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Los Angeles Chargers vs Denver Broncos September 21st 2025
The Denver Broncos will visit the Los Angeles Chargers in a Week 3 game of the 2025 NFL season. The game takes place at SoFi Stadium in Inglewood, California. It will be an afternoon game on Sunday, September 21, 2025, starting at 4:05 PM and broadcast on CBS.
The Broncos enter this game with a 1-1 record, having won at home but lost on the road. The Chargers, under head coach Jim Harbaugh, have a perfect 2-0 record. Weather conditions are expected to be mild with scattered clouds, but the dome setting at SoFi Stadium means wind will not affect play.
Broncos vs Chargers Key Information
- Sport: Football
- Teams: Denver Broncos vs. Los Angeles Chargers
- Venue: SoFi Stadium in Inglewood, CA
- Date: Sunday, September 21, 2025
- Betting Odds: Broncos Moneyline +130, Chargers Moneyline -155, Broncos Spread +2.5 (-103), Chargers Spread -2.5 (-118), Total Over 45.5 (-112), Total Under 45.5 (-107)
The Denver Broncos travel west to face the Los Angeles Chargers in an AFC West showdown with early division implications. Denver’s defense remains its calling card, while the Chargers enter as one of the most balanced teams in the NFL. For a complete list of betting breakdowns, visit the NFL picks page.
Game Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Denver Broncos | +2.5 (-110) | +125 | O 45.5 (-110) |
| Los Angeles Chargers | -2.5 (-110) | -145 | U 45.5 (-110) |
(odds subject to change – find the latest updates on the NFL odds board)
The Broncos Can Win If…
Denver is coming off a heartbreaking 29-28 loss to Indianapolis but continues to show promise behind quarterback Bo Nix. He threw for 206 yards and three touchdowns, while running back J.K. Dobbins added 76 rushing yards and a score.
The Broncos’ strength remains their defense, which led the league in sacks last year with 63 and ranked third in opponent scoring. If they can pressure Justin Herbert and keep the game low-scoring, Denver has a legitimate path to an upset.
With playmakers like Courtland Sutton and Troy Franklin stretching the field, Denver’s passing game has enough punch to challenge LA’s secondary. For deeper team insights, explore the NFL teams hub.
The Chargers Can Win If…
Los Angeles is rolling after a 20-9 win over the Raiders. Justin Herbert, currently leading the league in passing yards and touchdowns, finished with 242 passing yards and two scores. His chemistry with Quentin Johnston and Keenan Allen is clicking.
The Chargers’ defense is elite, ranking first in opponent scoring last season and top-five in sacks and interceptions. That combination makes them one of the most complete teams in the AFC.
If Herbert maintains efficiency and the defense forces Bo Nix into mistakes, LA should protect home field and move to 3-0. For more betting strategy on teams like the Chargers, check the NFL betting guide.
Key Betting Trends
| Trend | Stat |
|---|---|
| Broncos ATS | 4-2 in last 6 games vs AFC West |
| Chargers ATS | 6-3 in last 9 as favorites |
| Broncos O/U | Over in 4 straight road games |
| Chargers O/U | Under in 6 of last 8 vs AFC opponents |
Stay updated on futures and playoff projections by visiting the Super Bowl odds blog.
The Lean
The Chargers are 2.5-point favorites, and my model projects a 24-21 LA win. Denver’s defense will keep things tight, but Herbert’s consistency gives Los Angeles the edge. The recommended pick is Chargers -2.5.
The total is set at 45.5, with the model projecting 45 points. Given both defenses’ ability to create turnovers and limit explosive plays, the under is the sharper play.
For full matchup previews around the league, head to the NFL scores and stats section.
