Our best NFL parlay for Week 3 is three legs: Lions -6.5 against the Jets, Giants -3 against the Titans, and the over 40 in Seahawks at Commanders. At the median prices on offer, a $100 ticket returns about $714 if all three win.
Every leg is the call on our own game page for that game, quoted as it stands there and inside the range that page gives. All three kick off at 1:00 pm ET on Sunday, September 27.
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The Week 3 parlay
| Leg | Game | Price | Our game page says it is still a bet |
|---|---|---|---|
| Lions -6.5 | Jets at Lions | -115 | Up to -8.5; a pass at -9 or beyond |
| Giants -3 | Titans at Giants | +100 | Up to -7; a pass at -7.5 |
| Over 40 | Seahawks at Commanders | -110 | Up to 44.5; a pass at 45 or higher |
The lines are the median of 11 US sportsbooks, as of 00:10 UTC on September 24, 2026. Each price is the median among the books hanging that exact number: nine books had Detroit at -6.5, seven had New York at -3, and seven had the total at 40.
Three prices multiply into one. In decimal odds that is 1.87 times 2.00 times 1.91, or 7.14, so $100 returns $713.83, a profit of $613.83. The ticket needs all three to win, and at that price it has to cash 14.0% of the time to pay back what it costs.
Leg 1: Lions -6.5 against the Jets
Our Jets at Lions prediction opens: “Detroit -6.5 is short of where last season’s rates put this game. The pick is Detroit -6.5.”
Its working puts the game at Detroit by about ten and a half, from 28.3 points scored and 24.3 allowed by the Lions last season against 17.6 and 29.6 for the Jets. That is a four-point edge on the market’s 6.5, and the page says a move to -9 or beyond would make it a pass.
Leg 2: Giants -3 against the Titans
Our Titans at Giants prediction opens: “Two teams that won seven games between them last season, and the better of them is laying three at home. Give me the Giants.”
New York went 4-13 last season and Tennessee 3-14, but the Giants were outscored by 58 points and the Titans by 194. The page makes this New York by ten, against a median line of three. Its worst price is -7, so the current -3 sits well inside it.
Leg 3: over 40 in Seahawks at Commanders
Our Seahawks at Commanders prediction opens: “Seattle -7 on the road is priced about where last season’s rates put it. The total is not, and the rates point to the over 40.”
Seattle scored 28.4 a game last season and Washington allowed 26.5, which average to 27.45 for Seattle. Washington scored 20.9 and Seattle allowed 17.2, which average to 19.05. Together that is 46.5 against a total of 40. The page’s cut-off is 44.5.
Why these three
They carry the widest edges any of our Week 3 pages states: seven points on the Giants, six and a half on the total, four on the Lions. Each one also has room before its own pass line, so a half-point move this week does not take a leg out of range.
None of the three pages carries injury data, and the Lions and Seahawks pages say so directly, so check the injury reports before betting. A push on Giants -3, if New York wins by exactly three, is settled by each book’s own parlay rules.
Every call on our Week 3 board
| Game | Kickoff (ET) | Our call | Line now | Limit stated on the page |
|---|---|---|---|---|
| Falcons at Packers | Thu 8:15 pm | No bet at Falcons +5.5 | Packers -5.5 | A bet again at +6.5 |
| Chargers at Bills | Sun 1:00 pm | Chargers +7.5 | Bills -7.5 | Still a bet at +7, not at +6.5 |
| Panthers at Browns | Sun 1:00 pm | Browns +2.5 | Browns +2.5 | A pass at +2 |
| Jets at Lions | Sun 1:00 pm | Lions -6.5 | Lions -6.5 | A pass at -9 or beyond |
| Texans at Colts | Sun 1:00 pm | Colts +2.5 | Colts +2.5 | None stated |
| Chiefs at Dolphins | Sun 1:00 pm | Dolphins +11.5 | Dolphins +11.5 | Worst price +9.5 |
| Titans at Giants | Sun 1:00 pm | Giants -3 | Giants -3 | Worst price -7 |
| Bengals at Steelers | Sun 1:00 pm | Steelers +3.5 | Steelers +3.5 | Still a bet at +3, a pass at +2.5 |
| Seahawks at Commanders | Sun 1:00 pm | Over 40 | 40 | A bet up to 44.5 |
| Patriots at Jaguars | Sun 1:00 pm | Patriots +3 | Jaguars -3 | Worst price +2 |
| Cardinals at 49ers | Sun 4:05 pm | Cardinals +8.5 | 49ers -8.5 | A pass at +7.5 |
| Vikings at Buccaneers | Sun 4:05 pm | Buccaneers +1.5 | Buccaneers +1.5 | Worst price +1.5 |
| Ravens at Cowboys | Sun 4:25 pm | Over 52.5 | 52.5 | None stated |
| Raiders at Saints | Sun 4:25 pm | Under 43.5 | 43.5 | Worst price under 42.5 |
| Rams at Broncos | Sun 8:20 pm | Broncos +2.5 | Broncos +2.5 | Worst price +1.5 |
| Eagles at Bears | Mon 8:15 pm | Bears +4.5 | Bears +4.5 | None stated |
Every line is the median of 11 books at 00:10 UTC on September 24. Any of the bets can stand in for a leg above, as long as its line is still inside the limit its own page gives. Falcons at Packers is a no bet at the current number, and the three calls without a stated limit are best left out of a parlay for that reason.
How an NFL parlay pays
A parlay pays the product of its legs’ decimal prices. A -110 leg is 1.91, a +100 leg is 2.00, and a -115 leg is 1.87. Two legs at -110 make about 3.64, so a $100 ticket returns about $364. Every leg you add raises the payout and lowers the chance that the whole ticket wins.
That is the trade. A single -110 bet needs to win 52.4% of the time to break even, and our three-leg ticket needs 14.0%. Adding a leg is only worth it when you rate that leg’s chance higher than its own price does.
More NFL betting
Every game page for the week is on the NFL predictions hub. The long view is in our AFC Championship odds, NFC Championship odds and Super Bowl odds.
Parlay payouts differ from book to book, so compare them in our sportsbook reviews. For paid NFL picks from other handicappers, see our best handicappers page.