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Game Preview: Buffalo Bills @ Pittsburgh Steelers
The Buffalo Bills head to Acrisure Stadium to take on the Pittsburgh Steelers in a critical AFC battle in Week 13. With playoff positioning on the line, both teams will be looking to bounce back from losses.
Buffalo enters at 7-4 following a Thursday night defeat to Houston, while Pittsburgh sits at 6-5 after falling to Chicago. The weather forecast calls for cold rain and wind, which could test both quarterbacks in a physical matchup.
This game has postseason implications, and bettors seeking smart angles should understand how the spread works in betting, especially in late-season divisional races.
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Odds and Key Information
| Category | Details |
|---|---|
| Matchup | Buffalo Bills @ Pittsburgh Steelers |
| Venue | Acrisure Stadium, Pittsburgh, PA |
| Date | Sunday, Nov. 30, 2025 |
| Time | 4:25 PM ET |
| Broadcast | CBS |
| Bills ML | -199 |
| Steelers ML | +166 |
| Spread | Bills -3.5 (-111) |
| Total | 47.5 (O/U) |
Full lines available on the NFL odds page
Buffalo Bills Outlook
The Bills are leaning on MVP quarterback Josh Allen to stay in the AFC playoff race. Allen has thrown for 2,709 yards and 18 touchdowns but has taken a pounding behind a struggling offensive line. After eight sacks allowed last week, Buffalo must adjust protections quickly.
Running back James Cook continues to shine, ranking second in rushing yards across the league. The addition of veteran wide receiver Brandin Cooks brings experience to a receiving corps already led by Khalil Shakir.
Buffalo’s defense is a top-5 unit in opponent interceptions and red zone stops. This performance aligns with key metrics explained in the NFL betting strategy guide—showing why the Bills remain betting favorites despite inconsistency.
Injury concerns include Dalton Kincaid (hamstring), Terrel Bernard (elbow), and multiple offensive linemen. Understanding how betting odds adjust with injuries is critical before placing wagers.
Pittsburgh Steelers Outlook
The Steelers have been up and down this season but remain a tough out at home. Quarterback Aaron Rodgers is questionable with a wrist injury, which could mean another start for Mason Rudolph. Either way, Pittsburgh’s offense will rely heavily on the ground game.
Jaylen Warren leads the backfield with over 600 rushing yards, while DK Metcalf anchors the receiving corps with five touchdowns. The Steelers’ offense may not be elite in total yards, but they’ve been efficient in the red zone—an edge outlined in the alternate total points betting guide.
Pittsburgh’s defense still boasts T.J. Watt and Alex Highsmith, and they rank top 10 in pressures and sacks. However, injuries are mounting, including absences or limitations for Rodgers, Broderick Jones, and Joey Porter Jr.
In a game where turnovers could shift the outcome, Pittsburgh’s unit must force short fields to pull off the upset. Bettors considering the underdog should brush up on hedge betting strategies to manage exposure in high-variance games.
Key Matchup
Josh Allen vs Steelers Pass Rush
Buffalo’s offensive line was overwhelmed last week, and the Steelers are one of the best in creating pressure. If Allen cannot get into rhythm early, Pittsburgh could control time of possession with their ground game. Look for key third-down plays to swing momentum.
This matchup also highlights the importance of understanding what is a unit in betting, especially when evaluating potential live bets and second-half wagers.
Betting Trends
Buffalo is 7-1 straight up in its last 8 home games
Buffalo is 3-0 ATS as underdogs in their last three games
Pittsburgh is 4-1 SU in their last five home games
Pittsburgh is 4-1 ATS in their last five at home
Over has hit in 8 of Buffalo’s last 15 games
Pittsburgh is 4-1 SU following a loss
Learn how to read trends like a pro with the NFL betting basics guide
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Real Trends, Real Edges, Real Wins
Predictions
Buffalo’s edge at quarterback and explosive potential on offense give them a clear upper hand, even if Rodgers plays for Pittsburgh. With cold weather and ball control dictating the flow, expect a physical game with efficient scoring.
Projected Score: Bills 28, Steelers 21
Spread Pick: Bills -3.5
Total Lean: Over 47.5
If you’re wagering on totals or props, consider the insights from the Super Bowl prop betting breakdown to guide your markets.
Why You Need Expert Picks
Every edge counts during the playoff push. The Handicappers Leaderboard showcases winning experts across NFL and other sports, with transparent results and streak tracking.
Whether you’re exploring futures betting or curious about parlay bets, ScoresAndStats provides a complete knowledge base for your betting journey.
