Jacksonville Jaguars vs Los Angeles Rams Picks and Predictions October 19th 2025

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Los Angeles Rams vs Jacksonville Jaguars Match Preview

The Los Angeles Rams are back in London for the first time since 2019, but they may be without their biggest offensive weapon when they meet the Jacksonville Jaguars at Wembley Stadium on Sunday. Wide receiver Puka Nacua is doubtful after suffering an ankle injury in last week’s 17-3 win over Baltimore.

Los Angeles (4-2) sits in a three-way tie atop the NFC West and continues to build toward another postseason run under coach Sean McVay. Nacua leads the NFL in receptions and ranks second in receiving yards, but the Rams might take a cautious approach given their upcoming bye. McVay hinted that resting the star wideout could be best long-term, noting that returning “to performance” is as important as returning “to play.”

The Jaguars (4-2) have also been one of the AFC’s most balanced teams under first-year head coach Liam Coen, who spent multiple years on McVay’s staff in Los Angeles. Coen’s familiarity with McVay’s system adds intrigue to this London matchup, with both teams among the top ten in scoring defense entering Week 7.

For live updates on spreads, totals, and line movement, visit the NFL scores and odds page.

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Movement and Odds

The Rams opened as 3-point favorites, with a total of 44.5 points. Early betting action has leaned slightly toward Los Angeles, though Jacksonville’s overseas experience and recent defensive metrics have drawn some sharp money on the underdog side.

Track expert projections and player prop trends through the NFL picks section.

NFL
2025-10-19 06:30
Open
LOS ANGELES RAMS
5 PICKS
JACKSONVILLE JAGUARS
NFL
2025-10-19 10:00
Open
NEW ORLEANS SAINTS
2 PICKS
CHICAGO BEARS
NFL
2025-10-19 10:00
Open
NEW ENGLAND PATRIOTS
5 PICKS
TENNESSEE TITANS
NFL
2025-10-19 13:05
Open
INDIANAPOLIS COLTS
3 PICKS
LOS ANGELES CHARGERS
NFL
2025-10-19 13:05
Open
NEW YORK GIANTS
2 PICKS
DENVER BRONCOS
NFL
2025-10-19 17:20
Open
ATLANTA FALCONS
3 PICKS
SAN FRANCISCO 49ERS

Matchup Breakdown

Matthew Stafford and the Rams’ offense continue to rely on efficiency and timing, ranking near the top of the league in passing production. Stafford has 1,684 passing yards and 12 touchdowns through six games, with veterans like Kyren Williams and Davante Adams helping maintain stability even when Nacua is sidelined. The Rams’ defensive front, led by Byron Young, remains a force — tied for fourth in the NFL with 19 sacks.

Defensively, Los Angeles is third in scoring defense and eighth in total yards allowed, giving up just 18.3 points per game. Their ability to pressure quarterbacks will test Jacksonville’s offensive line, which surrendered seven sacks last week in a 20-12 loss to Seattle.

For Jacksonville, Trevor Lawrence remains the steady hand under center, throwing for 258 yards and two scores last week. The offense features a strong balance with Travis Etienne Jr. on the ground and rookie Brian Thomas Jr. emerging as a dynamic receiver. Lawrence’s poise and Etienne’s versatility are crucial against a Rams defense that thrives on forcing turnovers.

Jacksonville’s defensive unit ranks among the top half of the league, but losing linebacker Devin Lloyd — who leads the NFL with four interceptions — is a major setback. The Jaguars’ front seven must find ways to disrupt Stafford without leaving coverage gaps for the Rams’ play-action attack.

For detailed team trends and matchup insights, visit the expert NFL betting guide.

Key Storylines

Both teams enter London with 4-2 records and playoff implications in play. For the Rams, this is about maintaining pace in a loaded NFC West while managing key injuries. For Jacksonville, it’s about proving they can rebound quickly after last week’s home loss.

Liam Coen’s reunion with Sean McVay adds a strategic subplot. Coen’s familiarity with McVay’s play-calling tendencies could help Jacksonville prepare defensively, though few coaches have succeeded in containing Los Angeles’ rhythm passing game for four quarters.

Wembley Stadium has been a second home for the Jaguars, who are 7-6 all-time in UK appearances. Meanwhile, the Rams are 2-2 in international contests, including a 24-10 win in their last London visit.

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Prediction

The Rams’ defensive pressure and Stafford’s consistency should prove too much for a Jaguars offense missing key contributors. Jacksonville’s overseas comfort may keep it close early, but Los Angeles’ pass rush and balanced attack tilt the edge late.

Projected Score: Los Angeles Rams 27, Jacksonville Jaguars 20
Best Bet: Rams -3.0 (-105)
Secondary Lean: Over 44.5 (-115)

Find more international matchup coverage and expert NFL Week 7 analysis at ScoresAndStats NFL Picks.