Packers vs Browns Prediction, Odds, and Betting Trends

Cleveland Browns vs Green Bay Packers September 21st 2025

The Green Bay Packers will visit the Cleveland Browns in Week 3 of the 2025 NFL season. The game is set for Sunday, September 21, at Huntington Bank Field in Cleveland. Fans can catch the action on FOX at 1:00 PM. The weather forecast predicts a mild day with a light breeze and broken clouds.

The Packers come into this game with a 2-0 record, led by head coach Matt LaFleur. They have shown strength at home and in their division. The Browns, under head coach Kevin Stefanski, are looking for their first win of the season after starting 0-2. The Browns aim to improve their home record in front of their fans. For a full breakdown of matchups and betting insights across the slate, check out our detailed NFL Week 3 blog.

Packers vs Browns Key Information

Sport: NFL
Teams: Green Bay Packers vs. Cleveland Browns
Venue: Huntington Bank Field in Cleveland, OH USA
Date: Sunday, September 21, 2025
Betting Odds: Packers Moneyline -431, Browns Moneyline +336, Packers Spread -7.5 (-108), Browns Spread +7.5 (-111), Total Over 41.5 (-111), Total Under 41.5 (-110)

The Packers Can Win If…

The Green Bay Packers are coming off a strong win against the Washington Commanders, 27-18. Quarterback Jordan Love led the way with 292 passing yards and two touchdowns. Tight end Tucker Kraft was a key target, racking up 124 receiving yards and one touchdown.

The Packers’ offense is showing strength, ranking 12th in passing yards and 5th in rushing yards from last season. Jordan Love is currently ranked 1st in the league for passing yards and touchdowns. This offensive firepower gives the Packers a solid chance to win.

Defensively, the Packers are tough, ranking 6th in opponent scores and sacks last season. They also ranked 3rd in opponent passing interceptions. With this kind of defense, the Packers can disrupt the opposing team’s offense and control the game.

The Browns Can Win If…

The Cleveland Browns are looking to bounce back after a tough 41-17 loss to the Baltimore Ravens. Despite the loss, the Browns showed strength in their running game, with 115 rushing yards compared to the Ravens’ 45. Myles Garrett was a standout on defense, recording 1.5 sacks, which could be key in applying pressure in their next game.

Joe Flacco leads the Browns’ passing attack with 489 yards over two games, ranking first on the team. Cedric Tillman has been a reliable target, catching two touchdowns this season. The Browns’ ability to move the chains is evident, as they recorded 22 first downs against the Bengals, showing they can sustain drives.

The Browns’ defense is capable of making big plays, with a rank of 8th in sacks last season. They also recovered eight fumbles, ranking 7th, indicating their knack for creating turnovers. Playing at home, the Browns will look to capitalize on these strengths to secure a win.

Latest Betting Trends

The Packers are 4-0 straight up and against the spread in their last four meetings with the Browns.
Green Bay has covered the spread in six of its last seven games overall.
The Browns are 1-5 ATS in their last six home games.
The under has hit in four of the last six matchups between these two teams.
Joe Flacco is 2-6 in his last eight starts against NFC opponents.
The Packers have gone under the total in five of their last seven road games.

The Lean

The Green Bay Packers are favored by 7.5 points against the Cleveland Browns. The Packers have a strong ATS record as favorites, going 12-0 in their last 12 games. With the Browns’ struggles, especially at home, the recommendation is to pick the Packers to cover the spread. The projected score is Packers 28, Browns 14.

The total for the game is set at 41.5 points. The Packers have been under the total in 6 of their last 9 games as favorites. The Browns have a tendency to go over in games with totals of 42 or less. Given the projected score of 28-14, the recommendation is to take the under for this game.

Packers Seek 3-0 Start on the Road

The Green Bay Packers head on the road for the first time this season as they look to begin 3-0 for the first time since 2020. Their opponent will be the Cleveland Browns, who are still searching for their first win after back-to-back losses.

Green Bay enters the matchup following a 27-18 victory over the Washington Commanders on Thursday night and a strong opening win over the Detroit Lions. Cleveland, meanwhile, fell 41-17 at Baltimore after dropping their opener to Cincinnati.

For more team updates and season coverage, visit the NFL teams page

Defensive Dominance Fuels Packers’ Confidence

The Packers’ defense has been a key storyline early in the season. The addition of Micah Parsons before Week 1 has immediately boosted their pass rush, with the unit yet to allow a first-half touchdown. Green Bay has already racked up eight sacks, tied for second in the league.

Head coach Matt LaFleur highlighted concerns with injuries to right tackle Zach Tom and left guard Aaron Banks, which could affect protection. Despite that, the Packers’ defensive front has been relentless in setting the tone.

Check out the latest NFL previews for more breakdowns on upcoming games.

Joe Flacco Under Pressure

Veteran quarterback Joe Flacco has been forced to throw often, attempting 90 passes across two games. However, he has struggled against aggressive defenses, as shown in last week’s loss at Baltimore where he was hit nine times and committed two turnovers.

Cleveland’s offensive line health is a major concern, with Joel Bitonio and Jack Conklin both limited. If the Browns cannot contain Green Bay’s rush, Flacco could be in for another long day.

Explore expert breakdowns in the NFL expert betting guide to see how matchups like this can impact wagering.

Cleveland’s Defense Remains a Strength

Despite the rough start, the Browns have held opponents to just 191.5 yards per game, leading the NFL in total defense. They have been especially strong against the run, surrendering only 91 yards on 44 carries through two weeks.

That sets up a pivotal test against Packers running back Josh Jacobs, who has rushed for 150 yards and two touchdowns while scoring in 10 consecutive games. If Cleveland can bottle up Jacobs, Jordan Love will need to continue his efficiency downfield.

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Jordan Love’s Efficient Start

Jordan Love has quietly been one of the most efficient quarterbacks in the league, completing 66 percent of his passes for 480 yards, four touchdowns, and no interceptions. He leads the NFL with 12.5 air yards per attempt and has spread the ball to 11 different receivers.

Tight end Tucker Kraft has emerged as a red-zone threat with two touchdowns, while Jayden Reed’s absence due to surgery will test Green Bay’s depth. Love enters the game with a streak of nine consecutive contests without throwing an interception.

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Injury Notes and Game Impact

Both teams are dealing with key injuries. Cleveland has concerns on the offensive line and defense, while Green Bay is monitoring Jacobs and multiple offensive linemen. The health of these players could heavily influence Sunday’s outcome.

Review the latest NFL game results to track how injuries and matchups have shaped recent outcomes.

Historical Edge with Green Bay

Green Bay has had Cleveland’s number, winning four straight games and six of the last seven meetings. With the Packers riding momentum and the Browns fighting early-season struggles, history favors LaFleur’s team heading into Sunday.

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Cleveland Browns vs Green Bay Packers Picks and Predictions September 21st 2025