Texans vs Titans NFL Week 4 Preview

Houston Texans vs Tennessee Titans September 28th 2025

The Tennessee Titans are set to visit the Houston Texans in Week 4 of the 2025 NFL season. Both teams are looking to secure their first win, with the Titans holding a 0-3 record and the Texans also at 0-3. The game will take place at NRG Stadium in Houston, where the retractable roof will likely keep weather conditions from affecting play.

This AFC South showdown will be broadcast on CBS at 1:00 PM on Sunday, September 28. The Titans, led by head coach Brian Callahan, are aiming to improve their road record. Meanwhile, Texans head coach DeMeco Ryans hopes to capitalize on home-field advantage to turn the season around. Both teams will look to gain momentum in their division with a victory.

Titans vs Texans Key Information

Sport: Football (NFL)
Teams: Tennessee Titans vs. Houston Texans
Venue: NRG Stadium in Houston, TX
Date: Sunday, September 28, 2025
Betting Odds: Titans Moneyline +288, Texans Moneyline -361, Titans Spread +7.0 (-108), Texans Spread -7.0 (-111), Total Over 38.5 (-111), Total Under 38.5 (-109)

The Titans Can Win If…

The Tennessee Titans are looking to bounce back after their recent loss to the Indianapolis Colts, where they fell 41-20. Cameron Ward led the offense with 219 passing yards and a touchdown. Tony Pollard added 45 rushing yards and a touchdown, showing his ability to contribute on the ground.

Despite their recent setbacks, the Titans have players capable of making big plays. Cameron Ward ranks first in the league for passing yards among quarterbacks with 506 yards. Tony Pollard is also a key player, ranking first in rushing yards for the team with 197 yards, placing him 11th in the league.

On defense, the Titans have shown their ability to create turnovers, ranking ninth in opponent passing interceptions last season. Amani Hooker and Xavier Woods are both consistent performers, each recording five solo tackles in their last game. The Titans will aim to capitalize on these strengths to secure a win in their upcoming game.

The Texans Can Win If…

The Houston Texans are looking to bounce back after a close loss to the Jacksonville Jaguars, 17-10. Nico Collins had a strong performance with 104 receiving yards and a touchdown. C.J. Stroud threw for 204 yards and a touchdown, but also had two interceptions.

Houston’s defense has been a bright spot, ranking 4th in sacks and 2nd in opponent passing interceptions last season. This defensive strength gives them a chance to disrupt the opposing team’s offense. With players like Will Anderson Jr. and Jalen Pitre making key plays, the defense can be a game-changer.

Offensively, the Texans have shown potential with Nick Chubb and Nico Collins leading the charge. Chubb is projected to contribute over 60 rushing yards, while Collins is expected to add significant receiving yards. With a focused game plan, Houston can capitalize on these strengths to secure a win at home.

The Lean

The Houston Texans are favored by 7.0 points against the Tennessee Titans. The Titans have struggled against the spread as underdogs, going 1-2 in their last three games. Meanwhile, the Texans have been strong as favorites, with a 6-1 record in their last seven games. Given these trends, the pick is for the Texans to cover the spread. The projected score is Texans 24, Titans 13.

The total for the game is set at 38.5. The Titans have hit the over in 10 of their last 15 games, especially when playing as underdogs. The Texans have also seen the over in games with totals set at 42 or less, going 4-0 recently. Considering both teams’ tendencies, the recommendation is to take the over. The projected total score is 37, slightly under the line, but trends suggest a higher-scoring game.

Texans vs Titans Preview

The Houston Texans (0-3) and Tennessee Titans (0-3) clash Sunday in an AFC South matchup where one side will finally pick up a win. Houston’s offense ranks last in scoring at 12.7 points per game, wasting a defense that sits tied for fifth in fewest points allowed.

C.J. Stroud has struggled with timing and protection behind an inconsistent line, while Tennessee rookie Cam Ward has been sacked a league-high 15 times. Both units enter this week with major concerns in the trenches.

Injury Report

Houston’s Derek Stingley Jr. (oblique) remains doubtful after missing back-to-back practices. Right tackle Tytus Howard (illness) returned Thursday and should play.

Tennessee’s offensive line is even more battered. JC Latham (hip) has yet to practice, while Kevin Zeitler (biceps) was limited. Ward is also listed with ankle and calf issues, but he’s expected to start.

Betting Results and Trends

Oddsmakers opened this as a near pick’em on the NFL odds page. Houston is 0-3 ATS with two Unders, dragged down by scoring inefficiency. Tennessee is also 0-3 ATS, leaning Under as well, thanks to one of the league’s lowest-ranked offenses. With two struggling units, totals will draw sharp betting attention.

What It Means Moving Forward

The Texans need cleaner protection for Stroud to translate defensive stops into wins. For the Titans, new play-caller Bo Hardegree aims to spark Ward’s development and a stagnant offense. Whoever controls the line of scrimmage could decide this divisional outcome.

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Houston Texans vs Tennessee Titans Picks and Predictions September 28th 2025