Time flies, doesn’t it? Week 4 of the 2024 NFL season is already upon us, which means we’re already closing in on the quarter pole of the campaign. Offense is still down around the NFL, and we’ve seen what feels like an incredible number of upsets on a weekly basis.

Week 4 offers a full slate of games kicking off with an NFC East rivalry clash between the Dallas Cowboys and New York Giants on Thursday Night Football. We’ll also cap our football weekend with our second straight Monday Night Football doubleheader. The Miami Dolphins will play host to the Tennessee Titans in the early game, while the Seattle Seahawks will visit the Detroit Lions in the nightcap.

As always, we’ve got you covered with comprehensive NFL Week 4 odds and predictions for every game on the docket. Our in-depth analysis will help you make informed picks, whether you’re betting straight up, against the spread, or considering over/under totals.

Here’s how we’re approaching the Week 4 matchups. Read on for our favorite NFL picks from each game.

NFL Week 4 Schedule

NFL Week 4 Odds

The first thing you notice when inspecting the NFL odds for week 4 is undeniably the Buffalo Bills being a massive 13.5 point favorite.

Buffalo has the largest spread of the week. They are obviously very likely to win and probably the safest straight up pick of the week, but NFL bettors might not be able to ignore the NFL week 4 moneyline for the Saints. The Bills are not alone as huge week 4 betting favorites, though, as the Lions are favored by 10 at home versus the lowly Browns.

Of course, the rest of week 4 isn’t quite as one-sided. A whopping 11 games have a spread of 4.5 or tighter, making this an entertaining and potentially unpredictable week of NFL betting action.

NFL week 4 spreads might be tough to figure out, but I think we’re in for some fireworks across the board. That should mean for some fun NFL week 4 totals betting, while we can probably bet more confidently on some of our favorite NFL underdog picks.

The primetime games are all shaping up to be epic battles, too. The game in London has a one-point spread, while the MNF double-header has two games with NFL week 4 lines of 6.5 or better.

The NFL week 4 lines look pretty good across the board, making this a fun week to place some  bets at your favorite sports betting sites. I’ll walk you through the pricing and matchup history before handing out game predictions, but if you want even more help, be sure to take advantage of the best handicappers the internet has to offer.

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NFL Week 4 Predictions

Let’s take a look at the full slate of NFL Week 4 matchups and make our NFL picks for each game.

Seattle Seahawks vs. Arizona Cardinals Odds

The first game of week four will go down between the Seattle Seahawks and Arizona Cardinals on Thursday Night Football. It’s a battle between two familiar teams, as both Seattle and Arizona battle for positioning within the NFC West.

The two sides have met 52 times, with Seattle leading the series, 29-22-1. The Seahawks won 30-18 in the last meeting in 2024, and also swept the season series last season. Seattle has won seven games in a row as well.

Seattle Seahawks vs. Arizona Cardinals Predictions

The Seattle Seahawks have had the upper hand throughout this series, but things could be shifting in 2025. Seattle has a new quarterback under center with Sam Darnold in the fold, and lost a key weapon with D.K. Metcalf now in Pittsburgh.

With this game being on a short week, at night, and on the road, I tentatively lean toward the Arizona Cardinals getting the win. Kyler Murry and co. have endured a roller coaster tenure, but the Cards do have some nice talent on offense and should improve defensively.

At home against a team they know well, I like AZ to get a big primetime win to end their losing streak in this series.

Bet: Arizona Cardinals (-130), Arizona Cardinals -2.5 (-105)

Minnesota Vikings vs. Pittsburgh Steelers Odds

The Pittsburgh Steelers technically host the Minnesota Vikings in week 4, but this game will actually be played in Ireland. If the Steel Curtain can find a way to win this one, it could go a long way in boosting their chances of taking down the brutal AFC North.

Pittsburgh hasn’t done that since 2020, so they should be focused on a fast start this season. The same can be said for week 4, as the Vikings own the series advantage (10-9) and put up 36 points in a win the last time these two sides faced.

Minnesota Vikings vs. Pittsburgh Steelers Predictions

This is the second year in a row Aaron Rodgers will be facing the Vikings overseas. Rodgers notoriously hates these games, but he’s with a new team now – one that is seemingly not as dysfunctional as New York.

Pittsburgh finally got their quarterback upgrade, which in theory gives them a bump and may even ultimately make them a title threat. Minnesota, meanwhile, still has questions to answer with the young J.J. McCarthy running the show.

On a neutral field, I give the edge to the Steelers. Their defense still has bite, Rodgers has added upside to their offense, and I don’t fully trust McCarthy yet.

Bet: Pittsburgh Steelers (+100), Pittsburgh Steelers +1 (-105)

Washington Commanders vs. Atlanta Falcons Odds

The Washington Commanders travel to Georgia to take on the Atlanta Falcons in week 4, giving fans a possible NFC playoff preview. The two sides met last year and gave fans quite a treat, as the game went into overtime, where the Commanders prevailed, 30-24.

Washington has dominated this series (19-10-1) across 30 meetings, and have racked up four consecutive wins against Atlanta.

Washington Commanders vs. Atlanta Falcons Predictions

The Atlanta Falcons have a chance to be the kings of the NFC South if they can get off to a hot start, but winning games like this at home against fellow playoff contenders won’t be easy.

Washington was a mixed bag of luck and talent in Jayden Daniels’ first year on the job, so I can see some regression in store for the Commanders. Michael Penix is a total wild card on the other side, but when you look at the talent on Atlanta’s offense – namely Bijan Robinson – it’s hard to go away from them.

This is a game where I’d bet on the Over regardless of where it’s set, but the Falcons at +3.5 as a home dog is too good to pass up.

Bet: Atlanta Falcons (+145), Atlanta Falcons +3.5 (-120), Over 48.5 (-110)

New Orleans Saints vs. Buffalo Bills Odds

The Buffalo Bills play host to the New Orleans Saints in week 4, giving them a gimme game on their journey to get back to the AFC Championship. Despite that fact, the Bills will face a team they’ve only battled 12 times before, while New Orleans has had the edge (7-5) in the series.

Buffalo dominated the last meeting in 2021 (31-6), however, which is probably an astute representation of what we can expect in this game. New Orleans is 4-1 over the last five meetings, but that looks to be a severely misleading stat.

New Orleans Saints vs. Buffalo Bills Predictions

The Buffalo Bills have the reigning NFL MVP in Josh Allen and are without a doubt one of the best NFL teams for 2025. Naturally, they are nearly two touchdown favorites at home against the Saints.

New Orleans was already not great in 2024, but now they have serious issues under center. They have a rookie quarterback running the show, so keeping up with Buffalo’s offense should prove difficult.

Buffalo is a slam dunk ML pick and I think this is a rare case where we can feel good about a team covering a 13-point spread.

Bet: Buffalo Bills (-625), Buffalo Bills -13 (EVEN)

Cleveland Browns vs. Detroit Lions Odds

The Cleveland Browns have a tough assignment in week four, when they head to Michigan to take on the mighty Detroit Lions. This inter-conference clash has surprisingly happened 25 times already, with Detroit dominating with a 19-6 record.

Cleveland did manage to trip up the Lions in a 13-10 slugfest back in 2021, but the Lions have won four of the last five meetings. The last matchup was also four years ago, and these teams are in very different places now.

Cleveland Browns vs. Detroit Lions Predictions

The Detroit Lions were in the NFC Championship game two years ago and last year looked like a sure bet to get to their first Super Bowl. While it didn’t go as planned, Dan Campbell’s crew certainly looks like the team to beat in this matchup.

Detroit has plenty of questions to answer in 2025, from losing both of their top coordinators to watching center Frank Ragnow retire, but betting on them to lose to the Cleveland Browns isn’t something I am willing to do.

Myles Garrett stayed in town and this Browns defense is capable enough, but a woeful offense should have the Dawg Pound coming up very short in Detroit.

Bet: Detroit Lions (-520, Detroit Lions 10.5 (-105)

Tennessee Titans vs. Houston Texans Odds

The Houston Texans host the rival Tennessee Titans in a tense AFC North showdown in week 4, with C.J. Stroud and co. expected to get the win.

The top pick in the draft will get a chance to face Houston for the first time in his career, whereas his Titans brethren have compiled a 24-22 record in this series prior to his arrival. 

Most of these games have been pretty tight, but Houston has been the more competitive team lately, snagging wins in four of the last five meetings.

Tennessee Titans vs. Houston Texans Predictions

This is a feel it out type of year for the Tennessee Titans, who drafted Cam Wad #1 overall and really won’t know what type of team they are for a while. Naturally, we also won’t know how to judge them until mid-season at the earliest.

If this meeting was in Tennessee, I’d give the Titans a shot, as divisional games can go either way. However, the Texans appear to be loaded offensively and have the edge on defense and in the coaching department. They’re also at home, so while the Titans are a threat to keep this close, I tend to side with Houston.

Bet: Houston Texans (-245), Houston Texans -6 (-105)

Carolina Panthers vs. New England Patriots Odds

The Carolina Panthers take on the New England Patriots in week four, giving fans a fun battle between young quarterbacks in Bryce Young and Drake Maye.

There isn’t a ton of history in this inter-conference clash. New England won the only Super Bowl meeting back in 2004, while these two sides have faced off just seven other times. The series is a split right down the middle (4-4), so the 2025 winner will have some bragging rights.

New England did take the last game (24-6), but that game was back in 2021 and shouldn’t have much say in what transpires in week four.

Carolina Panthers vs. New England Patriots Predictions

This game could admittedly go either way, as neither of these teams were very good in 2024, and their future hinges on the development of their prized quarterbacks.

Bryce Young did show solid improvement down the stretch last year, though, and Carolina has been aggressive in adding weaponry around him. The Panthers should also be improved on defense.

That said, the Pats now have Mike Vrabel roaming the sidelines, and they added some impact players on offense, too – namely the signing of Stefon Diggs. If Drake Maye can start to take that next step, New England could be a solid value bet at home in week four.

Bet: New England Patriots (-175), New England Patriots -3.5 (-115)

Los Angeles Chargers vs. New York Giants Odds

The Los Angeles Chargers head to the Big Apple to take on the New York Giants in week four, setting up just the 14th meeting between these two sides.

L.A. holds an 8-5 series advantage, and has crushed the NYG routinely, winning each of the last five games. They last faced off in 2021, which resulted in a 37-21 win for the Bolts. 

Los Angeles Chargers vs. New York Giants Predictions

Jim Harbaugh turned the Bolts into a legit title contender last year, but after flaming out in the playoffs and losing key pass rusher Joey Bosa, it’s worth wondering if L.A. takes a step back this year.

Even if you don’t buy a possible slide, traveling across the country and playing in New York is no joke. Plus, the G-Men upgraded their quarterback position and have added more useful pieces to an increasingly menacing defense.

The Chargers are the better team, but sometimes it’s not about who you play, but when and where. The home field edge is pretty big here for the Giants, making them a fun value bet. I like New York to cover the field goal spread, but drop the game.

Bet: Los Angeles Chargers (-175), New York Giants +3.5 (-110)

Philadelphia Eagles vs. Tampa Bay Buccaneers Odds

The Tampa Bay Buccaneers have had the Philadelphia Eagles’ number of late. They upset them in the playoffs two years ago, and also dominated them in a regular season clash last year.

Overall, the Bucs have really taken it to Philly over the years. They hold a slim 13-11 series edge, but have won four of the last five meetings.

Philadelphia Eagles vs. Tampa Bay Buccaneers Predictions

The Philadelphia Eagles are the defending champs and will probably coast to another NFC East crown, but games like these do give you cause for pause. 

First off, the Bucs are a talented team and they’re at home. Secondly, they smoked this Philly team in this same setting a year ago. Equipped to go to war with all types of explosive offenses, I wouldn’t put it past the Buccaneers to be Philly’s kryptonite.

Philadelphia is only favored by one for a very good reason, but they’re still the better team. I’d prefer this price to be a bit friendlier if you’re going on the Bucs side. As it stands, I’ll bet on the Eagles to upend the Bucs for the first time in their last three tries.

Bet: Philadelphia Eagles (-180), Philadelphia Eagles -1 (-115)

Indianapolis Colts vs. Los Angeles Rams Odds

The Los Angeles Rams host the Indianapolis Colts in week four in a game where they are nearly touchdown favorites. While L.A. is the superior team on paper, Indy holds the series edge (23-22-2).

Los Angeles has been much more successful in the series in recent years, of course. The Rams won the most recent meeting in a 29-23 OT thriller, which was their fourth consecutive win versus the Colts.

Indianapolis Colts vs. Los Angeles Rams Predictions

The NFL is known for upsets, but betting on the Colts to travel across the country and upset the Rams feels silly. Indy has a shaky quarterback room, which has held them back for years and should be no different this year.

Indy does have a stud running back in Jonathan Taylor, but they are steep underdogs for a reason. The Rams, meanwhile, have better coaching and still have a lethal passing game led by Matthew Stafford.

L.A. is the easy pick here, and I wouldn’t be shocked if they covered the spread, either.

Bet: Los Angeles Rams (-290), Los Angeles Rams -6.5 (-110)

Jacksonville Jaguars vs. San Francisco 49ers Odds

The Jacksonville Jaguars will have their work cut out for them in week four, when they head to the Bay Area to battle the San Francisco 49ers. This is another team facing a brutal hike across the country, which naturally paints the Niners as the clear favorites.

San Francisco has been the better team throughout both team’s histories in the league, and that’s been the case in their head to head meetings, too. The 49ers own a stout 5-2 record overall and have won five in a row in this series, including a 2023 clash (34-3).

Jacksonville Jaguars vs. San Francisco 49ers Predictions

The Jacksonville Jaguars can be surprisingly decent at times, and they do have some nice weapons for Trevor Lawrence to go to war with. However, the Jags were not good in 2024 and there isn’t much to suggest they’re on the same level as the Niners.

San Francisco wasn’t a lot better last year, but they were cut down by a rash of injuries. If healthy for this week 4 home stand, the Niners are the far more talented team and they’ll obviously be much more rested.

Should that be the case, this is a very tight line that should be a lot thicker.

Bet: San Francisco 49ers (-225), San Francisco 49ers -4.5 (-120)

Baltimore Ravens vs. Kansas City Chiefs Odds

The Baltimore Ravens and Kansas City Chiefs are notorious for intense showdowns. KC owns a 9-5 series edge and has won four of the last five meetings, but a lot of these games have been close.

The most recent clash was a 27-20 nail-biter in the season opener, while the Chiefs edged out the Ravens 17-10 in the playoffs the year prior. Five of the last six meetings have come down to just one score, though, setting up another potential barn burner in KC.

Baltimore Ravens vs. Kansas City Chiefs Predictions

Patrick Mahomes and co. are rarely tested within the AFC West (champions 9 years running), so games like these can be used as true tests for future playoff runs. KC could obviously suffer from a Super Bowl hangover, but they remain one of the better teams in football and are also extremely tough to beat at home.

Lamar Jackson and the Ravens have a physical and dynamic offense, as well as a capable defense. I can definitely see Lamar and Derrick Henry dominating here, but when you look at KC’s defensive aptitude and home field edge (33-9 at home over the last five years), it feels like a silly bet.

If the spread were wider, I’d give Baltimore a shot, but with this game priced virtually as a pick’em, I have to go with the Chiefs.

Bet: Kansas City Chiefs (-120), Kansas City Chiefs -1 (-110)

Chicago Bears vs. Las Vegas Raiders Odds

The Chicago Bears and Las Vegas Raiders have only met 17 times in league history, and it’s been a tough call most times, with the Bears holding a slight 9-8 edge, all-time.

Chicago won the last meeting (30-12) in 2023, and has taken three of the last four games in the series. 

Chicago Bears vs. Las Vegas Raiders Predictions

The Chicago Bears are sleeper picks to be crowned NFC North champions in 2025, and if they’re going to live up to that billing, they need to take care of teams like the Raiders.

Chicago boasts a stellar defense that is only improving, while second-year passer Caleb Williams has loads of talent around him. Maxx Crosby could still potentially feast on a Bears o-line that struggled a year ago, of course, while the Raiders have their own optimism with studs like Ashtony Jeanty and Brock Bowers hitting the field.

Las Vegas is interesting and they’re at home, but I feel like the Bears are in for a massive jump and losing to the Raiders isn’t the type of outcome that will allow that to happen.

Bet: Chicago Bears (+100), Chicago Bears -1 (-115)

Green Bay Packers vs. Dallas Cowboys Odds

NFL fans get a gem on Sunday Night Football in week 4, with the Green Bay Packers heading to Big D to battle the Dallas Cowboys.

These two sides have faced off 39 times, with Green Bay holding a 22-17 advantage. The Packers won the last meeting in a wild playoff upset (48-32), and have dominated lately with five consecutive victories and a 10-1 mark over the last 11 meetings.

Green Bay Packers vs. Dallas Cowboys Predictions

The Packers head to Big D for a huge NFC battle on Sunday Night Football in week 4. Green Bay has a rough schedule to start the year, and this tough road game is certainly part of that.

While winning this game won’t be easy, these teams have been heading in different directions over the past couple of years. Green Bay’s defense has improved and their offense is as dynamic as anyone’s, while a coaching change and a regressing defense have Dallas looking like a tough team to trust.

This is certainly one where I anticipate a good amount of points being scored, but the Packers should be able to find a way to pull out the win. Needless to say, this could be a great game to hammer the Over on a lot of NFL player prop bets.

Bet: Green Bay Packers (-120), Green Bay Packers -1 (-110)

New York Jets vs. Miami Dolphins Odds

The New York Jets will hope to upend the Miami Dolphins on the road in week 4, which could give them an edge inside the AFC East division. These two teams know each other extremely well, having faced off 119 times already.

This series has been back and forth throughout history, but Miami holds the overall edge with a 61-57-1 record. The Dolphins have been more successful recently, too, claiming wins in four of the last meetings.

New York did get the last laugh in the most recent showdown, however, with Gang Green prevailing 32-20.

New York Jets vs. Miami Dolphins Predictions

Justin Fields and co. head to South Beach in week 4, where they will battle the AFC East rival Dolphins in game one of a Monday Night Football double-header.

This is one of the tougher games to call for week 4, seeing as Miami does still have a capable offense, and the Jets were a mitigated disaster last season. While Fields should make Gang Green interesting, I’ll need to see major strides before I back them to get big road wins like this.

Miami head coach Mike McDaniel is on his last legs, so huge divisional clashes like this need to go his way. Assuming quarterback Tua Tagovailoa can stay upright in this one, I like the Fins to get the W.

Bet: Miami Dolphins (-225), Miami Dolphins -6 (EVEN), Under 44.5 (-110)

Cincinnati Bengals vs. Denver Broncos Odds

The Cincinnati Bengals and Denver Broncos will face off in back-to-back seasons for the first time since 2018. Denver holds a commanding 22-12 all-time series edge, but has slipped of late, losing three of the last four meetings.

Cincy had the upper hand last year, where they won a wild 30-24 overtime contest to keep their playoff hopes alive.

Cincinnati Bengals vs. Denver Broncos Predictions

The second Monday Night Football matchup for week 4 features two potential playoff threats in the Bengals and Broncos. Cincinnati again has a swiss cheese-like defense, so they will depend mightily on Joe Burrow to elevate them in the AFC North.

Denver gets a home game under the bright lights, which should mean good things for second-year quarterback Bo Nix. He led the Broncos to a playoff game in his first year on the job, while a date with Cincy’s defense is far from imposing.

The Broncos have a stifling defense, but the Bengals have so much firepower that I still expect some points to be had here. This one should go down to the wire, but better coaching and a better defense give the Broncos the edge at home.

Bet: Denver Broncos (-135), Denver Broncos -2.5 (-110)

NFL Week 4 Best Bets

You can pick and choose with week 4 NFL picks you use, but these are my favorite week 4 NFL bets:

• Buffalo Bills -13 (EVEN)
• Chicago Bears -1 (-115)
• Kansas City Chiefs -1 (-120)

I also like the Lions to cover their big spread against Cleveland, but the Browns at least have a good defense, so I think Buffalo is the safer play. Thirteen points is steep, but the Bills are fully capable of getting it done against a team with a major quarterback quandary.

Chicago is a serious sleeper team I have my eye on this year, so I’ll be high on them in any tight affairs. Las Vegas has some upside, but the Bears have the better defense and a more compelling narrative on offense.

KC is pretty tough to beat at home, so betting against them in front of their own crowd is usually a bad idea. I definitely fear the Raves, but getting Kansas City at -120 at home is great value.

If you want to parlay these three picks, you can. Another option is to check out the best NFL parlays we piece together every week, should you be seeking a bit more upside.