atlanta’s secondary is dealing with the loss of cornerback A.J. Terrell Jr., sidelined by a hamstring injury. Dee Alford and Clark Phillips III are competing for his spot. Other injuries include James Pierce Jr., Charlie Woerner, Jamal Agnew, Darnell Mooney, and Jamal Washington, potentially thinning the Falcons’ depth.

Carolina is also banged up, with Patrick Jones II, Tershawn Wharton, and Xavier Legette all on the injury report. The offensive line adjustments will be under heavy scrutiny against Atlanta’s pass rush. Fans can review all outcomes and past performances on the NFL game results

Outlook

Atlanta comes in with momentum and a star in Robinson, while Carolina looks to turn its season around behind Young in front of its home fans. With both teams aiming to gain ground in the NFC South, this matchup should provide plenty of intrigue.

For deeper insights, bettors can access the NFL expert betting guide shop premium buy picks or check the latest leaderboard of the best handicappers