Tampa Bay Buccaneers vs Philadelphia Eagles Picks and Predictions September 28th 2025

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The Philadelphia Eagles will take on the Tampa Bay Buccaneers in Week 4 of the 2025 NFL season. The game will be held at Raymond James Stadium in Tampa Bay, Florida. It is set to kick off at 1:00 PM on Sunday, September 28, and will be broadcasted on FOX.

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Both teams enter the game with a perfect 3-0 record. The Eagles, led by head coach Nick Sirianni, are coming off a strong start to the season. The Buccaneers, under the guidance of head coach Todd Bowles, also have a strong record. The weather forecast predicts a warm day with clear skies, making it a great day for football.

Eagles vs Buccaneers Key Information

  • Sport: Football
  • Teams: Philadelphia Eagles vs. Tampa Bay Buccaneers
  • Venue: Raymond James Stadium in Tampa Bay, FL USA
  • Date: Sunday, September 28, 2025
  • Betting Odds: Eagles Moneyline -189, Buccaneers Moneyline +158, Eagles Spread -3.5 (-108), Buccaneers Spread +3.5 (-111), Total Over 43.5 (-112), Total Under 43.5 (-109)

The Eagles Can Win If…

The Philadelphia Eagles are coming off a strong performance against the Los Angeles Rams, winning 33-26. Jalen Hurts led the way with 226 yards and three touchdowns. A.J. Brown was a key target, catching six passes for 109 yards and a touchdown.

The Eagles have shown they can win with both their offense and defense. They rank 2nd in rushing yards from last season, which makes them a threat on the ground. Their defense also stands out, ranking 2nd in opponent scores and 1st in opponent offensive yards, making it tough for other teams to score.

Key players like Saquon Barkley and Dallas Goedert are expected to perform well. Barkley is projected to rush for 96.7 yards, while Goedert could add 41.4 receiving yards. With their balanced attack and solid defense, the Eagles have a good chance to win this game.

The Buccaneers Can Win If…

The Tampa Bay Buccaneers are coming off a close win against the New York Jets, with a final score of 29-27. Baker Mayfield led the charge with 233 passing yards and a touchdown. Emeka Egbuka was a key target, catching six passes for 85 yards.

The Buccaneers have a strong offensive lineup, ranking 4th in rushing yards last season. They also rank 1st in third down percentage, showing their ability to keep drives alive. Baker Mayfield’s performance has been consistent, with no interceptions in the past three games.

On defense, Tampa Bay is solid, ranking 5th in sacks last season. Lavonte David and Antoine Winfield Jr. are key players, each recording a sack in the last game. With a strong offense and a capable defense, the Buccaneers have a good chance to win their upcoming game.

The Lean

The Eagles are favored by 3.5 points against the Buccaneers. Given the Eagles’ strong ATS record, especially on the road, they are a good pick to cover the spread. The Eagles have covered the spread in their last 7 away games, making them a reliable choice in this matchup.

The total for the game is set at 43.5. The Buccaneers have a strong tendency to hit the over, especially at home, where they have gone over in their last 3 games. With both teams having potent offenses, the over is a favorable pick for this game.

Eagles vs Buccaneers Preview

The Philadelphia Eagles (3-0) travel to face the Tampa Bay Buccaneers (3-0) in the NFL’s only matchup of unbeaten teams this week. Philadelphia has won 19 of its last 20 games but has dropped its last two against Tampa, including last year’s playoff loss.

Baker Mayfield has fueled the Bucs’ best start since 2005, with three last-minute wins capped by a game-winning drive against the Jets. Jalen Hurts answered with three second-half touchdown passes in a 33-26 comeback against the Rams, highlighted by a 61-yard blocked field goal return.

Injury Report

The Eagles placed edge rusher Nolan Smith, corner Jakorian Bennett, and wideout Darius Cooper on injured reserve. Left tackle Lane Johnson (stinger) was limited, while Zack Baun (knee), Jihaad Campbell (triceps), and Adoree’ Jackson (groin) sat out practice.

The Buccaneers will be without Mike Evans (hamstring) and tight end Ko Kieft (leg). Chris Godwin and Tristan Wirfs could return, but their status will be decided late in the week. Baker Mayfield (biceps) and Lavonte David (knee) were limited, and Logan Hall (groin) missed practice.

Betting Results and Trends

Philadelphia opened as a slight road favorite on the NFL odds page. The line shifted after news of Evans’ injury. The Eagles are 2-1 ATS and trending toward close games, while Tampa is 3-0 ATS with three wins by a combined six points. Totals have leaned Over in Bucs games, while the Eagles’ defense has kept scoring tighter.

What It Means Moving Forward

Philadelphia’s offensive line health is critical, especially with Lane Johnson banged up. Saquon Barkley needs a bounce-back game after averaging 3.3 yards per carry, but Tampa hasn’t allowed a 100-yard rusher in 11 straight contests. The Bucs look to prove their 3-0 start is sustainable without Evans, relying on Mayfield’s efficiency and defensive consistency.

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